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1. 发明公开

KR1020030059954A 신규한 닭 전염성 기관지염 바이러스(ＩＢＶ) 및 이를이용한 닭 전염성 기관지염 (ＩＢ) 감염 예방백신 有权
标题翻译： AVIAN感染性BRONCHITIS病毒和使用该疫苗的疫苗
公开(公告)号：KR1020030059954A
公开(公告)日：2003-07-12
申请号：KR1020020000509
申请日：2002-01-04
申请人： 학교법인 건국대학교
发明人： 송창선 , 이윤정 , 김재홍
IPC分类号： C12N7/01
CPC分类号： C12N7/00 , A61K39/215 , A61K2039/5252 , A61K2039/552 , C12N2770/20034
摘要： PURPOSE: Provided is an avian infectious bronchitis virus(IBV) which removes the shortcomings of the existent vaccines where the IBV is used as a vaccine strain, and effectively prevents the domestic IB variant. CONSTITUTION: An IBV K2 low passage (KCTC 10105BP) is characterized by a variant IBV strain and incurring nephropathy. The IBV K2 low passage is attenuated, thereby making an IBV K2 high passage (KCTC 10106BP). An inactivated vaccine is made by inactivating the IBV K2 low passage, and containing it in the pharmaceutically effective amount, whereas an attenuated virus vaccine by attenuating the IBV K2 low passage, and containing it the pharmaceutical effective dosage thereof. The inactivated or attenuated virus vaccine further contains pharmaceutically acceptable carrier or diluent.
摘要翻译：目的：提供一种禽传染性支气管炎病毒（IBV），可消除IBV用作疫苗株的现有疫苗的缺点，有效防止国内IB变种。构成：IBV K2低通量（KCTC 10105BP）的特征在于变异体IBV毒株并引起肾病。 IBV K2低通量被衰减，从而使IBV K2高通量（KCTC 10106BP）。通过灭活IBV K2低通道并以药物有效量含有灭活疫苗，而减毒病毒疫苗通过减弱IBV K2低通道并含有其药物有效剂量来制备。灭活或减毒的病毒疫苗还含有药学上可接受的载体或稀释剂。

2. 发明公开

KR1020020061295A 흑염소 로타 바이러스 순화주, 이의 제조 방법 및 용도 失效
标题翻译：具有恶化病原性影响的黑色山羊皮老化菌株，制备方法及其用途
公开(公告)号：KR1020020061295A
公开(公告)日：2002-07-24
申请号：KR1020010002260
申请日：2001-01-15
申请人： 학교법인 건국대학교
发明人： 김태종 , 이중복 , 박승용 , 송창선 , 김보숙
IPC分类号： C12N7/01
CPC分类号： C12N7/00 , A61K39/15 , A61K2039/5254 , A61K2039/552 , C12N2720/12334 , C12N2720/12362
摘要： PURPOSE: Provided are black goat rotavirus attenuated strain having attenuated pathogenic effect, and its preparation method and use as vaccine for diarrhea caused by rotavirus. CONSTITUTION: Rotavirus attenuated strain(KFCC-11255) is separated from black goat. It is prepared by the steps of: separating rotavirus from black goat; sensitizing the separated virus with trypsin then infecting a host cell therewith; if cell degeneration is created, collecting the cell then followed by freezing and thawing it for cell lysis; centrifuging the cell lysate to obtain rotavirus; and repeating the above process 100 times to obtain rotavirus attenuated strain.
摘要翻译：目的：提供具有减弱病原作用的黑山羊轮状病毒减毒菌株及其制备方法，用作轮状病毒引起的腹泻疫苗。构成：轮状病毒减毒菌株（KFCC-11255）与黑山羊分离。它是通过以下步骤制备的：从黑山羊分离轮状病毒; 用胰蛋白酶致敏分离的病毒，然后用宿主细胞感染宿主细胞; 如果产生细胞变性，收集细胞，然后冷冻和解冻细胞裂解; 离心细胞裂解液得到轮状病毒; 并重复上述过程100次以获得轮状病毒减毒株。

