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1. 发明授权

KR100465977B1 나노유화기술에 의한 화합물 Ｋ를 함유하는 미세 유화 입자 및 이를 사용한 피부 외용제 조성물 有权
标题翻译： 나노유화기술에의한화합물K를함유하는미세유화입자및이를사용한피부외용제조성물
公开(公告)号：KR100465977B1
公开(公告)日：2005-01-13
申请号：KR1020020000614
申请日：2002-01-05
申请人： 주식회사 아모레퍼시픽그룹
发明人： 유병희 , 강병영 , 염명훈 , 성대석 , 주희경 , 한상훈 , 김한곤
IPC分类号： A61K8/11 , A61K8/65 , A61Q19/00 , B82Y5/00
摘要： PURPOSE: An external agent composition for application to the skin is provided which contains a compound K prepared by bioconversion of ginseng saponin as an effective ingredient. By the inclusion of the compound K as a major metabolite of Panax Ginseng into nanoemulsions or liposomes using nanoemulsion techniques, the agent composition has improved transdermal absorption and excellent skin aging-preventing effect such as wrinkle abatement. CONSTITUTION: An external skin agent composition contains 10¬-8 to 99.00% by weight of nanoemulsion particles, the nanoemulsion particles contain 0.001 to 30% by weight of a compound K of the formula 1. The compound K is prepared by acid hydrolysis, base hydrolysis or enzyme hydrolysis of a Panax Ginseng extract. The nanoemulsion particles having an average particle size of 30 to 500nm include liposomes containing lecithin, a lecithin derivative and a co-emulsifier.
摘要翻译：目的：提供一种施用于皮肤的外用剂组合物，其含有通过生物转化人参皂苷作为有效成分而制备的化合物K. 通过使用纳米乳剂技术将化合物K作为人参的主要代谢物纳入纳米乳剂或脂质体中，所述剂组合物具有改善的透皮吸收和优异的皮肤老化防止效果，例如减少皱纹。组成：外用皮肤剂组合物含有10 -8重量％至99.00重量％的纳米乳液颗粒，纳米乳液颗粒含有0.001至30重量％的式1化合物K.化合物K通过酸水解，碱人参提取物的水解或酶水解。平均粒径为30-500nm的纳米乳液颗粒包括含有卵磷脂，卵磷脂衍生物和辅助乳化剂的脂质体。

2. 发明授权

KR100465976B1 나노유화기술에 의해 진세노사이드 Ｆ1을 함유하는 미세 유화 입자 및 이를 사용한 피부 외용제 조성물 有权
标题翻译： 나노유화기술에의해진세노사이드F1을함유하하는미세유화입자및이를사용한피부외용제조성물
公开(公告)号：KR100465976B1
公开(公告)日：2005-01-13
申请号：KR1020020000613
申请日：2002-01-05
申请人： 주식회사 아모레퍼시픽그룹
发明人： 유병희 , 강병영 , 염명훈 , 성대석 , 주희경 , 한상훈 , 김한곤
IPC分类号： A61K8/35 , A61Q19/08 , B82Y5/00
摘要： PURPOSE: An external agent composition for application to the skin is provided which is maximized in skin absorption by containing ginsenoside F1 as a major metabolite of Panax Ginseng prepared by a bioconversion process within nanoemulsions or liposomes using nanoemulsion techniques. Therefore, the external skin agent composition has improved transdermal absorption rate and an excellent skin aging-preventing effect such as wrinkle abatement. CONSTITUTION: An external skin agent composition contains 10¬-8 to 99.00% by weight of nanoemulsion particles having an average particle size of 30 to 500nm. The nanoemulsion particles contain 10¬-8 to 99.00% by weight of ginsenoside F1 of the formula 1 as an effective ingredient through nanoemulsion techniques, wherein the ginsenoside F1 is prepared by bioconversion of ginseng saponin and removal of sugar.
摘要翻译：目的：提供一种用于皮肤的外用剂组合物，其通过含有人参皂甙F1作为通过纳米乳剂或脂质体内的生物转化方法使用纳米乳液技术制备的人参的主要代谢物而在皮肤吸收方面达到最大化。因此，外用皮肤剂组合物具有改善的透皮吸收率和优异的皮肤老化防止效果，例如减少皱纹。构成：外用皮肤剂组合物含有10重量％〜8重量％〜99.00重量％的平均粒度为30〜500nm的纳米乳液颗粒。纳米乳剂颗粒通过纳米乳液技术含有10重量％〜8重量％〜99.00重量％的式1的人参皂苷F1作为有效成分，其中人参皂苷F1通过生物转化人参皂苷并除去糖来制备。

