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    • 9. 发明公开
    • 방사선 피폭 측정용 바이오마커
    • 用于测量辐射照射的生物标志物
    • KR1020120056614A
    • 2012-06-04
    • KR1020100118237
    • 2010-11-25
    • 한국원자력의학원
    • 배상우최규진김광석이재연
    • C12N15/12C12Q1/68G01N33/68A61K31/7088
    • C12Q1/68C12N15/1135C12Q2600/158G01N33/6884G01N33/6893
    • PURPOSE: A biomarker for measuring radiation exposure found from human lung cancer cell line A549 is provided to develop drug which enhances radiation sensitivity. CONSTITUTION: A biomarker for measuring radiation exposure contains FBXL6(GenBank accession ID: NM_024555), PPP3CA(GenBank accession ID: BC025714), MOCS1(GenBank accession ID: NM_005942), ELAVL4(GenBank accession ID: AY033995), TMPRSS7(GenBank accession ID: AK131211), ID1(GenBank accession ID: NM_181353), ZNF239(GenBank accession ID: NM_005674), CDCA7(GenBank accession ID: BC027966), or DEAF1(GenBank accession ID: NM_021008) gene or expression protein thereof. A composition for enhancing radiation sensitivity contains the genes or inhibitor of the expression protein. The inhibitor is an antisense nucleic acid or siRNA.
    • 目的:提供用于测量人肺癌细胞系A549发现的辐射暴露的生物标志物,以开发增强辐射敏感性的药物。 构成:用于测量辐射暴露的生物标志物包含FBXL6(GenBank登录号:NM_024555),PPP3CA(GenBank登录号:BC025714),MOCS1(GenBank登录号:NM_005942),ELAVL4(GenBank登录号:AY033995),TMPRSS7(GenBank登录号 :GenBank登录号:NM_181353),ZNF239(GenBank登录号:NM_005674),CDCA7(GenBank登录号:BC027966)或DEAF1(GenBank登录号:NM_021008)基因或其表达蛋白。 用于增强辐射敏感性的组合物包含表达蛋白质的基因或抑制剂。 抑制剂是反义核酸或siRNA。