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    • 9. 发明公开
    • 글리코겐 합성효소 인산화효소-3 억제제를 유효성분으로 포함하는 청각 세포 손상 보호용 조성물
    • 用于保护包含GLYCOGEN SYNTHASE KINASE-3抑制剂作为活性成分的审核细胞的损伤的组合物
    • KR1020100062647A
    • 2010-06-10
    • KR1020080121372
    • 2008-12-02
    • 주식회사 케미메디
    • 박성주송호준황성연박래길
    • A61K33/14A61P35/00
    • PURPOSE: A composition containing a glycogen synthase kinase-3 inhibitor is provided to suppress apoptosis and to reduce auditory cell injury. CONSTITUTION: A composition for protecting auditory cells contains glycogen synthase kinase(GSK-3) inhibitor as an active ingredient. The GSK-3 inhibitor is SB216763 or LiCl. A composition for preventing and treating cancer contains cisplatin and GSK-3 inhibitor as active ingredient. A method for screening an agent for preventing and relieving auditory cell injury by cisplatin administration comprises: a step of pre-culturing cells which express GSK-3 polypeptide with or without test agent; a step of measuring GSK-3 activity in the pre-cultured cells together with test agent; and a step of comparing activity degree of GSK-3.
    • 目的:提供含有糖原合酶激酶-3抑制剂的组合物以抑制细胞凋亡并减少听觉细胞损伤。 构成:用于保护听觉细胞的组合物含有糖原合酶激酶(GSK-3)抑制剂作为活性成分。 GSK-3抑制剂是SB216763或LiCl。 用于预防和治疗癌症的组合物含有顺铂和GSK-3抑制剂作为活性成分。 通过顺铂给药来筛选用于预防和缓解听觉细胞损伤的药剂的方法包括:用或不用测试剂预培养表达GSK-3多肽的细胞的步骤; 与测试试剂一起测量预培养细胞中的GSK-3活性的步骤; 并比较GSK-3的活动程度。