3. 发明公开

KR1020030054139A 돼지 오제스키병 바이러스의 ｇＤ 유전자를 포함하는재조합 발현 벡터 및 이를 이용한 ＤＮＡ 백신 无效
标题翻译：包含苹果病毒病毒的GD基因和使用该酶的DNA疫苗的重组表达载体
公开(公告)号：KR1020030054139A
公开(公告)日：2003-07-02
申请号：KR1020010084256
申请日：2001-12-24
申请人： 학교법인 건국대학교
发明人： 황도윤 , 송재영 , 현방훈 , 박승용 , 이중복 , 송창선 , 김태종
IPC分类号： C12N15/86
CPC分类号： C12N15/85 , C07K14/005 , C12N2710/16734
摘要： PURPOSE: A recombinant expression vector comprising the gD gene of swine Aujeszky's disease virus and a DNA vaccine using the same are provided, thereby effectively preventing the infection of swine Aujeszky's disease virus. CONSTITUTION: A recombinant expression vector pMYK/ADV gD(KCCM-10344) comprises the gene encoding a glycoprotein gD isolated from swine Aujeszky's disease virus, wherein the gD gene has the nucleotide sequence of SEQ ID NO: 1. A DNA vaccine for prevention of the infection of swine Aujeszky's disease virus is prepared by infection of bacteria with the recombinant expression vector pMYK/ADV gD(KCCM-10344).
摘要翻译：目的：提供包含猪Aujeszky病病毒的gD基因和使用其的DNA疫苗的重组表达载体，从而有效地防止猪Aujeszky病病毒的感染。构成：重组表达载体pMYK / ADV gD（KCCM-10344）包含编码从猪Aujeszky病病毒分离的糖蛋白gD的基因，其中gD基因具有SEQ ID NO：1的核苷酸序列。通过用重组表达载体pMYK / ADV gD（KCCM-10344）感染细菌来制备猪Aujeszky病病毒的感染。

4. 发明授权

KR100391265B1 흑염소 로타 바이러스 순화주, 이의 제조 방법 및 용도 失效
标题翻译： 흑염소로타바이러스순화주，이의제조방법및용도흑염및
公开(公告)号：KR100391265B1
公开(公告)日：2003-07-12
申请号：KR1020010002260
申请日：2001-01-15
申请人： 학교법인 건국대학교
发明人： 김태종 , 이중복 , 박승용 , 송창선 , 김보숙
IPC分类号： C12N7/01
摘要： PURPOSE: Provided are black goat rotavirus attenuated strain having attenuated pathogenic effect, and its preparation method and use as vaccine for diarrhea caused by rotavirus. CONSTITUTION: Rotavirus attenuated strain(KFCC-11255) is separated from black goat. It is prepared by the steps of: separating rotavirus from black goat; sensitizing the separated virus with trypsin then infecting a host cell therewith; if cell degeneration is created, collecting the cell then followed by freezing and thawing it for cell lysis; centrifuging the cell lysate to obtain rotavirus; and repeating the above process 100 times to obtain rotavirus attenuated strain.
摘要翻译：目的：提供致病作用减弱的黑山羊轮状病毒减毒株及其制备方法和用作轮状病毒引起的腹泻的疫苗。构成：轮状病毒减毒株（KFCC-11255）与黑山羊分离。它由以下步骤制备：从黑山羊分离轮状病毒; 用胰蛋白酶敏化分离的病毒，然后用其感染宿主细胞; 如果细胞变性产生，收集细胞然后冷冻并解冻以进行细胞裂解; 离心细胞裂解物以获得轮状病毒; 并重复上述过程100次以获得轮状病毒减毒株。

