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    • 8. 发明公开
    • 공압식 바이오리액터
    • 气动生物反应器
    • KR1020080071994A
    • 2008-08-05
    • KR1020087011926
    • 2006-10-24
    • 피비에스 바이오텍 인코퍼레이티드
    • 제이쿠스,제이.,그레고리
    • C12M1/06B01F13/00
    • B01F3/04113B01F3/04602B01F7/00483B01F11/0082B01F15/005B01F15/00525C12M23/56C12M27/02C12M27/06
    • A pneumatic bioreactor includes a vessel containing a fluid to be mixed and at least one mixing device driven by gas pressure. A first embodiment includes a floating impeller that rises and falls In the fluid as gas bubbles carry it upward to the surface where the gas is then vented, permitting the impeller to sink in the fluid. The floating impeller may be tethered to a second impeller with a flexible member and pulley. The mixing speed is controlled with electromagnets in the vessel acting upon magnetic material in the impeller or its guides. In another embodiment, floating pistons mix the fluid, pushing it through a mixing plate with one or more apertures. In a third embodiment, the mixing device is a rotating drum vvith bubble-catching blades and rotating mixing plates with apertures. The top of the vessel for these mixers may include a closed top and sterile filters.
    • 气动生物反应器包括容纳待混合的流体的容器和由气体压力驱动的至少一个混合装置。 第一实施例包括浮动叶轮,其随着气泡将其向上运送到气体然后被排出的表面而在流体中,允许叶轮沉入流体中。 浮动叶轮可以用柔性构件和滑轮系在第二叶轮上。 混合速度由容器中的电磁体控制,作用在叶轮或其引导件中的磁性材料上。 在另一个实施例中,浮动活塞将流体混合,将其推入具有一个或多个孔的混合板。 在第三实施例中,混合装置是带有吸气片的旋转鼓和具有孔的旋转混合板。 用于这些混合器的容器的顶部可以包括封闭的顶部和无菌过滤器。