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    • 1. 发明公开
    • 하이드록시신남산 유도체 또는 이를 포함하는 당귀추출물을 함유하는 치매 예방 및 치료용 조성물
    • 含有羟化酸性衍生物或含有其的氨基酸衍生物衍生物的组合物预防和处理组合物
    • KR1020000071673A
    • 2000-11-25
    • KR1020000019330
    • 2000-04-12
    • 주식회사 싸이제닉주식회사 바이오시너젠
    • 김영희송동근서홍원허성오
    • A61K36/232A61P25/28
    • A61K31/216A61K31/192A61K31/235A61K36/232
    • PURPOSE: A composition containing hydroxycinnamic acid derivatives or Angelicae gigantis Radix extract comprising same is provided, which is used for preventing and treating the dementia, and which can be prepared in the form of pharmaceutical compositions or food. CONSTITUTION: A process for the preparation of Angelica gigantis Radix extract comprises of: adding 80% methanol to Angelica gigantis Radix(Angelica gigas Nakai, Angelica acutiloba Kitagawa, Angelica sinensis Diels), and extracting at 40°C for 2hrs in water bath(repeating this step for 2times); collecting the extracts, evaporating moisture from methanol using a decompressed-circulating refrigerating pipe, and drying using a decompressed-dryer to get Angelica gigantis Radix extract. The Angelica gigantis Radix extract contains decursinol and ferulic acid(a kind of hydroxycinnamic acid derivatives) in the content of 0.5wt.% and 0.07wt.% each. A dementia-preventing and treating composition containing hydroxycinnamic acid derivatives can be prepared by mixing Angelica gigantis Radix extract, milk calcium, fine-crystallized cellulose, isoflavone, ginkgo leaves extract, vitamin B1, B2, D3, and filling up to a gelatin capsule.
    • 目的:提供含有羟基肉桂酸衍生物或包含其的当归提取物的组合物,其用于预防和治疗痴呆,并且其可以以药物组合物或食品的形式制备。 构成:制备当归提取物的方法包括:向当归加入80%的甲醇(当归,中药,当归,川Di),并在40℃下在水浴中提取2小时(重复 这一步为2次); 收集提取物,使用减压循环冷冻管从甲醇蒸发水分,并使用减压干燥器进行干燥以得到当归甘草提取物。 当归提取物含有0.5%(重量)和0.07%(重量)%的前胡萝卜醇和阿魏酸(一种羟基肉桂酸衍生物)。 含有羟基肉桂酸衍生物的痴呆症预防和治疗组合物可以通过混合当归七宝提取物,乳钙,细结晶纤维素,异黄酮,银杏叶提取物,维生素B1,B2,D3,并填充到明胶胶囊中来制备。
    • 3. 发明公开
    • 데커시놀을 포함하는 패혈성 쇼크 예방 및 치료용 조성물
    • 用于预防和治疗含有去甲肾上腺素的崩溃组合物
    • KR1020020029462A
    • 2002-04-19
    • KR1020000060196
    • 2000-10-13
    • 주식회사 싸이제닉주식회사 바이오시너젠
    • 김영희송동근서홍원허성오
    • A61K31/366
    • PURPOSE: A pharmaceutical composition obtained from extraction, separation and purification of Angelica gigas and containing decursinol and a pharmaceutically acceptable carrier is provided which is effective for the prevention and treatment of septic shock. CONSTITUTION: This composition contains decursinol; (S)-isomers 7,8-dihydro-7-hydroxy-8,8-dimethyl-2H,6H-benzo£1,2-b:5,4-b'|dipyran-2-one as an effective component. For an example, 1kg Angelica gigas is added with 2L methanol and extracted in an aqueous solution at 40deg.C for 2 hr. The above procedure is repeated two times and the extract is subjected to evaporation using a vacuum reflux condensing tube to remove moisture from methanol and drying with a vacuum drier to produce 290g extract.
