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1. 发明公开

KR1020000071673A 하이드록시신남산 유도체 또는 이를 포함하는 당귀추출물을 함유하는 치매 예방 및 치료용 조성물 失效
标题翻译：含有羟化酸性衍生物或含有其的氨基酸衍生物衍生物的组合物预防和处理组合物
公开(公告)号：KR1020000071673A
公开(公告)日：2000-11-25
申请号：KR1020000019330
申请日：2000-04-12
申请人： 주식회사 싸이제닉 , 주식회사 바이오시너젠
发明人： 김영희 , 송동근 , 서홍원 , 허성오
IPC分类号： A61K36/232 , A61P25/28
CPC分类号： A61K31/216 , A61K31/192 , A61K31/235 , A61K36/232
摘要： PURPOSE: A composition containing hydroxycinnamic acid derivatives or Angelicae gigantis Radix extract comprising same is provided, which is used for preventing and treating the dementia, and which can be prepared in the form of pharmaceutical compositions or food. CONSTITUTION: A process for the preparation of Angelica gigantis Radix extract comprises of: adding 80% methanol to Angelica gigantis Radix(Angelica gigas Nakai, Angelica acutiloba Kitagawa, Angelica sinensis Diels), and extracting at 40°C for 2hrs in water bath(repeating this step for 2times); collecting the extracts, evaporating moisture from methanol using a decompressed-circulating refrigerating pipe, and drying using a decompressed-dryer to get Angelica gigantis Radix extract. The Angelica gigantis Radix extract contains decursinol and ferulic acid(a kind of hydroxycinnamic acid derivatives) in the content of 0.5wt.% and 0.07wt.% each. A dementia-preventing and treating composition containing hydroxycinnamic acid derivatives can be prepared by mixing Angelica gigantis Radix extract, milk calcium, fine-crystallized cellulose, isoflavone, ginkgo leaves extract, vitamin B1, B2, D3, and filling up to a gelatin capsule.
摘要翻译：目的：提供含有羟基肉桂酸衍生物或包含其的当归提取物的组合物，其用于预防和治疗痴呆，并且其可以以药物组合物或食品的形式制备。构成：制备当归提取物的方法包括：向当归加入80％的甲醇（当归，中药，当归，川Di），并在40℃下在水浴中提取2小时（重复这一步为2次）; 收集提取物，使用减压循环冷冻管从甲醇蒸发水分，并使用减压干燥器进行干燥以得到当归甘草提取物。当归提取物含有0.5％（重量）和0.07％（重量）％的前胡萝卜醇和阿魏酸（一种羟基肉桂酸衍生物）。含有羟基肉桂酸衍生物的痴呆症预防和治疗组合物可以通过混合当归七宝提取物，乳钙，细结晶纤维素，异黄酮，银杏叶提取物，维生素B1，B2，D3，并填充到明胶胶囊中来制备。

2. 发明授权

KR100336182B1 하이드록시신남산 유도체 또는 이를 포함하는 당귀추출물을 함유하는 치매 예방 및 치료용 조성물 失效
标题翻译：用于预防和治疗含有羟基肉桂酸衍生物或含有该衍生物的当归鬼臼膏提取物的组合物
公开(公告)号：KR100336182B1
公开(公告)日：2002-05-10
申请号：KR1020000019330
申请日：2000-04-12
申请人： 주식회사 싸이제닉 , 주식회사 바이오시너젠
发明人： 김영희 , 송동근 , 서홍원 , 허성오
IPC分类号： A61K36/232 , A61P25/28
摘要： 본 발명은 유효성분으로서 하기 화학식 1의 하이드록시신남산(hydroxycinnamic acid) 유도체, 데커시놀, 이들의 약학적으로 허용되는 염 또는 이들을 포함하는 당귀 추출물을 함유하는 치매 예방 및 치료용 약학 조성물 및 식품에 관한 것으로, 본 발명의 약학 조성물 및 식품은 치매의 예방 및 치료에 유용하게 사용될 수 있다.