3. 发明授权

KR100422760B1 열방성 액정 고분자 마이크로캡슐 및 이의 제조방법, 및이 마이크로캡슐을 함유하는 화장료 조성물 有权
标题翻译： 열방성액정고분자마이로로캡슐및이의제조방법，및이마이로로캡슐을함유하는화장료조성물
公开(公告)号：KR100422760B1
公开(公告)日：2004-03-16
申请号：KR1020010064664
申请日：2001-10-19
申请人： 주식회사 아모레퍼시픽그룹
发明人： 주희경 , 김진웅 , 한상훈 , 장이섭 , 김한곤 , 강학희 , 이옥섭
IPC分类号： B01J13/14 , A61K8/00 , A61K8/11 , B01J13/02
摘要： PURPOSE: Provided are thermotropic liquid crystal polymer microcapsules, a method for preparing the same and cosmetic composition containing the same microcapsules capable of allowing the liquid crystal to maintain its phase behavior in a polymer. CONSTITUTION: The method comprises the steps of (a) dissolving thermotropic liquid crystal and monomers in a solvent and adding initiators to the solvent using supersonic waves, (b) feeding the solution of the step (a) to an aqueous solution containing dispersion stabilizing agent, (c) emulsifying the solution of the step (b), thereby obtaining emulsion, and (d) adding retarder to the emulsion and causing suspension polymerization, thereby obtaining thermotropic liquid crystal polymer capsules.
摘要翻译：目的：提供了热致液晶聚合物微胶囊，其制备方法和包含相同微胶囊的化妆品组合物，所述微胶囊能够使液晶在聚合物中保持其相行为。（a）将步骤（a）的溶液加入到含有分散稳定剂（c）将步骤（b）的溶液乳化，从而获得乳液，和（d）向该乳液中加入缓凝剂并引起悬浮聚合，从而获得热致液晶聚合物胶囊。

4. 发明公开

KR1020030060018A 나노유화기술에 의한 화합물 Ｋ를 함유하는 미세 유화 입자 및 이를 사용한 피부 외용제 조성물 有权
标题翻译：纳米化学技术含有化合物K的纳米颗粒和用于皮肤的外用剂组合物
公开(公告)号：KR1020030060018A
公开(公告)日：2003-07-12
申请号：KR1020020000614
申请日：2002-01-05
申请人： 주식회사 아모레퍼시픽그룹
发明人： 유병희 , 강병영 , 염명훈 , 성대석 , 주희경 , 한상훈 , 김한곤
IPC分类号： A61K8/11 , A61K8/65 , A61Q19/00 , B82Y5/00
CPC分类号： A61K8/63 , A61K8/14 , A61K8/553 , A61K8/66 , A61Q19/00 , A61Q19/08 , B82Y5/00
摘要： PURPOSE: An external agent composition for application to the skin is provided which contains a compound K prepared by bioconversion of ginseng saponin as an effective ingredient. By the inclusion of the compound K as a major metabolite of Panax Ginseng into nanoemulsions or liposomes using nanoemulsion techniques, the agent composition has improved transdermal absorption and excellent skin aging-preventing effect such as wrinkle abatement. CONSTITUTION: An external skin agent composition contains 10¬-8 to 99.00% by weight of nanoemulsion particles, the nanoemulsion particles contain 0.001 to 30% by weight of a compound K of the formula 1. The compound K is prepared by acid hydrolysis, base hydrolysis or enzyme hydrolysis of a Panax Ginseng extract. The nanoemulsion particles having an average particle size of 30 to 500nm include liposomes containing lecithin, a lecithin derivative and a co-emulsifier.
摘要翻译：目的：提供一种适用于皮肤的外用剂组合物，其含有通过人参皂苷生物转化制备的化合物K作为有效成分。通过使用纳米乳液技术将化合物K作为人参的主要代谢物纳入纳米乳剂或脂质体中，所述药剂组合物具有改善的经皮吸收和优异的皮肤老化防止效果，例如皱纹消除。构成：外用皮肤剂组合物含有10〜8〜99.00重量％的纳米乳剂颗粒，纳米乳剂颗粒含有0.001〜30重量％的式1化合物K.化合物K是通过酸水解，碱人参提取物的水解或酶水解。平均粒径为30〜500nm的纳米乳剂粒子包含含有卵磷脂，卵磷脂衍生物和辅助乳化剂的脂质体。