5. 发明公开

KR1020020061300A 흑염소 로타 바이러스 ＶＰ4 및 ＶＰ7의 유전자 및 이의단백질 无效
标题翻译：黑色山羊VP4和VP7基因及蛋白质
公开(公告)号：KR1020020061300A
公开(公告)日：2002-07-24
申请号：KR1020010002265
申请日：2001-01-15
申请人： 학교법인 건국대학교
发明人： 김태종 , 이중복 , 박승용 , 송창선 , 김보숙
IPC分类号： C12N15/64
CPC分类号： C07K14/005 , C12N2720/12322
摘要： PURPOSE: Provided are black goat rotavirus VP4 and VP7 genes and their proteins. The black goat rotavirus VP4 and VP7 genes are used for the diagnosis of and vaccine for rotavirus diarrhea. CONSTITUTION: VP4 and VP7 genes cloning comprises the steps of: extracting total RNA from black goat rotavirus; constructing cDNA; synthesizing a pair of primers specific to VP4 and VP7; performing PCR using cDNA as a template; sequencing PCR products and analyzing homology between the PCR products and each VP4 and VP7. The gene of black goat envelope protein VP4 has the nucleotide sequence of SEQ ID NO;1 and its protein has the amino acid sequence of SEQ ID No:2. The gene of black goat envelop protein VP7 has the nucleotide sequence of SEQ ID NO;3 and its protein has the amino acid sequence of SEQ ID NO;4.
摘要翻译：目的：提供黑色山羊轮状病毒VP4和VP7基因及其蛋白质。黑山羊轮状病毒VP4和VP7基因用于轮状病毒腹泻的诊断和疫苗。构成：VP4和VP7基因克隆包括以下步骤：从黑山羊轮状病毒中提取总RNA; 构建cDNA; 合成VP4和VP7特异性的一对引物; 使用cDNA作为模板进行PCR; 测序PCR产物并分析PCR产物与每个VP4和VP7之间的同源性。黑山羊包膜蛋白VP4的基因具有SEQ ID NO：1的核苷酸序列，其蛋白质具有SEQ ID No：2的氨基酸序列。黑山羊包膜蛋白VP7的基因具有SEQ ID NO：3的核苷酸序列，其蛋白质具有SEQ ID NO：4的氨基酸序列。

6. 发明授权

KR100468037B1 신규한 닭 전염성 기관지염 바이러스(ＩＢＶ) 및 이를이용한 닭 전염성 기관지염 (ＩＢ) 감염 예방백신 有权
标题翻译： 신규한닭전염성기관지염바이러스（IBV）및이를이용한닭전염성기관지염（IB）감염예방백신
公开(公告)号：KR100468037B1
公开(公告)日：2005-01-24
申请号：KR1020020000509
申请日：2002-01-04
申请人： 학교법인 건국대학교
发明人： 송창선 , 이윤정 , 김재홍
IPC分类号： C12N7/01
摘要： PURPOSE: Provided is an avian infectious bronchitis virus(IBV) which removes the shortcomings of the existent vaccines where the IBV is used as a vaccine strain, and effectively prevents the domestic IB variant. CONSTITUTION: An IBV K2 low passage (KCTC 10105BP) is characterized by a variant IBV strain and incurring nephropathy. The IBV K2 low passage is attenuated, thereby making an IBV K2 high passage (KCTC 10106BP). An inactivated vaccine is made by inactivating the IBV K2 low passage, and containing it in the pharmaceutically effective amount, whereas an attenuated virus vaccine by attenuating the IBV K2 low passage, and containing it the pharmaceutical effective dosage thereof. The inactivated or attenuated virus vaccine further contains pharmaceutically acceptable carrier or diluent.
摘要翻译：目的：提供一种禽传染性支气管炎病毒（IBV），其消除了将IBV用作疫苗株的现有疫苗的缺点，并且有效地阻止了国内IB变体。组成：IBV K2低传代（KCTC 10105BP）的特征是变异的IBV株并引发肾病。 IBV K2低通道衰减，从而形成IBV K2高通道（KCTC 10106BP）。通过灭活IBV K2低通道并以药物有效量包含它来制备灭活疫苗，而通过减毒IBV K2低通道并包含其药物有效剂量的减毒病毒疫苗来制备灭活疫苗。灭活的或减毒的病毒疫苗还含有药学上可接受的载体或稀释剂。

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