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    • 4. 发明公开
    • 글루코스 유도체에 방사성 동위원소가 표지된 착화합물 및이를 생산하기 위한 조성물이 포함된 키트
    • 用放射性同位素标记的葡萄糖衍生物复合物及其制造方法
    • KR1020010092163A
    • 2001-10-24
    • KR1020000014214
    • 2000-03-21
    • 재단법인 아산사회복지재단
    • 이희경문대혁류진숙김재승오승준
    • C07D335/02
    • A61K51/0491C07H5/06C07H5/10C07H23/00
    • PURPOSE: Provided is a glucose derivative complex compound in which the glucose derivative contains nitrogen or sulfur atom in its molecule, and is labeled with a radioactive isotope. And, a kit article including the glucose derivative and a reductant is also provided to produce the same. The compound has an excellent absorbability into a tumor region and is produced cost effectively, thereby being useful as a diagnosis reagent for tumor. CONSTITUTION: In a glucose derivative complex compound, the glucose derivative containing nitrogen or sulfur atom in its molecule is labeled with at least one radioactive isotope selected from the group of(99m)Tc,(188)Re, and(186)Re. Wherein, the glucose derivative is selected from the group consisting of 1-thio-D-glucose, 5-thio-D-glucose, glucosamine, and their salts or hydrates. The kit article comprises the glucose derivative including nitrogen or sulfur atom in its molecule and a reductant selected from the group of tin chloride(II), formamidine sulfuric acid, sulfuric acid and sodium borohydride. Optionally it includes an additive selected from the group consisting of ascorbic acid, sodium bisulphite and sodium pyrosulphite.
    • 目的:提供葡萄糖衍生物复合物,其中葡萄糖衍生物在其分子中含有氮或硫原子,并用放射性同位素标记。 并且还提供包含葡萄糖衍生物和还原剂的试剂盒制品以制备其。 该化合物对肿瘤区域具有优异的吸收性,并且成本有效地生产,因此可用作肿瘤的诊断试剂。 构成:在葡萄糖衍生物络合物中,其分子中含有氮或硫原子的葡萄糖衍生物用至少一种选自(99m)Tc,(188)Re和(186)Re的放射性同位素标记。 其中葡萄糖衍生物选自1-硫代-D-葡萄糖,5-硫代-D-葡萄糖,葡糖胺及其盐或水合物。 试剂盒制品包括其分子中包含氮或硫原子的葡萄糖衍生物和选自氯化锡(II),甲脒硫酸,硫酸和硼氢化钠的还原剂。 任选地,它包括选自抗坏血酸,亚硫酸氢钠和焦亚硫酸钠的添加剂。