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    • 6. 发明公开
    • 단백질 수송 도메인과 공유결합된 치료용 단백질의 융합 단백질 및 이미프라민을 포함하는 뇌질환의 예방 및 치료용 조성물
    • 包含融合蛋白和IMIPRAMINE的脑病组合物
    • KR1020120119562A
    • 2012-10-31
    • KR1020110037574
    • 2011-04-22
    • 한림대학교 산학협력단
    • 최수영김대원박진서음원식황현숙김덕수임순성조성우
    • A61K47/42A61K9/38C07K19/00C12N9/02
    • A61K47/64A23L33/17A23V2200/322A61K47/22
    • PURPOSE: A composition for preventing and treating brain disorder including imipramine and fused protein which is covalently bonded with protein transport domains and a method for increasing the introduction of the fused protein are provided to reduce cytotoxin induced by hydrogen peroxide. CONSTITUTION: A method for increasing the introduction of the fused protein is processed by adding imipramine and fused protein which is covalently bonded with protein transport domains. The imipramine is primarily processed in the nerve cells or brain cells than the fusion protein. The protein transport domain is Tat, PEP-1, oligolysine, oligo arginine or oligo (the lysine, and the arginine). The therapeutic protein is active oxygen species excision enzyme. The therapeutic protein is catalase, superoxide dismutase or glutathione peroxidase. A composition for preventing and treating neural diseases or brain disorder includes the fused protein and imipramine of the enzyme having the removing activity of active oxygen species. The enzyme having the removing activity of active oxygen species is catalase, superoxide dismutase or glutathione peroxidase.
    • 目的:提供用于预防和治疗脑疾病的组合物,包括与蛋白质转运结构域共价结合的丙咪嗪和融合蛋白,以及增加引入融合蛋白的方法,以减少由过氧化氢诱导的细胞毒素。 构成:通过加入与蛋白质转运结构域共价结合的丙咪嗪和融合蛋白来加工融合蛋白的引入的方法。 丙米嗪主要在神经细胞或脑细胞中处理,而不是融合蛋白。 蛋白质转运结构域是Tat,PEP-1,寡聚赖氨酸,寡聚精氨酸或寡聚(赖氨酸和精氨酸)。 治疗性蛋白质是活性氧离子切除酶。 治疗性蛋白质是过氧化氢酶,超氧化物歧化酶或谷胱甘肽过氧化物酶。 用于预防和治疗神经疾病或脑疾病的组合物包括具有活性氧物质去除活性的酶的融合蛋白和丙米嗪。 具有活性氧脱除活性的酶是过氧化氢酶,超氧化物歧化酶或谷胱甘肽过氧化物酶。
    • 8. 发明公开
    • 장구채 뿌리 추출물을 포함하는 항암제 조성물
    • 用于包含梅毒粉末提取物的反刍动物药物的组合物
    • KR1020120000246A
    • 2012-01-02
    • KR1020100060503
    • 2010-06-25
    • 한림대학교 산학협력단
    • 허성오아타우르라만양해걸임순성김진규김남호
    • A61K36/36A61P35/00
    • PURPOSE: An anti-cancer composition containing Caryophyllaceae plant extract and a food composition containing the same are provided to induce rat-2 fibroblast and B103 apoptosis. CONSTITUTION: An anti-cancer composition contains Melandrium firmum extract as an active ingredient, extracted using water and alcohol of 1-5 carbon atoms at 50-100°C for 30 minutes to 12 hours. The extract is isolated from Melandrium firmum root using 10-95%(v/v) methanol. Melandrium firmum includes Melandrium Apricum, Melandrium Capitarum, or Melandrium Seoulensis. A health food contains the anti-cancer composition and supplementary food and further contains a proper carrier, excipient, and diluent.
    • 目的:提供含有Caryophyllaceae植物提取物和含有它们的食品组合物的抗癌组合物,以诱导大鼠-2成纤维细胞和B103细胞凋亡。 构成:抗癌组合物含有Melonrium坚果提取物作为活性成分,使用1-5个碳原子的水和醇在50-100℃下萃取30分钟至12小时。 使用10-95%(v / v)甲醇从Melandrium坚果根分离提取物。 枸杞子包括枸杞,Melonrium Capitarum或Melonrium Seoulensis。 保健食品含有抗癌成分和补充食品,并含有适当的载体,赋形剂和稀释剂。