5. 发明公开

KR1020030033224A 열방성 액정 고분자 마이크로캡슐 및 이의 제조방법, 및이 마이크로캡슐을 함유하는 화장료 조성물 有权
标题翻译：热变性液晶聚合物微球，其制备方法和含有热液晶聚合物微球的化妆品组合物
公开(公告)号：KR1020030033224A
公开(公告)日：2003-05-01
申请号：KR1020010064664
申请日：2001-10-19
申请人： 주식회사 아모레퍼시픽그룹
发明人： 주희경 , 김진웅 , 한상훈 , 장이섭 , 김한곤 , 강학희 , 이옥섭
IPC分类号： B01J13/14 , A61K8/00 , A61K8/11 , B01J13/02
CPC分类号： B01J13/14 , A61K8/0295 , A61K8/11 , A61K8/347 , A61K8/355 , A61K8/67 , A61K2800/412
摘要： PURPOSE: Provided are thermotropic liquid crystal polymer microcapsules, a method for preparing the same and cosmetic composition containing the same microcapsules capable of allowing the liquid crystal to maintain its phase behavior in a polymer. CONSTITUTION: The method comprises the steps of (a) dissolving thermotropic liquid crystal and monomers in a solvent and adding initiators to the solvent using supersonic waves, (b) feeding the solution of the step (a) to an aqueous solution containing dispersion stabilizing agent, (c) emulsifying the solution of the step (b), thereby obtaining emulsion, and (d) adding retarder to the emulsion and causing suspension polymerization, thereby obtaining thermotropic liquid crystal polymer capsules.
摘要翻译：目的：提供热致液晶聚合物微胶囊，其制备方法和含有能够使液晶保持其在聚合物中的相行为的相同微胶囊的化妆品组合物。方法：该方法包括以下步骤：（a）将热致液晶和单体溶解在溶剂中，并使用超声波将引发剂加入到溶剂中;（b）将步骤（a）的溶液加入到含有分散稳定剂，（c）乳化步骤（b）的溶液，从而获得乳液，和（d）向乳液中加入缓凝剂并引起悬浮聚合，由此获得热致液晶聚合物胶囊。

6. 发明授权

KR100537952B1 중공형 소수성 고분자 마이크로캡슐 및 이의 제조방법, 및이 마이크로캡슐을 함유하는 화장료 조성물 失效
标题翻译：由疏水性聚合物制成的空心型微胶囊及其制备方法，以及含有该微胶囊的化妆品组合物
公开(公告)号：KR100537952B1
公开(公告)日：2005-12-21
申请号：KR1020010019821
申请日：2001-04-13
申请人： 주식회사 아모레퍼시픽그룹
发明人： 권순상 , 유병희 , 이종석 , 주희경 , 한상훈
IPC分类号： A61K9/48
摘要： 본 발명은 화장품에 사용되는 수용성 활성성분을 함유하는 마이크로캡슐에 있어서, 활성성분을 다량 함유하면서 그들의 안정성을 향상시키기 위하여 내부구조를 중공형으로 하고, 소수성 고분자로 제조한 중공형 소수성 고분자 마이크로캡슐 및 이의 제조방법, 및 이를 함유하는 화장료 조성물에 관한 것이다.

