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1. 发明公开

KR1020140088401A 초식성 해양무척추동물 내장 유래 조효소를 이용하는 난분해성 해조류의 당화 방법 无效
标题翻译：使用海洋生物处理的不可降解的海藻衍生物的酶解方法
公开(公告)号：KR1020140088401A
公开(公告)日：2014-07-10
申请号：KR1020130000235
申请日：2013-01-02
申请人： 조선대학교산학협력단
发明人： 정원교 , 천충길
IPC分类号： C12P19/00 , C07H1/08
CPC分类号： C12P19/02
摘要： The present invention relates to a glycosylation method of a non-degradable substance of seaweed using a marine invertebrate herbivore intestine-derived coenzyme. According to the glycosylation method, a sugar component of the seaweed can be effectively separated and used by glycosylating at high efficiency, the non-gradable seaweed substances which were not efficiently used before.
摘要翻译：本发明涉及使用海洋无脊椎动物食草动物肠衍生辅酶的海藻不可降解物质的糖基化方法。根据糖基化方法，通过高效糖基化可以有效地分离和使用海草中的糖成分，以前没有有效使用的不可分级的海藻物质。

2. 发明授权

KR101322478B1 ＭＭＰ 활성 억제 효과를 갖는 전복 내장 위장관 소화가수분해물 및 이를 유효성분으로 함유하는 약학 조성물 有权
标题翻译：具有抑制MMP活性的作用的鲍鱼肠胃消化物以及含有活性成分的药物组合物
公开(公告)号：KR101322478B1
公开(公告)日：2013-10-29
申请号：KR1020110092951
申请日：2011-09-15
申请人： 조선대학교산학협력단
发明人： 정원교 , 천충길 , 응구엔반띤
IPC分类号： A61K35/618 , A61K35/38 , A61K38/01 , A61K9/14
摘要： 본 발명은 MMP(Matrix metalloproteinases: 이하, 'MMP'라 함) 활성 억제 효과를 갖는 전복 내장 위장관 소화가수분해물(Abalone intestine gastro-intestinal digests: AIGID) 및 이를 유효성분으로 함유하는 MMP-2, MMP-9 활성 억제용 약학 조성물에 관한 것으로, 이들은 MMP 활성과 관련된 질환, 예컨대 암, 신경퇴행성, 심혈관 및 다양한 종류의 염증 질환을 포함한 질환을 예방 또는 치료할 수 있는 유익한 효과를 갖는다.

3. 发明公开

KR1020130029598A 항산화 및 안지오텐신전환효소 억제 효과를 갖는 전복 추출물 및 이를 함유하는 기능성 조성물 有权
标题翻译：用于抗氧化剂和血管紧张素I的转化ABALONE副产物转化酶抑制作用和含有其的功能组合物
公开(公告)号：KR1020130029598A
公开(公告)日：2013-03-25
申请号：KR1020110092952
申请日：2011-09-15
申请人： 조선대학교산학협력단
发明人： 정원교 , 천충길
IPC分类号： A61K35/60 , A61P9/12 , A61P9/00
摘要： PURPOSE: A hot water extract of abalone is provided to ensure excellent antioxidation without side effects and to suppress angiotensin I converting enzyme. CONSTITUTION: A hot water extract of abalone is prepared by desalting abalone-boiled water, filtering using an ultrafilter, and freeze-drying. A pharmaceutical composition for preventing or treating hypertension contains 0.01-99 wt% of the hot water extract as an active ingredient. A health functional food for treating hypertension contains the hot water extract as an active ingredient. [Reference numerals] (AA) ACE inhibition activity(%); (BB) Concentration(ug/mL)
摘要翻译：目的：提供鲍鱼的热水提取物，以确保优异的抗氧化，无副作用，并抑制血管紧张素I转化酶。规定：鲍鱼的热水提取物是通过使鲍鱼开水脱盐，使用超滤器过滤和冷冻干燥来制备的。用于预防或治疗高血压的药物组合物含有0.01-99重量％的热水提取物作为活性成分。用于治疗高血压的健康功能食品含有热水提取物作为活性成分。（AA）ACE抑制活性（％）（BB）浓度（ug / mL）

4. 发明公开

KR1020110130293A 전복 소화 가수분해물을 함유하는 면역계 염증성 질환 예방 및 치료용 조성물 有权
标题翻译：用于治疗和预防含有ABALONE胃肠道细菌的免疫系统中的炎症疾病的组合物
公开(公告)号：KR1020110130293A
公开(公告)日：2011-12-05
申请号：KR1020100049866
申请日：2010-05-27
申请人： 조선대학교산학협력단
发明人： 정원교 , 최일환
IPC分类号： A61K35/618 , A61K38/01 , A23L1/30 , A61K9/00
CPC分类号： A61K35/618 , A23L33/10 , A61K9/0019 , A61K9/0053 , A61K38/012
摘要： PURPOSE: A pharmaceutical composition containing abalone hydrolysate for preventing and treating inflammatory diseases in an immune system is provided to suppress NF-kappaB intranuclear transition and activation. CONSTITUTION: A pharmaceutical composition for preventing and treating inflammatory diseases in an immune system contains abalone hydrolysate as an active ingredient. The abalone hydrolysate is abalone muscle or intestine hydrolysate. The abalone hydrolysate is prepared by primary hydrolysis of the intestine of abalone and secondary hydrolysis of intestine. A neutraceutical food composition for preventing and treating inflammatory diseases contains the hydrolysate as an active ingredient.
摘要翻译：目的：提供含有用于预防和治疗免疫系统炎性疾病的鲍鱼水解产物的药物组合物，以抑制NF-κB核内转换和活化。构成：用于预防和治疗免疫系统中的炎性疾病的药物组合物含有鲍鱼水解物作为活性成分。鲍鱼水解物是鲍鱼肌肉或肠水解产物。鲍鱼水解产物是通过鲍鱼肠道的初级水解和肠的二级水解来制备的。用于预防和治疗炎性疾病的营养食品组合物含有水解产物作为活性成分。

