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    • 10. 发明公开
    • 수성계 약제 조성물
    • 水解药物组合物
    • KR1020000023563A
    • 2000-04-25
    • KR1019997000006
    • 1997-07-02
    • 아벤티스 파마슈티컬스 홀딩스 인크.
    • 김수일
    • A61K9/00
    • A61K9/0043A61K9/006A61K9/08A61K31/573A61K31/58A61K47/32A61K47/36A61K47/38B05B11/3018Y10S514/951Y10S514/975
    • PURPOSE: A hydro-pharmaceutical composition containing anti-inflammatory steroid, e.g., triamcinolon acetonide is provided, which can be sprayed into the nasal cavity. Also provided are a using method and a manufacturing process of the composition. CONSTITUTION: The composition comprises of: (A) solid particles to treat the physical condition by existing on the surface of the nasal cavity; (B) a suspension maintaining the particles to be dispersed evenly in the composition. The emulsion makes the composition to be: (i) a gel-type having relatively higher potential viscosity in not-shaken state; (ii) introduced easily into the nasal path by lowered viscosity after shaking; and (iii) resistant to eliminating from the surface of the mucous membrane by relatively higher viscosity.
    • 目的:提供含有抗炎类固醇(例如曲安奈德)的水药物组合物,其可以喷雾到鼻腔中。 还提供了组合物的使用方法和制造方法。 构成:组合物包括:(A)通过存在于鼻腔表面来治疗身体状况的固体颗粒; (B)将颗粒均匀地分散在组合物中的悬浮液。 该乳液使组合物为:(i)在非摇动状态下具有较高电位粘度的凝胶型; (ii)通过摇动后降低的粘度容易地引入鼻道; 和(iii)通过相对较高的粘度来抵抗从粘膜的表面上的消除。