7. 发明授权

KR100517072B1 폴리올/고분자 마이크로캡슐 및 이를 이용한 효소 안정화방법 有权
标题翻译：多元醇/聚合物微胶囊和使用它的酶的稳定方法
公开(公告)号：KR100517072B1
公开(公告)日：2005-09-26
申请号：KR1020020073433
申请日：2002-11-25
申请人： 주식회사 아모레퍼시픽그룹
发明人： 주희경 , 김진웅 , 한상훈 , 장이섭
IPC分类号： A61K9/50
摘要： 본 발명은 효소를 폴리올계에서 근본적으로 안정화하고 이를 다시 고분자 마이크로캡슐로 궁극적으로 안정화하는 효소의 안정화 방법에 관한 것이다. 더욱 구체적으로는 효소를 저분자량 폴리올에 균일하게 분산시켜 효소를 안정화시키는 단계; 상기 안정화된 효소/폴리올을 고분자 용액에서 재분산시킨 후 유화과정을 거쳐 에멀젼을 수득하는 단계; 및 효소/폴리올/고분자 용액을 고화시켜 경질 고분자 마이크로캡슐로 회수하는 단계;를 포함한다.

8. 发明公开

KR1020020079131A 중공형 소수성 고분자 마이크로캡슐 및 이의 제조방법, 및이 마이크로캡슐을 함유하는 화장료 조성물 失效
标题翻译：疏水性中空聚合物微生物及其生产方法及含微生物的化妆品组合物
公开(公告)号：KR1020020079131A
公开(公告)日：2002-10-19
申请号：KR1020010019821
申请日：2001-04-13
申请人： 주식회사 아모레퍼시픽그룹
发明人： 권순상 , 유병희 , 이종석 , 주희경 , 한상훈
IPC分类号： A61K9/48
CPC分类号： A61K8/11 , A61K8/066 , A61K8/66 , A61K8/676 , A61K8/8152 , A61K2800/412 , A61K2800/56 , A61Q19/00
摘要： PURPOSE: A process of preparing a hollow polymer microcapsule using a biocompatible nonbiodegradable hydrophobic polymer is provided. Whereby, the microcapsule contains a large amount of water soluble active component and effectively exerts an active component function. CONSTITUTION: The hollow polymer microcapsule contains a water soluble active component, has a hollow capsule shape and comprises a hydrophobic polymer to improve the stability of the water soluble active component. The microcapsule is prepared by the process: preparing a phase 1 by adding 0.01 to 40% by weight of a water soluble active component to distilled water; preparing an oil phase by adding 0.1 to 20% by weight of a hydrophobic polymer and surfactant to distilled water; preparing a first water-in-oil emulsion by adding the phase 1 to the oil phase; preparing a phase 2; mixing the first emulsion with the phase 2; and hardening the obtained multiple emulsion.
摘要翻译：目的：提供使用生物相容性不可生物降解的疏水性聚合物制备中空聚合物微胶囊的方法。由此，微胶囊含有大量的水溶性活性成分，有效地发挥活性成分的功能。构成：中空聚合物微胶囊含有水溶性活性成分，具有中空胶囊形状，并含有疏水性聚合物，以提高水溶性活性成分的稳定性。该微胶囊通过以下方法制备：通过向蒸馏水中加入0.01至40重量％的水溶性活性组分来制备相1; 通过向蒸馏水中加入0.1〜20重量％的疏水性聚合物和表面活性剂来制备油相; 通过向油相中加入相1来制备第一种油包水乳液; 准备阶段2; 将第一乳液与相2混合; 并硬化得到的多重乳液。

