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2. 发明公开

KR1020120114174A 1-(3-시아노-1-아이소프로필-인돌-5-일)피라졸-4-카르복실산의 결정형과 그의 제조방법 有权
标题翻译： 1-（3-氰基-1-异丙基吲哚-5-基）吡唑-4-羧酸结晶形式及其制备方法
公开(公告)号：KR1020120114174A
公开(公告)日：2012-10-16
申请号：KR1020120035349
申请日：2012-04-05
申请人： 주식회사 엘지생명과학
发明人： 윤정민 , 박기숙 , 윤주용 , 이주영 , 김근태 , 정철규
IPC分类号： C07D403/04 , A61K31/4155 , A61P3/00 , A61P9/00
CPC分类号： C07D403/04
摘要： PURPOSE: A crystalline form of a compound and a method for preparing the same are provided to selectively suppress xanthine oxidase and to ensure thermal stability and storage stability. CONSTITUTION: A crystalline form of 1-(3-cyano-1-isopropyl-indole-5-yl)pyrazole-4-carboxylic acid is denoted by formula 1. A method for preparing the crystalline form of the compound of formula 1 comprises a step of dissolving the compound of chemical formula 1 in a solvent and crystallizing. The solvent includes anhydrous ethanol, 2-methoxy ethanol, isobutanol, n-butanol, n-octanol, n-propanol, isopropanol, t-butanol, acetic acid, acetone, butyl acetate, methyl acetate, ethyl acetate, propyl acetate, t-butyl acetate, isobutyl acetate, methyl ethyl ketone, 2-pentanone, tetrahydrofurane, acetonitrile, chloroform, toluene, or a mixture thereof.
摘要翻译：目的：提供化合物的结晶形式及其制备方法以选择性地抑制黄嘌呤氧化酶并确保热稳定性和储存稳定性。组成：1-（3-氰基-1-异丙基 - 吲哚-5-基）吡唑-4-羧酸的结晶形式由式1表示。制备式1化合物的结晶形式的方法包括将化学式1的化合物溶解在溶剂中并结晶的步骤。溶剂包括无水乙醇，2-甲氧基乙醇，异丁醇，正丁醇，正辛醇，正丙醇，异丙醇，叔丁醇，乙酸，丙酮，乙酸丁酯，乙酸甲酯，乙酸乙酯，乙酸丙酯，乙酸丁酯，乙酸异丁酯，甲基乙基酮，2-戊酮，四氢呋喃，乙腈，氯仿，甲苯或其混合物。

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