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1. 发明公开

KR1020130064162A 암의 증식, 재발 또는 전이 억제용 의약 조성물 无效
标题翻译：用于抑制癌症生长，复发或转移的药物组合物
公开(公告)号：KR1020130064162A
公开(公告)日：2013-06-18
申请号：KR1020110130483
申请日：2011-12-07
申请人： 한올바이오파마주식회사
发明人： 문애리 , 고민수 , 민창희 , 이순임
IPC分类号： A61K31/53
CPC分类号： A61K31/53
摘要： PURPOSE: A pharmaceutical composition for suppressing recurrence, proliferation, or metastasis of cancer is provided to effectively suppress proliferation, recurrence, or metastasis of cancer by suppressing cancer cell invasion. CONSTITUTION: A pharmaceutical composition for suppressing recurrence, proliferation, or metastasis of cancer contains a compound of chemical formula 1 or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier. The cancer is selected from the group consisting of breast cancer, uterine cancer, stomach cancer, brain cancer, rectal cancer, colon cancer, lung cancer, skin cancer, blood cancer, and liver cancer. The composition is simultaneously or sequentially administered with an anticancer agent.
摘要翻译：目的：提供抑制癌症复发，增殖或转移的药物组合物，以通过抑制癌细胞侵袭来有效抑制癌症的增殖，复发或转移。构成：用于抑制癌症复发，增殖或转移的药物组合物含有化学式1的化合物或其药学上可接受的盐; 和药学上可接受的载体。癌症选自乳腺癌，子宫癌，胃癌，脑癌，直肠癌，结肠癌，肺癌，皮肤癌，血癌和肝癌。该组合物同时或依次施用抗癌剂。

2. 发明公开

KR1020130055391A 메트포르민의 가바 또는 가바 유도체 염, 이의 제조방법 및 이를 유효성분으로 함유하는 약제학적 조성물 无效
标题翻译： METFORMIN-GABA盐及其衍生物，其制备方法和包含其的药物组合物
公开(公告)号：KR1020130055391A
公开(公告)日：2013-05-28
申请号：KR1020110121111
申请日：2011-11-18
申请人： 한올바이오파마주식회사
发明人： 문애리 , 고민수 , 민창희 , 이순임
IPC分类号： C07C279/26 , C07C229/08 , A61K31/155 , A61P35/00
摘要： PURPOSE: A metformin-gaba salt and the derivatives thereof are provided to have excellent treating effect for metabolic disease and diabetes and to suppress growth of cancer cells by having excellent AMPK activation effect. CONSTITUTION: A metformin-gaba salt and the derivatives thereof are represented by chemical formula 1. A manufacturing method thereof comprises a step of conduct a reaction of metformin hydrochloride represented by chemical formula 2, water, organic solvent, or a mixture solvent under the presence of a base, to manufacture a metformin glass base represented by chemical formula 3; and a step of conducting a reaction of the manufactured metformin glass base and gaba or a derivative thereof represented by chemical formula 4 or chemical formula 5, under the presence of water, organic solvent, or a mixture solvent thereof.
摘要翻译：目的：提供二甲双胍加巴盐及其衍生物以对代谢疾病和糖尿病具有优异的治疗效果，并通过具有优异的AMPK活化作用抑制癌细胞的生长。构成：二甲双胍盐酸盐及其衍生物由化学式1表示。其制造方法包括在存在下进行由化学式2表示的二甲双胍盐酸盐，水，有机溶剂或混合溶剂的反应的工序的碱，制造由化学式3表示的二甲双胍玻璃碱; 以及在水，有机溶剂或其混合溶剂的存在下，通过化学式4或化学式5表示的制造的二甲双胍玻璃基和gaba或其衍生物进行反应的步骤。

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