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简体标题：透过组织之光学性质进行之葡萄糖非入侵性量测 NONINVASIVE MEASUREMENT OF GLUCOSE THROUGH THE OPTICAL PROPERTIES OF TISSUE

公开(公告)号：TWI324686B

公开(公告)日：2010-05-11

申请号：TW091101414

申请日：2002-01-28

申请人：塞西斯醫藥股份有限公司

发明人：提姆西L 羅西第 , 湯瑪士B 伯藍克 , 亞歷山大勒倫佐 , 蘇瑞須N 莎納迪歐 , 史帝芬L 孟佛雷

IPC分类号： G01N

CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/1495 , A61B2560/0223 , G01N21/31 , G01N21/33 , G01N21/359 , G01N2021/3595

摘要：供非侵入性量測血液中分析物(例如葡萄糖)之方法與設備，其係利用可反映組織光學特性之關鍵光譜特徵之近紅外光光譜，來增進測量之準確度與精確度。生理狀態，例如水在各組織區間間的分布會造成所測得之皮膚吸收光譜產生複雜變化並也使有效光徑長度產生變化，導致非侵入性葡萄糖測量產生誤差。組織光學特性的改變可經由辨別與生理變動具相關性之關鍵特徵找出。故不利於非侵入性葡萄糖量測之狀況可以被測出，並對生理狀態造成之非侵入性葡萄糖測量誤差加以補償。在他種具體實施例中，葡萄糖可經由組織因葡萄糖濃度變化造成之自然生理反應間接量測。本發明提供一種可進行上述測量之光譜設備。 Methods and apparatus for noninvasive determination of blood analytes, such as glucose, through NIR spectroscopy utilize optical properties of tissue as reflected in key spectroscopic features to improve measurement accuracy and precision. Physiological conditions such as changes in water distribution among tissue compartments lead to complex alterations in the measured absorbance spectrum of skin and reflect a modification in the effective pathlength of light, leading to a biased noninvasive glucose measurement. Changes in the optical properties of tissue are detected by identifying key features responsive to physiological variations. Conditions not conducive to noninvasive measurement of glucose are detected. Noninvasive glucose measurements that are biased by physiological changes in tissue are compensated. In an alternate embodiment, glucose is measured indirectly based on natural physiological response of tissue to glucose concentration. A spectroscopic device capable of such measurements is provided. 【創作特點】水在各組織區間的分布變化與其他生理特性的變化導致進行皮膚吸收光譜測量時的複雜變化與需對有效光徑進行修正。這些動態變化造成非葡萄糖侵入性測量的誤差並限制該項技術的應用。本發明所揭露的技術可提供一種方法與設備，其係利用與組織光學特性相關之關鍵的光學特徵，來增進以近紅外光光譜進行葡萄糖非侵入性測量時的準確度與正確性。更明確的說，本方法是經由辨認可反映生理變化情形的關鍵的光學特徵來偵測組織光學特性變化。第二，本方法亦提供來偵測不適合以非侵入性方法測量葡萄糖之狀況。第三、本發明亦提供一種裝置用於補償非侵入性葡萄糖測量因組織生理變化造成的誤差。第四、本方法揭露利用組織因葡萄糖濃度所產生之生理變化為基礎所發展之葡萄糖間接測量方法。最後會對進行該種方法所需之設備進行詳細描述。

简体摘要：供非侵入性量测血液中分析物(例如葡萄糖)之方法与设备，其系利用可反映组织光学特性之关键光谱特征之近红外光光谱，来增进测量之准确度与精确度。生理状态，例如水在各组织区间间的分布会造成所测得之皮肤吸收光谱产生复杂变化并也使有效光径长度产生变化，导致非侵入性葡萄糖测量产生误差。组织光学特性的改变可经由辨别与生理变动具相关性之关键特征找出。故不利于非侵入性葡萄糖量测之状况可以被测出，并对生理状态造成之非侵入性葡萄糖测量误差加以补偿。在他种具体实施例中，葡萄糖可经由组织因葡萄糖浓度变化造成之自然生理反应间接量测。本发明提供一种可进行上述测量之光谱设备。 Methods and apparatus for noninvasive determination of blood analytes, such as glucose, through NIR spectroscopy utilize optical properties of tissue as reflected in key spectroscopic features to improve measurement accuracy and precision. Physiological conditions such as changes in water distribution among tissue compartments lead to complex alterations in the measured absorbance spectrum of skin and reflect a modification in the effective pathlength of light, leading to a biased noninvasive glucose measurement. Changes in the optical properties of tissue are detected by identifying key features responsive to physiological variations. Conditions not conducive to noninvasive measurement of glucose are detected. Noninvasive glucose measurements that are biased by physiological changes in tissue are compensated. In an alternate embodiment, glucose is measured indirectly based on natural physiological response of tissue to glucose concentration. A spectroscopic device capable of such measurements is provided. 【创作特点】水在各组织区间的分布变化与其他生理特性的变化导致进行皮肤吸收光谱测量时的复杂变化与需对有效光径进行修正。这些动态变化造成非葡萄糖侵入性测量的误差并限制该项技术的应用。本发明所揭露的技术可提供一种方法与设备，其系利用与组织光学特性相关之关键的光学特征，来增进以近红外光光谱进行葡萄糖非侵入性测量时的准确度与正确性。更明确的说，本方法是经由辨认可反映生理变化情形的关键的光学特征来侦测组织光学特性变化。第二，本方法亦提供来侦测不适合以非侵入性方法测量葡萄糖之状况。第三、本发明亦提供一种设备用于补偿非侵入性葡萄糖测量因组织生理变化造成的误差。第四、本方法揭露利用组织因葡萄糖浓度所产生之生理变化为基础所发展之葡萄糖间接测量方法。最后会对进行该种方法所需之设备进行详细描述。

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