상기 식에서,
R
1 은 H 또는 CH
3 이고,
R
2 는 -CH=CHCOOH 또는

3. 发明公开

KR1020020029462A 데커시놀을 포함하는 패혈성 쇼크 예방 및 치료용 조성물 无效
标题翻译：用于预防和治疗含有去甲肾上腺素的崩溃组合物
公开(公告)号：KR1020020029462A
公开(公告)日：2002-04-19
申请号：KR1020000060196
申请日：2000-10-13
申请人： 주식회사 싸이제닉 , 주식회사 바이오시너젠
发明人： 김영희 , 송동근 , 서홍원 , 허성오
IPC分类号： A61K31/366
摘要： PURPOSE: A pharmaceutical composition obtained from extraction, separation and purification of Angelica gigas and containing decursinol and a pharmaceutically acceptable carrier is provided which is effective for the prevention and treatment of septic shock. CONSTITUTION: This composition contains decursinol; (S)-isomers 7,8-dihydro-7-hydroxy-8,8-dimethyl-2H,6H-benzo£1,2-b:5,4-b'|dipyran-2-one as an effective component. For an example, 1kg Angelica gigas is added with 2L methanol and extracted in an aqueous solution at 40deg.C for 2 hr. The above procedure is repeated two times and the extract is subjected to evaporation using a vacuum reflux condensing tube to remove moisture from methanol and drying with a vacuum drier to produce 290g extract.
摘要翻译：目的：提供从提取，分离和纯化当归和含有前胡萝卜醇和药学上可接受的载体获得的药物组合物，其有效预防和治疗败血性休克。构成：该组合物含有十二烷醇; （S） - 异构体7,8-二氢-7-羟基-8,8-二甲基-2H，6H-苯并1,2-b：5,4-b'|二吡喃-2-酮作为有效成分。例如，将1kg Angelica gigas加入2L甲醇，并在40℃的水溶液中萃取2小时。将上述步骤重复两次，并使用真空回流冷凝管将提取物蒸发除去甲醇中的水分并用真空干燥器干燥，得到290g提取物。

4. 发明公开

KR1020040017613A 라이소포스파티딜콜린 또는 그 유사체를 포함하는 선천성면역 증강 조성물 有权
标题翻译：用于改善包含赖氨酸衍生物及其衍生物的无效免疫的组合物
公开(公告)号：KR1020040017613A
公开(公告)日：2004-02-27
申请号：KR1020020049766
申请日：2002-08-22
申请人： 주식회사 바이오시너젠
发明人： 김영희 , 송동근 , 서홍원 , 허성오
IPC分类号： A61K31/685
CPC分类号： Y02A50/40 , Y02A50/401
摘要： PURPOSE: Provided is a pharmaceutical composition for excellently improving innate immunity comprising lysophosphatidylcholine and its derivatives as an active ingredient. CONSTITUTION: A composition for improving innate immunity is characterized by comprising lysophosphatidylcholine represented by the formula(1) and its derivatives. In the formula, R1 is C4-30 alkyl or C4-30 alkenyl having at least one of double bond.
摘要翻译：目的：提供一种药物组合物，用于显着改善包含溶血磷脂酰胆碱及其衍生物作为活性成分的先天免疫力。构成：用于改善先天免疫的组合物的特征在于包含由式（1）表示的溶血磷脂酰胆碱及其衍生物。在该式中，R 1为具有至少一个双键的C 4-30烷基或C 4-30链烯基。

5. 发明授权

KR100842160B1 라이소포스파티딜콜린 또는 그 유사체를 포함하는 패혈증예방 및 치료용 조성물 有权
标题翻译：用于预防和治疗包含LOSOPHOSPHATIDYLCHOLINE或其衍生物的食物的组合物
公开(公告)号：KR100842160B1
公开(公告)日：2008-06-27
申请号：KR1020020064308
申请日：2002-10-21
申请人： 주식회사 바이오시너젠
发明人： 김영희 , 송동근 , 서홍원 , 허성오
IPC分类号： A61K31/661
CPC分类号： Y02A50/40 , Y02A50/401
摘要： 본 발명은 패혈증 예방 및 치료 효과가 우수한 약제학적 조성물에 관한 것으로, 유효성분으로서 라이소포스파티딜콜린 및 그 유사체를 포함하는 것을 특징으로 한다.
라이소포스파티딜콜린

