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    • 9. 发明公开
    • 독활 및 만형자의 혼합 생약 추출물을 유효성분으로함유하는 관절염의 예방 및 치료용 조성물
    • 包含ARALIA CORDATA THUNB和VITEX ROTUNDIFOLIA L.混合提取物的组合物用于预防和治疗ARTHRITIS
    • KR1020080055205A
    • 2008-06-19
    • KR1020060128211
    • 2006-12-14
    • 경희대학교 산학협력단
    • 박동석유명철최도영이재동백용현허정은조용백한창균이해인정기원
    • A61K36/25A61K36/85A61P19/02
    • A composition comprising the mixed extracts of Aralia cordata THUNB and Vitex rotundifolia L. fil is provided to suppress edema and pain, inhibit proteoglycan in articular cartilage cell and activity of MMP-1(matrix metalloproteinase-1) and MMP-3, and induce no cytotoxicity and morphological change, so that the composition is useful for preventing and treating arthritis. A pharmaceutical or health food composition for preventing and treating arthritis comprises 0.1-50 wt.% of the mixed extracts of Aralia cordata THUNB and Vitex rotundifolia L. fil which are prepared by extracting them with water, C1-C4 lower alcohol including methanol or ethanol, or a mixed solvent thereof, wherein the arthritis is degenerative arthritis, rheumatoid arthritis or Lupus arthritis; and the daily dosage of the mixed extracts is 0.01mg/kg-10g/kg, preferably 1 mg/kg-1g/kg.
    • 提供包含Aralia cordata THUNB和Vitex rotundifolia L. fil的混合提取物的组合物,以抑制水肿和疼痛,抑制关节软骨细胞中的蛋白聚糖和MMP-1(基质金属蛋白酶-1)和MMP-3的活性,并诱导无 细胞毒性和形态变化,使得该组合物可用于预防和治疗关节炎。 用于预防和治疗关节炎的药物或保健食品组合物包括通过用水,C1-C4低级醇(包括甲醇或乙醇)提取它们制备的Aralia cordata THUNB和Vitex rotundifolia L. fil的混合提取物的0.1-50重量% 或其混合溶剂,其中所述关节炎是退行性关节炎,类风湿性关节炎或狼疮性关节炎; 混合提取物的日剂量为0.01mg / kg-10g / kg,优选为1mg / kg-1g / kg。