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    • 1. 发明公开
    • 삼산화비소를 포함하는 혈관신생억제제
    • 含有三氧化二砷的血管生成抑制剂
    • KR1020030075017A
    • 2003-09-22
    • KR1020020014092
    • 2002-03-15
    • 한국원자력연구원
    • 이창훈홍석일박인철이수재유두현박명진이형찬우상혁박영란김은희이재영서강문
    • A61K33/36
    • PURPOSE: An angiogenesis inhibitor containing arsenic trioxide having an inhibiting effect on proliferation, movement, immersion and vasculogenesis of endothelial cells in vitro is provided. The angiogenesis inhibitor is widely used for treatment of diseases that give rise to angiogenesis. CONSTITUTION: An angiogenesis inhibitor contains arsenic trioxide having an anti-angiogenic activity as an effective ingredient. Therefore, it can be used in treatment of diseases that give rise to angiogenesis, such as diabetics, a solid tumor, arthritis, psoriasis, pyogenic granuloma, renovascular glaucoma, etc. The arsenic trioxide is administered at a dosage of about 5 to 50mg/kg, prior to or during radiation therapy.
    • 目的:提供一种含有三氧化二砷的血管生成抑制剂,其对体外内皮细胞的增殖,运动,浸润和血管生成具有抑制作用。 血管生成抑制剂广泛用于治疗引起血管生成的疾病。 构成:血管生成抑制剂含有具有抗血管生成活性的三氧化二砷作为有效成分。 因此,可以用于治疗引起血管生成的疾病,例如糖尿病,实体瘤,关节炎,牛皮癣,化脓性肉芽肿,肾血管性青光眼等。三氧化二砷的剂量为约5〜50mg / kg,放射治疗之前或期间。