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    • 4. 发明授权
    • 항진균제의 검색방법
    • 항진균제의검색방법
    • KR100400877B1
    • 2003-10-08
    • KR1020000058565
    • 2000-10-05
    • 백융기(주)케이디알
    • 백융기김중호김기영신유경
    • C12Q1/48
    • PURPOSE: A method for screening of fungicide is provided, which method can be effectively used in developing new medicines having fungicidal effects. CONSTITUTION: The method for measuring activity of fungal acyl CoA:sterol acyl transferase comprises the steps of: reacting fungal acyl CoA:sterol acyl transferase(ASAT) with sterol and acyl group as substrates; and determining the amount of sterol ester as a product of the reaction. The method for screening fungal acyl CoA:sterol acyl transferase comprises the steps of: cultivating fungal cell; treating the cultivated fungal cell with a substance assumed as an acyl CoA:sterol acyl transferase(ASAT) inhibitor; and determining the amount of oleic acid in the substance treated medium, in which the amount of oleic acid can be analyzed by using a liquid scintillation counter.
    • 目的:提供一种筛选杀真菌剂的方法,该方法可有效用于开发具有杀真菌作用的新药。 构成:测量真菌酰基CoA:甾醇酰基转移酶活性的方法包括以下步骤:使真菌酰基CoA:甾醇酰基转移酶(ASAT)与甾醇和酰基作为底物; 并确定作为反应产物的甾醇酯的量。 筛选真菌酰基CoA:甾醇酰基转移酶的方法包括以下步骤:培养真菌细胞; 用假定为酰基CoA:甾醇酰基转移酶(ASAT)抑制剂的物质处理栽培的真菌细胞; 并测定物质处理过的介质中油酸的量,其中可以用液体闪烁计数器分析油酸的量。
    • 8. 发明公开
    • 항진균제의 검색방법
    • 筛选杀真菌剂的方法
    • KR1020020027849A
    • 2002-04-15
    • KR1020000058565
    • 2000-10-05
    • 백융기(주)케이디알
    • 백융기김중호김기영신유경
    • C12Q1/48
    • PURPOSE: A method for screening of fungicide is provided, which method can be effectively used in developing new medicines having fungicidal effects. CONSTITUTION: The method for measuring activity of fungal acyl CoA:sterol acyl transferase comprises the steps of: reacting fungal acyl CoA:sterol acyl transferase(ASAT) with sterol and acyl group as substrates; and determining the amount of sterol ester as a product of the reaction. The method for screening fungal acyl CoA:sterol acyl transferase comprises the steps of: cultivating fungal cell; treating the cultivated fungal cell with a substance assumed as an acyl CoA:sterol acyl transferase(ASAT) inhibitor; and determining the amount of oleic acid in the substance treated medium, in which the amount of oleic acid can be analyzed by using a liquid scintillation counter.
    • 目的:提供一种筛选杀菌剂的方法,该方法可有效用于开发具有杀真菌作用的新药。 构成:用于测定真菌酰基辅酶A:固醇酰基转移酶活性的方法包括以下步骤:使真菌酰基辅酶A:固醇酰基转移酶(ASAT)与固醇和酰基作为底物反应; 并测定作为反应产物的甾醇酯的量。 筛选真菌酰基辅酶A:固醇酰基转移酶的方法包括以下步骤:培养真菌细胞; 用假定为酰基CoA:甾醇酰基转移酶(ASAT)抑制剂的物质处理培养的真菌细胞; 并测定物质处理过的介质中油酸的量,其中油酸的量可以通过使用液体闪烁计数器进行分析。
    • 10. 发明公开
    • 약학적으로 유용한 노화 및 스트레스 조절용 신규 페로몬 화합물 및 그 분리정제방법
    • 具有老化和应力控制活性的PHEROMONE化合物及其分离方法
    • KR1020040042338A
    • 2004-05-20
    • KR1020020070591
    • 2002-11-14
    • 백융기(주)케이디알
    • 정판영백융기
    • C07D309/12
    • C07D309/10C07H15/04
    • PURPOSE: Pheromone compound having aging and stress controlling activities, and a process for isolating the same are provided, which compound is useful for studies on aging and stress, metabolism pathway and signal transfer system, and disease development mechanism. CONSTITUTION: A pheromone compound, 6-(3,5-dihydroxy-6 -methyl-tetrahydro -pyran-2-yloxy) -heptanoic acid, having aging and stress controlling activities is represented by the formula(1). A process for isolating the pheromone compound of the formula(1) comprises the steps of: growing C. elegans in S basal broth medium, concentrating the medium and extracting the concentrated medium with ethanol; dissolving the extract in water and extracting the solution with ethylacetate; removing impurities using silica-gel adsorption chromatography; subjecting the active fraction to HPLC(High performance liquid chromatography) coupled with amine residue; and subjecting the active fraction to HPLC using the molecular weight size.
    • 目的:提供具有老化和应激控制活性的信息素化合物及其分离方法,该化合物可用于老化和应激,代谢途径和信号转导系统的研究以及疾病发展机制。 构成:具有老化和应力控制活性的信息素化合物6-(3,5-二羟基-6-甲基 - 四氢 - 吡喃-2-基氧基) - 庚酸由式(1)表示。 分离式(1)的信息素化合物的方法包括以下步骤:在S基础培养基培养基中生长秀丽隐杆线虫,浓缩培养基并用乙醇萃取浓缩培养基; 将提取物溶解在水中并用乙酸乙酯萃取溶液; 使用硅胶吸附色谱去除杂质; 使活性级分与胺残留物进行HPLC(高效液相色谱)反应; 并使用分子量大小使活性部分进行HPLC。