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    • 10. 发明公开
    • 말매미로부터 분리한 신규 항생활성 펩타이드
    • 具有抗菌活性的胶原蛋白分离自CRYPTOTYMPANA DUBIA
    • KR1020010077609A
    • 2001-08-20
    • KR1020000005508
    • 2000-02-03
    • 한국생명공학연구원
    • 박호용박두상신상운
    • C07K7/00
    • C07K14/43563A61K38/1767
    • PURPOSE: A peptide having antimicrobial activity isolated from Cryptotympana dubia is provided, which has improved antimicrobial activity and higher stability. CONSTITUTION: The peptide having antimicrobial activity and isolated from Cryptotympana dubia is represented by SEQ ID NO: 1 and has 2703 kDa of molecular weight. The peptide is synthesized with L-amino acids or D-amino acids and has antimicrobial activity against gram negative bacteria containing E. coli, gram positive bacteria containing Staphylococcus aureus, and fungi containing Candida albicans. The amino acid sequence of SEQ ID NO: 1 is optionally and partially modified or deleted to improve its antimicrobial activity.
    • 目的:提供一种具有抗氧化活性的分离自Cryptotympana dubia的肽,其具有改善的抗微生物活性和更高的稳定性。 构成:具有抗菌活性并从密码子分蘖中分离的肽由SEQ ID NO:1表示,分子量为2703kDa。 肽与L-氨基酸或D-氨基酸合成,并且对含有大肠杆菌的革兰氏阴性细菌,含有金黄色葡萄球菌的革兰氏阳性菌和含有白色念珠菌的真菌具有抗微生物活性。 任选和部分修饰或缺失SEQ ID NO:1的氨基酸序列以改善其抗微生物活性。