    • 目的:提供从提取,分离和纯化当归和含有前胡萝卜醇和药学上可接受的载体获得的药物组合物,其有效预防和治疗败血性休克。 构成:该组合物含有十二烷醇; (S) - 异构体7,8-二氢-7-羟基-8,8-二甲基-2H,6H-苯并1,2-b:5,4-b'|二吡喃-2-酮作为有效成分。 例如,将1kg Angelica gigas加入2L甲醇,并在40℃的水溶液中萃取2小时。 将上述步骤重复两次,并使用真空回流冷凝管将提取物蒸发除去甲醇中的水分并用真空干燥器干燥,得到290g提取物。
    • 6. 发明公开
    • 당뇨병 예방 및 치료용 약제학적 조성물 및 기능성 식품
    • 用于预防和治疗糖尿病的药物组合物和功能性食品,包含非法利多卡耳酵母(VICUM VUUM HOOK)或氟利昂
    • KR1020030019049A
    • 2003-03-06
    • KR1020020001508
    • 2002-01-10
    • 주식회사 바이오시너젠
    • 김영희송동근서홍원허성오
    • A61K36/235A61P3/10
    • PURPOSE: A pharmaceutical composition and a functional food for prevention and treatment of diabetes mellitus, containing an extract of Illicium verum Hook or Foeniculum vulgare Mill are provided, thereby effectively preventing and treating diabetes mellitus. CONSTITUTION: The pharmaceutical composition for prevention and treatment of diabetes mellitus contains the extract of Illicium verum Hook or Foeniculum vulgare, wherein the extract of Illicium verum Hook or Foeniculum vulgare is extracted with water, methanol, ethanol, acetone, chloroform, methylene chloride or the mixture thereof as an extraction solvent; and the extract of Illicium verum Hook or Foeniculum vulgare contains trans-anethole. The functional food contains the extract of Illicium verum Hook or Foeniculum vulgare, wherein the food includes drinks, chewing gum, tea products, vitamin complexes, health foods, processed foods, and powdered foods.
    • 目的:提供一种药物组合物和用于预防和治疗糖尿病的药物组合物和功能性食品,其含有ium藜提取物或Foeniculum vulgare Mill,从而有效预防和治疗糖尿病。 构成:用于预防和治疗糖尿病的药物组合物含有ium藜提取物或Foeniculum vulgare,其中ium藜提取物或Foeniculum vulgare用水,甲醇,乙醇,丙酮,氯仿,二氯甲烷或 其混合物作为提取溶剂; ium藜提取物或茯苓提取物含有异烟孔。 功能性食品含有藜芦提取物,其中食物包括饮料,口香糖,茶产品,维生素复合物,保健食品,加工食品和粉末食品。
    • 7. 发明公开
    • 라이소포스파티딘산을 포함하는 뇌졸중 예방 및 치료용조성물
    • 用于预防和治疗含有肉豆蔻酸的谷氨酸复合物的组合物
    • KR1020030006576A
    • 2003-01-23
    • KR1020010042395
    • 2001-07-13
    • 주식회사 바이오시너젠
    • 송동근허성오조정숙서홍원김영희
    • A61K31/6615
    • PURPOSE: A composition containing lysophosphatidic acid and a pharmaceutically acceptable salt as an effective ingredient is provided which can be effectively used for prevention and treatment of cerebral apoplexy by remarkably lowering brain infarction by brain ischemia. CONSTITUTION: The composition contains lysophosphatidic acid of formula 1 and a pharmaceutically acceptable salt, wherein R1 is substituted or non-substituted linear or branched C4-30 alkyl. The pharmaceutically acceptable salt of lysophosphatidic acid is, for example, an inorganic salt such as a sodium salt, magnesium salt and calcium salt, and organic salt such as ammonium salt, lysin, ethanolamine, N,N'-dibenzylethylene amine, angelic acid, but it is not limited within them.
    • 目的:提供含有溶血磷脂酸和药学上可接受的盐作为有效成分的组合物,其可以通过显着降低脑缺血的脑梗死而有效地用于预防和治疗脑中风。 构成:组合物含有式1的溶血磷脂酸及其药学上可接受的盐,其中R 1是取代或未取代的直链或支链C 4-30烷基。 溶血磷脂酸的药学上可接受的盐是例如无机盐如钠盐,镁盐和钙盐,以及有机盐如铵盐,赖氨酸,乙醇胺,N,N'-二苯乙烯胺,当归酸, 但不限于此。