6. 发明公开

KR1020030019049A 당뇨병 예방 및 치료용 약제학적 조성물 및 기능성 식품 无效
标题翻译：用于预防和治疗糖尿病的药物组合物和功能性食品，包含非法利多卡耳酵母（VICUM VUUM HOOK）或氟利昂
公开(公告)号：KR1020030019049A
公开(公告)日：2003-03-06
申请号：KR1020020001508
申请日：2002-01-10
申请人： 주식회사 바이오시너젠
发明人： 김영희 , 송동근 , 서홍원 , 허성오
IPC分类号： A61K36/235 , A61P3/10
摘要： PURPOSE: A pharmaceutical composition and a functional food for prevention and treatment of diabetes mellitus, containing an extract of Illicium verum Hook or Foeniculum vulgare Mill are provided, thereby effectively preventing and treating diabetes mellitus. CONSTITUTION: The pharmaceutical composition for prevention and treatment of diabetes mellitus contains the extract of Illicium verum Hook or Foeniculum vulgare, wherein the extract of Illicium verum Hook or Foeniculum vulgare is extracted with water, methanol, ethanol, acetone, chloroform, methylene chloride or the mixture thereof as an extraction solvent; and the extract of Illicium verum Hook or Foeniculum vulgare contains trans-anethole. The functional food contains the extract of Illicium verum Hook or Foeniculum vulgare, wherein the food includes drinks, chewing gum, tea products, vitamin complexes, health foods, processed foods, and powdered foods.
摘要翻译：目的：提供一种药物组合物和用于预防和治疗糖尿病的药物组合物和功能性食品，其含有ium藜提取物或Foeniculum vulgare Mill，从而有效预防和治疗糖尿病。构成：用于预防和治疗糖尿病的药物组合物含有ium藜提取物或Foeniculum vulgare，其中ium藜提取物或Foeniculum vulgare用水，甲醇，乙醇，丙酮，氯仿，二氯甲烷或其混合物作为提取溶剂; ium藜提取物或茯苓提取物含有异烟孔。功能性食品含有藜芦提取物，其中食物包括饮料，口香糖，茶产品，维生素复合物，保健食品，加工食品和粉末食品。

7. 发明公开

KR1020030006576A 라이소포스파티딘산을 포함하는 뇌졸중 예방 및 치료용조성물 无效
标题翻译：用于预防和治疗含有肉豆蔻酸的谷氨酸复合物的组合物
公开(公告)号：KR1020030006576A
公开(公告)日：2003-01-23
申请号：KR1020010042395
申请日：2001-07-13
申请人： 주식회사 바이오시너젠
发明人： 송동근 , 허성오 , 조정숙 , 서홍원 , 김영희
IPC分类号： A61K31/6615
摘要： PURPOSE: A composition containing lysophosphatidic acid and a pharmaceutically acceptable salt as an effective ingredient is provided which can be effectively used for prevention and treatment of cerebral apoplexy by remarkably lowering brain infarction by brain ischemia. CONSTITUTION: The composition contains lysophosphatidic acid of formula 1 and a pharmaceutically acceptable salt, wherein R1 is substituted or non-substituted linear or branched C4-30 alkyl. The pharmaceutically acceptable salt of lysophosphatidic acid is, for example, an inorganic salt such as a sodium salt, magnesium salt and calcium salt, and organic salt such as ammonium salt, lysin, ethanolamine, N,N'-dibenzylethylene amine, angelic acid, but it is not limited within them.
摘要翻译：目的：提供含有溶血磷脂酸和药学上可接受的盐作为有效成分的组合物，其可以通过显着降低脑缺血的脑梗死而有效地用于预防和治疗脑中风。构成：组合物含有式1的溶血磷脂酸及其药学上可接受的盐，其中R 1是取代或未取代的直链或支链C 4-30烷基。溶血磷脂酸的药学上可接受的盐是例如无机盐如钠盐，镁盐和钙盐，以及有机盐如铵盐，赖氨酸，乙醇胺，N，N'-二苯乙烯胺，当归酸，但不限于此。

