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    • 2. 发明授权
    • 세포 부착, 확산 및 탈착 활성을 나타내는 펩타이드 및그의 유도체
    • 세포부착,확산및탈착활성을나타내,펩타이드및그의유도체
    • KR100378949B1
    • 2003-04-08
    • KR1020000025665
    • 2000-05-13
    • (주)리젠바이오텍
    • 김인산김정은
    • C07K7/00
    • A61K38/08C07K7/06C07K14/4718C07K14/78
    • The present invention relates to peptides and derivatives thereof showing cell attachment, spreading and detachment activity. Particularly, the present invention relates to the peptide NKDIL and EPDIM and derivatives thereof which promote the cell attachment activity through interaction with a alpha 3beta 1 integrin as a functional cell receptor and include aspartic acid and isoleucine essential for cell attachment and detachment activity. The peptides and derivatives thereof in the present invention can be used for developing a study of cell attachment activity mediated through various extracellular matrix protein containing beta ig-h3, wound healing, tissue regeneration and metastasis inhibition.
    • 本发明涉及显示细胞附着,扩散和分离活性的肽及其衍生物。 特别地,本发明涉及通过与作为功能细胞受体的αβ1整联蛋白相互作用来促进细胞附着活性的肽NKDIL和EPDIM及其衍生物,并且包括对于细胞附着和分离活性必需的天冬氨酸和异亮氨酸。 本发明中的肽和其衍生物可用于开发通过各种含有βig-h3的细胞外基质蛋白介导的细胞附着活性,伤口愈合,组织再生和转移抑制的研究。