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1. 发明公开

KR1020130093424A 장미꽃 추출물을 유효성분으로 포함하는 허혈성 뇌질환 치료용 조성물 有权
标题翻译：用于治疗包含从玫瑰花提取物作为活性成分的异常脑疾病的组合物
公开(公告)号：KR1020130093424A
公开(公告)日：2013-08-22
申请号：KR1020120015038
申请日：2012-02-14
申请人： 충북대학교 산학협력단
发明人： 김윤배 , 박동선
IPC分类号： A61K36/73 , A61P9/00 , A61P25/00
CPC分类号： A61K36/738 , A23V2200/322 , A61K2236/33
摘要： PURPOSE: A composition for ischemic brain disease treatment is provided to reduce the size of cerebral edema and cerebral infarction domain, to reduce the level of lipid peroxidation and encephalopathy, and to show a brain protecting activation, thereby realizing a possibility of being developed as a therapeutic agent for ischemic brain disease. CONSTITUTION: A composition for preventing or curing ischemic brain disease comprises Rosa hybrid extract as an active ingredient. The rosa hybrid extract is a solvent extract extracted by using more than one solvent selected from a group comprising water, 1-4 carbon numbers of hydrated or non-hydrated lower alcohol, acetone, ethyl acetate, butylacetate, chloroform, hexane, diethylether, and 1,3- butylene glycol. The ischemic brain disease is stroke, cerebral infarction, cerebral ischemia, hypoxia brain damage, or traumatic brain injury. A food composition for improving ischemic brain disease comprises the rosa hybrid extract as an active ingredient.
摘要翻译：目的：提供缺血性脑疾病治疗组合物，以减少脑水肿和脑梗死面积的大小，降低脂质过氧化和脑病的水平，并显示大脑保护活化，从而实现发展为缺血性脑病治疗剂。构成：用于预防或治愈缺血性脑病的组合物，其中罗莎混合提取物为活性成分。罗莎混合提取物是通过使用多于一种选自水，1-4碳数的水合或非水合的低级醇，丙酮，乙酸乙酯，乙酸丁酯，氯仿，己烷，乙醚和 1,3-丁二醇。缺血性脑病是脑卒中，脑梗死，脑缺血，缺氧性脑损伤或创伤性脑损伤。用于改善缺血性脑病的食物组合物包含罗莎混合提取物作为活性成分。

2. 发明授权

KR101384351B1 장미꽃 추출물을 유효성분으로 포함하는 허혈성 뇌질환 치료용 조성물 有权
标题翻译：用于治疗缺血性脑病的组合物，其包含玫瑰花提取物作为活性成分
公开(公告)号：KR101384351B1
公开(公告)日：2014-04-14
申请号：KR1020120015038
申请日：2012-02-14
申请人： 충북대학교 산학협력단
发明人： 김윤배 , 박동선
IPC分类号： A61K36/73 , A61P9/00 , A61P25/00
摘要： 본 발명은 장미꽃 추출물을 유효성분으로 포함하는 허혈성 뇌질환의 예방, 치료 또는 개선용 조성물에 관한 것이다. 본 발명의 활성성분인 장미꽃 추출물은 중뇌동맥폐색 및 재관류에 의해 유도된 허혈성 뇌손상에서 뇌경색 영역 및 뇌부종의 크기를 감소시키고, 지질과산화 및 뇌염증 수준을 낮추며, 뇌손상 및 행동장애를 크게 개선시키는 뇌보호 활성을 나타낸다. 따라서, 본 발명의 조성물은 허혈성 뇌질환의 치료제로 개발될 수 있다.

3. 发明公开

KR1020110072153A 백장미 꽃 추출물을 유효성분으로 포함하는 조성물 无效
标题翻译：作为活性成分的白色玫瑰花提取物的组合物
公开(公告)号：KR1020110072153A
公开(公告)日：2011-06-29
申请号：KR1020090128981
申请日：2009-12-22
申请人： 충북대학교 산학협력단
发明人： 주성수 , 김윤배 , 박동선 , 전정희 , 황석연
IPC分类号： A61K36/73 , A61P39/06 , A61K8/97 , A23L1/30
摘要： PURPOSE: An antioxidative and antibacterial composition containing Rosa rugosa var. alba flower extract is provided to remove free radical and to suppress DNA fragmentation and apoptosis. CONSTITUTION: An antioxidative composition contains Rosa rugosa var. alba flower extract as an active ingredient. The extract is isolated using water, anhydrous or hydrous alcohol of 1-6 carbon atoms, hexane, acetone, ethyl acetate, butyl acetate, 1,3-butylene glycol, or mixture solvent thereof. The extract contains cyclododecane or dodecyl acrylate. The composition is a cosmetic composition or functional food composition.
摘要翻译：目的：抗氧化和抗菌成分含有罗莎，提供阿尔巴花提取物以去除自由基并抑制DNA断裂和凋亡。构成：抗氧化组合物含有罗莎（Rosa rugosa var。阿尔巴花提取物作为活性成分。使用1-6个碳原子的水，无水或含水醇，己烷，丙酮，乙酸乙酯，乙酸丁酯，1,3-丁二醇或其混合溶剂分离提取物。提取物含有环十二烷或丙烯酸十二烷基酯。组合物是化妆品组合物或功能性食品组合物。

4. 发明公开

KR1020100062488A 레스베라트롤의 기형아 출산 방지방법 无效
标题翻译：通过RESVERATROL预防恶性儿童的方法
公开(公告)号：KR1020100062488A
公开(公告)日：2010-06-10
申请号：KR1020080121141
申请日：2008-12-02
申请人： 충북대학교 산학협력단
发明人： 김윤배 , 장자영 , 박동선 , 최병일 , 전정희 , 신선희
IPC分类号： A61K31/05 , A61P43/00
摘要： PURPOSE: A method for preventing deformed child using resveratrol is provided to prevent parent toxicity and deformation of mouse fetus caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin. CONSTITUTION: A method for preventing deformed child is performed by oral administration of resveratrol to deformed mouse fetus caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD). The deformation of mouse fetus is cleft palate, pyelectasia, urethra expansion, or urethra skew. TCDD blocks sex hormone secretion and suppresses male reproductive organ.
摘要翻译：目的：提供一种防止变形儿童使用白藜芦醇的方法，以防止由2,3,7,8-四氯二苯并对二恶英引起的小鼠胎儿的亲本毒性和变形。构成：通过将2,3,7,8-四氯二苯并对二恶英（TCDD）引起的白藜芦醇口服给变形的小鼠胎儿进行防止变形的儿童的方法。小鼠胎儿的变形是腭裂，青光眼，尿道扩张或尿道偏斜。 TCDD阻断性激素分泌并抑制男性生殖器官。

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