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1. 发明授权

KR100461859B1 옥시라세탐의 제조방법 失效
标题翻译： 옥시라세탐의제조방법
公开(公告)号：KR100461859B1
公开(公告)日：2004-12-14
申请号：KR1020020022150
申请日：2002-04-23
申请人： 주식회사 바이넥스 , 이백천
发明人： 박민수 , 강재선 , 안병근 , 김원석 , 박유수 , 손철훈
IPC分类号： C07D207/27
摘要： PURPOSE: A manufacturing method of oxiracetam is provided, thereby manufacturing oxiracetam at room temperature under mild condition in higher yield. CONSTITUTION: A manufacturing method of oxiracetam comprises the steps of: condensation of vinyl acetyl chloride of the formula 1 with glycine ethyl ester to prepare 3-butenoylamino-acetic ethyl ester of the formula 2: epoxylation of 3-butenoylamino-acetic ethyl ester of the formula 2 using HO-X in which X is halogen or CH2Cl2 to prepare an epoxy compound of the formula 3 as an intermediate; adding a base to the epoxy compound of the formula 3 for cyclization of the epoxy compound to form 5-membered ring of the formula 4; and dissolving the 5-membered ring of the formula 4 in ammonia water to prepare oxiracetam of the formula 5.
摘要翻译：目的：提供一种奥拉西坦的制造方法，由此在室温下在温和条件下以较高的收率制造奥拉西坦。构成：奥拉西坦的制造方法包括以下步骤：将式1的乙烯基乙酰氯与甘氨酸乙酯缩合制备式2的3-丁烯酰氨基 - 乙酸乙酯：将式2的3-丁烯酰氨基 - 乙酸乙酯环氧化使用其中X是卤素或CH 2 Cl 2的HO-X来制备式3的环氧化合物作为中间体; 向式3的环氧化合物中加入碱以使环氧化合物环化形成式4的5元环; 并将式4的5元环溶于氨水中以制备式5的奥拉西坦。

2. 发明公开

KR1020030083466A 옥시라세탐의 제조방법 失效
标题翻译： OXIRACETAM的制备方法
公开(公告)号：KR1020030083466A
公开(公告)日：2003-10-30
申请号：KR1020020022150
申请日：2002-04-23
申请人： 주식회사 바이넥스 , 이백천
发明人： 박민수 , 강재선 , 안병근 , 김원석 , 박유수 , 손철훈
IPC分类号： C07D207/27
摘要： PURPOSE: A manufacturing method of oxiracetam is provided, thereby manufacturing oxiracetam at room temperature under mild condition in higher yield. CONSTITUTION: A manufacturing method of oxiracetam comprises the steps of: condensation of vinyl acetyl chloride of the formula 1 with glycine ethyl ester to prepare 3-butenoylamino-acetic ethyl ester of the formula 2: epoxylation of 3-butenoylamino-acetic ethyl ester of the formula 2 using HO-X in which X is halogen or CH2Cl2 to prepare an epoxy compound of the formula 3 as an intermediate; adding a base to the epoxy compound of the formula 3 for cyclization of the epoxy compound to form 5-membered ring of the formula 4; and dissolving the 5-membered ring of the formula 4 in ammonia water to prepare oxiracetam of the formula 5.
摘要翻译：目的：提供奥拉西坦的制造方法，由此在温和条件下以较高的产率在室温下制造奥拉西坦。构成：奥拉西坦的制备方法包括以下步骤：将式1的乙烯基乙酰氯与甘氨酸乙酯的缩合制备式2的3-丁烯酰氨基 - 乙酸乙酯：3-丁烯酰氨基 - 乙酸乙酯的环氧化式2使用其中X为卤素或CH 2 Cl 2的HO-X，以制备作为中间体的式3的环氧化合物; 向式3的环氧化合物加入碱，使环氧化合物环化形成式4的5元环; 并将式4的5元环溶解在氨水中以制备式5的奥拉西坦。

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