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1. 发明公开

KR1020050062565A 유전자 발현을 위한 핵산 구조물 无效
标题翻译：用于基因表达的核酸构建体
公开(公告)号：KR1020050062565A
公开(公告)日：2005-06-23
申请号：KR1020057005199
申请日：2003-09-29
申请人： 파우더젝트 리서치 리미티드
发明人： 브라운,랄프패트릭
IPC分类号： C12N15/86 , C12N15/869
CPC分类号： C12N15/87 , A61K2039/53 , C12N15/85 , C12N15/86 , C12N2710/16643 , C12N2830/60
摘要： Nucleic acid constructs comprising viral genomic nucleic acid which comprises at least two endogenous gene expression regulatory units which each comprise an endogenous promoter where the endogenous promoters of the units are active at the same phase in the viral life cycle of the virus the viral genomic nucleic acid is derived from are provided. The endogenous gene expression regulatory units are used to express particular chosen heterologous coding sequences and in particular to express heterologous antigens. The constructs can be used in a vaccine to generate an immune response against the heterologous antigens and in particular may be used in a DNA vaccine. Methods for generating the constructs and means for their administration are also provided.
摘要翻译：包含病毒基因组核酸的核酸构建体，其包含至少两个内源基因表达调节单元，每个内含基因表达调节单元包含内源性启动子，其中所述单元的内源启动子在病毒的病毒生命周期中的相同阶段是有活性的病毒基因组核酸提供。内源性基因表达调控单元用于表达特定选择的异源编码序列，特别是表达异源抗原。构建体可用于疫苗中以产生针对异源抗原的免疫应答，并且特别可用于DNA疫苗。还提供了用于产生构建体的方法和用于其施用的方法。

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