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2. 发明公开

KR1020130001986A 설글리코타이드의 제조방법 有权
标题翻译：制备磺酰胆碱的方法
公开(公告)号：KR1020130001986A
公开(公告)日：2013-01-07
申请号：KR1020110062948
申请日：2011-06-28
申请人： 주식회사 성운바이오 , (주) 성운파마코피아
发明人： 정준기 , 장형욱 , 정인화 , 신현만 , 선재만 , 이인규 , 김재범 , 유철배
IPC分类号： C12P21/06 , C07K1/34 , C07K14/47 , C12N9/50
CPC分类号： C12P21/06 , C07K1/34 , C07K14/47
摘要： PURPOSE: A method for preparing novel sulglycotide is provided to shorten preparation process and to improve preparation yield and product quality. CONSTITUTION: A method for preparing sulglycotide comprises: a step of hydrolyzing pig duodenum at 60-100 deg. C and pH 7.5-9.5 for 10-20 minutes; a step of removing floating matters generated after the hydrolysis by centrifugal dehydration or using drum filtration equipment; a step of performing ultrafiltation of a reaction solution in which the floating matters are removed; a step of adding protease to the filtered liquid; a step of performing ultrafiltration of the enzyme-reacted liquid and preparing glycopeptide; and a step of adding glycopeptides into a reaction solution containing organic bases and sulfur compounds; and a step of performing sulfur reaction and ultrafiltration and preparing sulglycotide. The protease includes papain, bromelain, protease, chymotrypsin, or trypsin.
摘要翻译：目的：制备新型磺糖苷的方法，缩短制备工艺，提高制剂产量和产品质量。构成：制备苏糖苷的方法包括：在60-100℃水解十二指肠的步骤。 C和pH 7.5-9.5 10-20分钟; 通过离心脱水或使用鼓过滤设备去除水解后产生的漂浮物的步骤; 进行漂浮物除去的反应液的超滤的工序; 向滤液中加入蛋白酶的步骤; 进行酶反应液体的超滤并制备糖肽的步骤; 以及将糖肽加入到含有机碱和硫化合物的反应溶液中的步骤; 并进行硫反应和超滤并制备苏糖苷的步骤。蛋白酶包括木瓜蛋白酶，菠萝蛋白酶，蛋白酶，糜蛋白酶或胰蛋白酶。

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