8. 发明授权

KR100842159B1 라이소포스파티딜콜린 또는 그 유사체를 포함하는 급성호흡곤란 증후군 및 다발성 장기부전의 예방 및 치료용조성물 有权
标题翻译：用于预防和治疗急性呼吸系统综合征的组合物和包含赖氨酸衍生物或其衍生物的多种器官功能障碍综合征
公开(公告)号：KR100842159B1
公开(公告)日：2008-06-27
申请号：KR1020020016029
申请日：2002-03-25
申请人： 주식회사 바이오시너젠
发明人： 김영희 , 서홍원 , 송동근 , 허성오
IPC分类号： A61K31/661
CPC分类号： Y02A50/40 , Y02A50/401
摘要： 본 발명은 급성 호흡곤란 증후군 및 다발성 장기부전의 예방 및 치료 효과가 우수한 약제학적 조성물에 관한 것으로, 유효성분으로서 라이소포스파티딜콜린 및 그 유사체를 포함하는 것을 특징으로 한다.
급성 호흡곤란 증후군, 다발성 장기부전, 라이소포스파티딜콜린

9. 发明公开

KR1020030094515A 라이소포스파티딜콜린 또는 그 유사체를 포함하는 급성호흡곤란 증후군 및 다발성 장기부전의 예방 및 치료용조성물 有权
标题翻译：用于预防和治疗急性呼吸系统综合症和多种器官功能障碍综合征LOSOPHOSPHATIDCHOLINE，含有LOSOPHOSPHATIDYLCHOLINE或其模拟物的组合物
公开(公告)号：KR1020030094515A
公开(公告)日：2003-12-18
申请号：KR1020020016029
申请日：2002-03-25
申请人： 주식회사 바이오시너젠
发明人： 김영희 , 서홍원 , 송동근 , 허성오
IPC分类号： A61K31/661
CPC分类号： Y02A50/40 , Y02A50/401
摘要： PURPOSE: A pharmaceutical composition containing lysophosphatidylcholine and analogs thereof as an effective ingredient is provided which has an excellent therapeutic effect on acute respiratory distress syndrome multiple organ dysfunction syndrome and can remarkably decrease the mortality. CONSTITUTION: A composition contains lysophosphatidylcholine and ether analogs thereof represented by the formula 1. In formula, R1 is C4-30 alkyl, or C4-30 alkenyl having one or more double bonds. The ether analogs of lysophosphatidylcholine are one or more selected from L-α-lysophosphatidylcholine, γ-o-Alk-1-enyl, L-α -lysophosphatidylcholine, γ-o-alkyl, DL-α-lysophosphatidylcholine, γ-o-hexadecyl, L- α-lysophosphatidylcholine and γ-o-hexadecyl.
摘要翻译：目的：提供含有溶血磷脂酰胆碱及其类似物作为有效成分的药物组合物，对急性呼吸窘迫综合征多器官功能障碍综合征具有优异的治疗作用，可显着降低死亡率。组成：组合物含有由式1表示的溶血磷脂酰胆碱及其醚类似物。在式中，R 1为C 4-30烷基或具有一个或多个双键的C 4-30烯基。溶血磷脂酰胆碱的醚类似物是选自L-α-溶血磷脂酰胆碱，γ-邻 - 烯-1-烯基，L-α-异磷脂酰胆碱，γ-邻 - 烷基，DL-α-溶血磷脂酰胆碱，γ-邻 - 十六烷基，L-α-溶血磷脂酰胆碱和γ-邻十六烷基。

10. 发明授权

KR100397950B1 데커시놀 또는 이의 유도체를 포함하는 진통제 조성물 失效
标题翻译： 데커시놀또는이의유도체를포함하는진통제조성물
公开(公告)号：KR100397950B1
公开(公告)日：2003-09-19
申请号：KR1020010000055
申请日：2001-01-02
申请人： 주식회사 싸이제닉 , 주식회사 겟웰바이오
发明人： 김영희 , 송동근 , 서홍원 , 허성오
IPC分类号： A61K31/35
CPC分类号： A61K31/366
摘要： A composition for preventing or treating dementia comprising a hydroxycinnamic acid derivative of formula (I), decursinol, a pharmaceutically acceptable salt thereof or an extract of a plant of genus Angelicae containing same, wherein, R1 is H or CH3, R2 is -CH=CHCOOH or formula (a).
摘要翻译：一种用于预防或治疗痴呆的组合物，其包含式（I）的羟基肉桂酸衍生物，小檗醇，其药学上可接受的盐或当归的植物提取物，其中R 1是H或CH 3，R 2是-CH = CHCOOH或式（a）。

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