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1. 发明授权

KR101000945B1 매트릭스형 경피투여제 및 이의 제조방법 有权
标题翻译：基质型透皮药物递送系统及其制备方法
公开(公告)号：KR101000945B1
公开(公告)日：2010-12-13
申请号：KR1020080053294
申请日：2008-06-05
申请人： 주식회사 삼양홀딩스
发明人： 김동원 , 송진덕
IPC分类号： A61K9/70 , A61K31/16 , A61K47/30
CPC分类号： A61K9/7061
摘要： 캡사이신 또는 캡사이신 유사체를 활성 성분으로 포함하여 신경병증 치료, 진통 또는 소염을 위해 사용되는 매트릭스형 경피투여제 및 이의 제조방법이 제공된다.
상기 매트릭스형 경피투여제는, 약물 보호층; 캡사이신 또는 캡사이신 유사체의 0.1-25중량%와, 비수용성 아크릴계 고분자를 포함한 점착제의 40-95중량%와, 600달톤 이하의 분자량을 가진 알코올의 1-30중량%와, 비이온성 계면활성제의 0.1-20중량%와, 친수성 고분자를 포함한 용해보조제의 0.1-20중량%를 포함하고, 상기 약물 보호층 상에 형성되는 매트릭스층; 및 상기 매트릭스층 상에 형성되는 박리층을 포함하고, 신경병증 치료, 진통 또는 소염을 위해 사용되는 것이다.
캡사이신, 매트릭스형 경피투여제, 흡수촉진제, 용해보조제, 점착층

2. 发明公开

KR1020080108050A 매트릭스형 경피투여제 및 이의 제조방법 有权
标题翻译： MATRIX型转膜药物递送系统及其制备方法
公开(公告)号：KR1020080108050A
公开(公告)日：2008-12-11
申请号：KR1020080053294
申请日：2008-06-05
申请人： 주식회사 삼양홀딩스
发明人： 김동원 , 송진덕
IPC分类号： A61K9/70 , A61K31/16 , A61K47/30
CPC分类号： A61K9/7061
摘要： A matrix-type transdermal drug delivery system, and a method for preparing the matrix-type transdermal drug delivery system are provided to improve the skin penetration of capsaicin or its analogues and to increase the duration time of active ingredients. A matrix-type transdermal drug delivery system comprises a drug protection layer(1); matrix layers(2a, 2b, 2a'') which comprise 0.1-25 wt% of capsaicin or its analogues, 40-95 wt% of an adhesive comprising a water-insoluble acrylic polymer, 1-30 wt% of an alcohol having a molecular weight of 600 Dalton or more, 0.1-20 wt% of a nonionic surfactant, and 0.1-20 wt% of a dissolution aid comprising a hydrophilic polymer, and are formed on the drug protection layer; and a release layer(3) which is formed on the matrix layer.
摘要翻译：提供基质型透皮药物递送系统和制备基质型透皮药物递送系统的方法以改善辣椒素或其类似物的皮肤渗透并增加活性成分的持续时间。基质型透皮药物递送系统包括药物保护层（1）; 包含0.1-25重量％辣椒素或其类似物的基质层（2a，2b，2a“），40-95重量％的包含水不溶性丙烯酸聚合物的粘合剂，1-30重量％的具有分子量为600道尔顿以上，0.1-20重量％的非离子表面活性剂和0.1-20重量％的包含亲水性聚合物的溶解助剂，并形成在药物保护层上; 和形成在基体层上的剥离层（3）。

3. 发明授权

KR100406722B1 수분흡수능이 우수한 매트릭스형 경피투여제 有权
标题翻译： 수분흡수능이우수한매트릭스형경피투제
公开(公告)号：KR100406722B1
公开(公告)日：2003-11-21
申请号：KR1020010068525
申请日：2001-11-05
申请人： 주식회사 삼양홀딩스
发明人： 송진덕 , 김동원
IPC分类号： A61K9/70
CPC分类号： A61K9/7053 , A61K9/7061 , A61K31/196 , A61K47/02 , A61K47/32
摘要： An active agent containing adhesive composition suitable for transdermal drug delivery having excellent water absorbability which comprises an effective amount of an active agent, an acrylate adhesive, a polyvinylpyrrolidone having a molecular weight of 1,000,000-5,000,000; a polyvinylpyrrolidone having a molecular weight of 2,000-50,000; a non-ionic surfactant; a terpene; and a dissolution assistant.
摘要翻译：含有有效量的活性剂，丙烯酸酯粘合剂，分子量为1,000,000-5,000,000的聚乙烯吡咯烷酮的含有活性剂的粘合剂组合物适用于透皮给药，具有极好的吸水性; 分子量为2,000-50,000的聚乙烯吡咯烷酮; 非离子表面活性剂; 萜烯; 和解散助理。

4. 发明公开

KR1020020035451A 수분흡수능이 우수한 매트릭스형 경피투여제 有权
标题翻译：具有改进的吸水性能的矩阵式，超导药物递送系统
公开(公告)号：KR1020020035451A
公开(公告)日：2002-05-11
申请号：KR1020010068525
申请日：2001-11-05
申请人： 주식회사 삼양홀딩스
发明人： 송진덕 , 김동원
IPC分类号： A61K9/70
CPC分类号： A61K9/7053 , A61K9/7061 , A61K31/196 , A61K47/02 , A61K47/32
摘要： PURPOSE: A matrix type, transdermal drug delivery system having improved water-absorbability is provided, which system absorbs sweat well and is easily removed from the skin. CONSTITUTION: The matrix type, transdermal drug delivery system having improved water-absorbability comprises a backing layer(1) protecting a drug, a matrix layer(2) containing an effective drug and a release liner film(3) to be removed before applying the system to the skin, in which the matrix layer(2) contains 1 to 25 wt.% of effective drugs, 40 to 95 wt.% of acryl adhesive, 1 to 7 wt.% of polyvinylpyrrolidone having a molecular weight of 1 million to 500 million, 1 to 13 wt.% of polyvinylpyrrolidone having a molecular weight of 2,000 to 50,000, 0.1 to 25 wt.% of nonionic surfactant as an absorption promoting agent, 0.1 to 10 wt.% of terepene diluent and 0.1 to 10 wt.% of melting-assistant solvent, and further contains 0.5 to 5 wt.% of colloidal silica; and the effective drug is diclofenac diethylammonium.
摘要翻译：目的：提供具有改善的吸水性的基质型透皮药物递送系统，该系统很好地吸收汗液，容易从皮肤上去除。构成：具有改善的吸水性的基质型透皮药物递送系统包括保护药物的背衬层（1），含有有效药物的基质层（2）和待使用的剥离衬垫膜（3）系统，其中基质层（2）含有1至25重量％的有效药物，40至95重量％的丙烯酸粘合剂，1至7重量％的分子量为100万的聚乙烯吡咯烷酮 5重量％，1〜13重量％的分子量为2,000〜50,000的聚乙烯吡咯烷酮，0.1〜25重量％的作为吸收促进剂的非离子表面活性剂，0.1〜10重量％的泼尼松稀释剂和0.1〜10重量％％的熔融助溶剂，还含有0.5〜5重量％的胶体二氧化硅; 有效药物为双氯芬酸二乙基铵。

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