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1. 发明公开

KR1020020085606A 먹장어 피부로부터 분리한 새로운 항균활성 펩타이드들 및 그것들의 유사체들 失效
标题翻译：从HAGFISH，EPTATRETUS BURGERI及其模拟物的皮肤分离的抗微生物肽
公开(公告)号：KR1020020085606A
公开(公告)日：2002-11-16
申请号：KR1020010025191
申请日：2001-05-09
申请人： 주식회사 필켐
发明人： 박남규 , 서정길 , 한선홍 , 권세영
IPC分类号： C07K7/06
CPC分类号： C07K7/06 , A01N33/00 , C07K1/14
摘要： PURPOSE: Antimicrobial peptides isolated from the skin of Hagfish, Eptatretus burgeri, and their analogs are provided, therefore the antimicrobial peptides have high antimicrobial activity on various bacteria and do not cause hemolysis of a red cell. CONSTITUTION: The antimicrobial peptides isolated from the skin of Hagfish, Eptatretus burgeri contain at least 8 amino acid sequence represented by P- W- X1- X2- Y- X3- K- Y, P- W- X1- X2- S- X3- K- Y, or W- X1- X2- Y- X3- K- Y- R, wherein X1, X2 and X3 are any amino acids; the antimicrobial peptide is selected from the group consisting of the nucleotide sequences represented by SEQ ID NOs: 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10, respectively; the C-terminal of the amino acid sequence is amidated; an amine group in the N-terminal of the amino acid sequence is substituted by alkyl or acetyl; the amino acid residues of the amino acid sequence is L-type or D-type; and the hydrophobic moment of the antimicrobial peptide is 0.15 to 0.8.
摘要翻译：目的：提供从Hagfish，Eptatretus burgeri及其类似物皮肤分离的抗菌肽，因此抗菌肽对各种细菌具有高抗微生物活性，不会引起红细胞溶血。构成：从Hagfish，Eptatretus burgeri的皮肤分离的抗微生物肽含有由P- W-X1- X2-Y-X3-K-Y，P- W-X1- X2-S-X3表示的至少8个氨基酸序列 - K-Y或W-X1- X2-Y-X3-K-Y-R，其中X1，X2和X3是任何氨基酸; 抗微生物肽分别选自由SEQ ID NO：1,2,3,4,5,6,7,8,9和10表示的核苷酸序列; 氨基酸序列的C-末端酰胺化; 氨基酸序列的N-末端的胺基被烷基或乙酰基取代; 氨基酸序列的氨基酸残基是L型或D型; 抗微生物肽的疏水力矩为0.15〜0.8。

2. 发明授权

KR100465588B1 먹장어 피부로부터 분리한 새로운 항균활성 펩타이드들 및 그것들의 유사체들 失效
标题翻译： 먹장어피부로항균운활활이이들들및것들것들것들들들들들들들들먹들들들들들
公开(公告)号：KR100465588B1
公开(公告)日：2005-01-13
申请号：KR1020010025191
申请日：2001-05-09
申请人： 주식회사 필켐
发明人： 박남규 , 서정길 , 한선홍 , 권세영
IPC分类号： C07K7/06
摘要： PURPOSE: Antimicrobial peptides isolated from the skin of Hagfish, Eptatretus burgeri, and their analogs are provided, therefore the antimicrobial peptides have high antimicrobial activity on various bacteria and do not cause hemolysis of a red cell. CONSTITUTION: The antimicrobial peptides isolated from the skin of Hagfish, Eptatretus burgeri contain at least 8 amino acid sequence represented by P- W- X1- X2- Y- X3- K- Y, P- W- X1- X2- S- X3- K- Y, or W- X1- X2- Y- X3- K- Y- R, wherein X1, X2 and X3 are any amino acids; the antimicrobial peptide is selected from the group consisting of the nucleotide sequences represented by SEQ ID NOs: 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10, respectively; the C-terminal of the amino acid sequence is amidated; an amine group in the N-terminal of the amino acid sequence is substituted by alkyl or acetyl; the amino acid residues of the amino acid sequence is L-type or D-type; and the hydrophobic moment of the antimicrobial peptide is 0.15 to 0.8.
摘要翻译：目的：提供从海鳗，Eptatretus burgeri及其类似物的皮肤分离的抗菌肽，因此抗菌肽对各种细菌具有高抗菌活性并且不会引起红细胞的溶血。构成：从Hagfish，Eptatretus burgeri的皮肤分离的抗微生物肽含有至少8个由P-W-X1-X2-Y-X3-K-Y，P-W-X1-X2-S-X3 -K-Y或W-X1-X2-Y-X3-K-Y-R，其中X1，X2和X3是任何氨基酸; 抗微生物肽选自由分别由SEQ ID NO：1,2,3,4,5,6,7,8,9和10表示的核苷酸序列组成的组; 氨基酸序列的C末端被酰胺化; 氨基酸序列N端的胺基被烷基或乙酰基取代; 氨基酸序列的氨基酸残基是L型或D型; 并且抗微生物肽的疏水性矩为0.15至0.8。

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