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1. 发明授权

KR101534578B1 황이 함유된 유기화합물의 정량방법 有权
标题翻译：含硫有机化合物的定量方法
公开(公告)号：KR101534578B1
公开(公告)日：2015-07-09
申请号：KR1020130159867
申请日：2013-12-20
申请人： 한국표준과학연구원
发明人： 임용현 , 이현석 , 김숙현 , 이경석 , 정지선 , 김숙경
IPC分类号： C01B17/00 , C07B59/00
CPC分类号： G01N33/74 , G01N33/6815 , G01N33/6848 , G01N2333/61
摘要： 본발명은황이함유된유기화합물의정량방법에관한것이다. 황이함유된화합물은제한없이본 발명의정량방법으로정량하는것이가능하지만, 바람직하게는생체물질과같은거대분자또는흡습성이있거나수화물형태인경우와같이정량이어려운유기화합물을정량하는데보다효과적이다. 본발명의정량방법은생체물질중에서도펩티드또는단백질의고순도표준물질을매우효과적으로정량할수 있다. 펩티드또는단백질의아미노산중에서메티오닌또는시스테인에함유된황의동위원소비를측정하는것으로S,S 및S 중에서선택된어느하나의동위원소가농축된내부표준용액과, 대조물질로서황 원소표준용액을보정용표준용액으로사용하는것이특징이다. 시료를산분해하여무기물형태로황을분해한후S,S 및S 중에서선택된어느하나의동위원소/S 동위원소비를측정하여시료의농도를계산하는정량방법으로황을포함한불순물탐색및 정량을결합하여 SI 소급성을갖춘인증값(정량값)을획득할수 있다.

2. 发明公开

KR1020140080447A 황이 함유된 유기화합물의 정량방법 有权
标题翻译：含硫化合物有机化合物的量化方法
公开(公告)号：KR1020140080447A
公开(公告)日：2014-06-30
申请号：KR1020130159867
申请日：2013-12-20
申请人： 한국표준과학연구원
发明人： 임용현 , 이현석 , 김숙현 , 이경석 , 정지선 , 김숙경
IPC分类号： C01B17/00 , C07B59/00
CPC分类号： G01N33/74 , G01N33/6815 , G01N33/6848 , G01N2333/61
摘要： The present invention relates to a method to quantify an organic compound containing sulfur. A compound containing sulfur can be quantified by a means of the method of the present invention without restriction, but the method is preferably more effective in quantifying an organic compound that is difficult to be quantified like a giant molecule (biomaterial) or an absorptive/hydrate material. The method of the present invention can very effectively quantify a high purity standard material of peptides or proteins from among the biomaterial. An internal standard solution, whereby any one isotope selected from (^33)S, (^34)S, and (^36)S is concentrated, is used in order to measure the isotope ratio of sulfur that is contained in methionine or cysteine among the amino acid of peptides or proteins. As a control material, a sulfur element standard solution is used as a correcting standard solution. A sample is acid-decomposed so that sulfur is decomposed into an inorganic material form. Then, the isotope ratio of any one isotope selected from (^33)S, (^34)S, and (^36)S-(^32)S is measured. By the means of the method by which the concentration of a sample is calculated, the investigation and quantification of the impurities including sulfur are performed together, so that a certification value (quantification value) which satisfies SI traceability can be obtained.
摘要翻译：本发明涉及量化含硫有机化合物的方法。含硫化合物可以通过本发明方法进行定量，但不限于此，但是该方法优选在量化难以定量的有机化合物（如巨型分子（生物材料）或吸收/水合物）时更有效材料。本发明的方法可以从生物材料中非常有效地量化肽或蛋白质的高纯度标准物质。使用内标溶液，其中使用选自（^ 33）S，（^ 34）S和（→36）S的任何一种同位素进行浓缩，以测量甲硫氨酸或半胱氨酸中所含的硫的同位素比在肽或蛋白质的氨基酸之间。作为对照材料，使用硫元素标准溶液作为校正标准溶液。样品被酸分解，使得硫分解成无机材料形式。然后，测量从（^ 33）S，（^ 34）S和（^ 36）S - （^ 32）S中选择的任何一种同位素的同位素比。通过计算样品浓度的方法，一起进行包括硫的杂质的研究和定量，从而可以获得满足SI追溯性的认证值（量化值）。

3. 发明公开

KR1020170097212A 체중-증량 화합물의 장기 사용을 위한 조성물 및 방법 审中-实审
标题翻译：长期使用增重化合物的组合物和方法
公开(公告)号：KR1020170097212A
公开(公告)日：2017-08-25
申请号：KR1020177021599
申请日：2016-01-27
申请人： 아라타나 세라퓨틱스, 인크.
发明人： 로데스린다 , 레이차드마리-폴 , 졸러스빌 , 하이넨에른스트
IPC分类号： A61K38/05 , G01N33/74 , A23K50/40 , A23K20/184 , A23K20/132 , A23K20/137
CPC分类号： A61K38/05 , A23K20/111 , A23K20/132 , A23K20/137 , A23K20/184 , A23K50/10 , A23K50/20 , A23K50/30 , A23K50/40 , G01N33/74 , G01N33/743 , G01N2333/61 , G01N2333/65 , G01N2800/52 , Y10S426/805
摘要： 본출원은하나이상의반려동물또는가축에서의체중감소치료방법을제공한다. 이방법은치료적유효량의카프로모렐린-함유조성물을이를필요로하는반려동물또는가축에게최소한 30일의기간동안투여하는것을포함할수 있다. 선택적으로, 반려동물또는가축을위해하나이상의착향제또는향-차단제가카프로모렐린-함유조성물에추가되어상기조성물의향을개선또는차단할수 있다.
摘要翻译：本申请提供了治疗一种或多种伴侣动物或家畜的体重减轻的方法。该方法可以包括将治疗有效量的含有卡莫地林的组合物给予需要其的伴侣动物或动物持续至少30天的时间。或者，可将一种或多种调味剂或芳香剂阻断剂加入到用于伴侣动物或家畜的含有色氨酸的组合物中以改善或阻止组合物的倾向。

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