9. 发明公开

KR1020040045607A 폴리올/고분자 마이크로캡슐 및 이를 이용한 효소 안정화방법 有权
标题翻译：聚合物/聚合物的微球和使用其稳定酶的方法
公开(公告)号：KR1020040045607A
公开(公告)日：2004-06-02
申请号：KR1020020073433
申请日：2002-11-25
申请人： 주식회사 아모레퍼시픽그룹
发明人： 주희경 , 김진웅 , 한상훈 , 장이섭
IPC分类号： A61K9/50
CPC分类号： A61K9/5021 , A61K9/5015 , A61K38/43
摘要： PURPOSE: Provided are a microcapsule of polyol/polymer and a method for stabilizing an enzyme using the same. Particularly, an enzyme of which stability is dramatically lowered when used in a formulation is stabilized with polyols basically and then into a microcapsule ultimately. Therefore, the enzyme is effectively stabilized. CONSTITUTION: A method for stabilizing an enzyme using a microcapsule of polyol/polymer is characterized by the steps of: dispersing an enzyme in low molecular weight of polyol evenly for stabilization; re-dispersing the stabilized enzyme/polyol in a polymeric solution, followed by emulsification to give an emulsion; and solidifying the enzyme/polyol/polymeric solution to give a hardened polymeric microcapsule.
摘要翻译：目的：提供多元醇/聚合物的微胶囊以及使用其来稳定酶的方法。特别地，当在制剂中使用时其稳定性显着降低的酶基本上用多元醇稳定，然后最终进入微胶囊。因此，酶有效稳定。构成：使用多元醇/聚合物的微胶囊稳定酶的方法的特征在于以下步骤：将酶分散在低分子量的多元醇中用于稳定化; 将稳定的酶/多元醇重新分散在聚合物溶液中，随后乳化以得到乳液; 并固化酶/多元醇/聚合物溶液以得到硬化的聚合物微胶囊。

10. 发明公开

KR1020030060017A 나노유화기술에 의해 진세노사이드 Ｆ1을 함유하는 미세 유화 입자 및 이를 사용한 피부 외용제 조성물 有权
标题翻译：通过纳米技术包含茚三酮F1的纳米颗粒和用于皮肤的外用剂组合物
公开(公告)号：KR1020030060017A
公开(公告)日：2003-07-12
申请号：KR1020020000613
申请日：2002-01-05
申请人： 주식회사 아모레퍼시픽그룹
发明人： 유병희 , 강병영 , 염명훈 , 성대석 , 주희경 , 한상훈 , 김한곤
IPC分类号： A61K8/35 , A61Q19/08 , B82Y5/00
CPC分类号： A61K8/63 , A61K8/14 , A61K8/553 , A61K8/66 , A61Q19/00 , A61Q19/08 , B82Y5/00
摘要： PURPOSE: An external agent composition for application to the skin is provided which is maximized in skin absorption by containing ginsenoside F1 as a major metabolite of Panax Ginseng prepared by a bioconversion process within nanoemulsions or liposomes using nanoemulsion techniques. Therefore, the external skin agent composition has improved transdermal absorption rate and an excellent skin aging-preventing effect such as wrinkle abatement. CONSTITUTION: An external skin agent composition contains 10¬-8 to 99.00% by weight of nanoemulsion particles having an average particle size of 30 to 500nm. The nanoemulsion particles contain 10¬-8 to 99.00% by weight of ginsenoside F1 of the formula 1 as an effective ingredient through nanoemulsion techniques, wherein the ginsenoside F1 is prepared by bioconversion of ginseng saponin and removal of sugar.
摘要翻译：目的：提供一种适用于皮肤的外用剂组合物，其通过使用纳米乳液技术将含有人参皂甙F1作为通过纳米乳剂或脂质体内的生物转化过程制备的人参皂甙的主要代谢物，使皮肤吸收最大化。因此，外用皮肤剂组合物具有改善的经皮吸收速率和优异的防止皮肤老化的效果，例如皱纹消除。构成：外用皮肤剂组合物含有10〜8〜99.00重量％的平均粒径为30〜500nm的纳米乳剂颗粒。纳米乳剂颗粒含有10〜8〜99.00重量％的式1的人参皂苷F1作为有效成分，通过纳米乳液技术，其中人参皂苷F1是通过人参皂角苷的生物转化和除去糖来制备的。

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