5. 发明公开

KR1020140096194A 해양 미세조류의 바이오디젤 부산물로부터 분리된 펩티드를 유효성분으로 함유하는 고혈압의 예방 또는 치료용 약학적 조성물 无效
标题翻译：用于预防或治疗包含海洋微生物生物多样性分离的肽的高血压药物组合物
公开(公告)号：KR1020140096194A
公开(公告)日：2014-08-05
申请号：KR1020130000237
申请日：2013-01-02
申请人： 조선대학교산학협력단
发明人： 정원교 , 천충길
IPC分类号： A61K38/08 , A61K38/17 , A61P9/12 , A61P9/00
CPC分类号： A61K38/08 , A23L33/18 , A61K38/005 , A61K38/012 , C07K7/06 , Y10S530/80
摘要： The present invention relates to a pharmaceutical composition comprising a peptide isolated from biodiesel byproducts of marine microalgae as an active ingredient for preventing or treating hypertension, and a functional health food comprising the active ingredient. The pharmaceutical composition and the functional health food, according to the present invention, show inhibitory activity for angiotensin I converting enzyme (ACE), thereby having an excellent effect for preventing or treating hypertension.
摘要翻译：本发明涉及包含从海洋微藻的生物柴油副产物分离的肽作为预防或治疗高血压的活性成分的药物组合物和包含活性成分的功能性保健食品。根据本发明的药物组合物和功能保健食品显示对血管紧张素I转化酶（ACE）的抑制活性，从而具有优异的预防或治疗高血压的效果。

6. 发明授权

KR101091775B1 디에콜 화합물을 함유하는 퇴행성 신경질환 치료 및 예방용조성물 有权
标题翻译：含有Dieckol用于治疗和预防神经变性疾病的组合物
公开(公告)号：KR101091775B1
公开(公告)日：2011-12-12
申请号：KR1020080132230
申请日：2008-12-23
申请人： 조선대학교산학협력단
发明人： 정원교 , 최일환 , 이다영
IPC分类号： A61K31/357 , A61P25/28
摘要： 본발명은디에콜(Dieckol) 화합물을유효성분으로함유하는퇴행성신경질환예방및 치료용조성물에관한것으로, 보다구체적으로는, 지질다당류(lipopolysaccharide: LPS)에의하여활성화된미세아교세포(microglia)에있어서활성산소종(reactive oxygen species:ROS)의생성및 NF-&kgr;B의활성화를억제하는, 갈조류유래의디에콜(Dieckol) 화합물의용도에관한것이다. 상기디에콜화합물은퇴행성신경질환에대한치료및 예방에유용하게사용될수 있다.

7. 发明公开

KR1020100073528A 디에콜 화합물을 함유하는 퇴행성 신경질환 치료 및 예방용조성물 有权
标题翻译：含有DIECKOL用于治疗和预防神经病变疾病的组合物
公开(公告)号：KR1020100073528A
公开(公告)日：2010-07-01
申请号：KR1020080132230
申请日：2008-12-23
申请人： 조선대학교산학협력단
发明人： 정원교 , 최일환 , 이다영
IPC分类号： A61K31/357 , A61P25/28
摘要： PURPOSE: A composition containing a dieckol compound for preventing and treating neurodegerative diseases is provided to suppress ROS generation and NF-kappaB activation. CONSTITUTION: A pharmaceutical composition for preventing and treating neurodegenerative diseases contains dieckol compound of chemical formula 1 as an active ingredient. In chemical formula 1, R is hydrogen, C1-C6 alkyl, C1-C6 alkenyl, phenyl, phenylalkyl, hydroxyphenyl, or dihydroxyphenyl. The dieckol compound is isolated from brown algae, Ecklonia cava. A method for isolating dieckol compound comprises: a step of extracting Ecklonia cava powder using organic solvent; a step of fractioning organic solvent extract; a step of isolating and purifying by chromatography. The organic solvent is ethanol or methanol.
摘要翻译：目的：提供含有用于预防和治疗神经变性疾病的孕酮化合物的组合物以抑制ROS产生和NF-κB活化。构成：用于预防和治疗神经退行性疾病的药物组合物含有化学式1的甲羟戊酸化合物作为活性成分。在化学式1中，R是氢，C 1 -C 6烷基，C 1 -C 6烯基，苯基，苯基烷基，羟基苯基或二羟基苯基。米卡克醇化合物是从褐藻（Ecklonia cava）中分离出来的。一种分离甲羟戊酸化合物的方法包括：使用有机溶剂萃取Ecklonia Cava粉末的步骤; 分解有机溶剂提取物的步骤; 通过色谱分离和纯化的步骤。有机溶剂是乙醇或甲醇。

8. 发明授权

KR101373191B1 항산화효과를 가지는 미세조류 발효물 및 이를 함유하는 기능성 조성물 有权
标题翻译：发酵微藻用于抗氧化作用和含有其的功能性产品组合物
公开(公告)号：KR101373191B1
公开(公告)日：2014-03-14
申请号：KR1020110092949
申请日：2011-09-15
申请人： 조선대학교산학협력단
发明人： 정원교 , 천충길 , 정상화
IPC分类号： A61K36/02 , A61P39/06
摘要： 본 발명은 미세조류를 효모에 의해 발효시켜 그의 물질 조성 및 아미노산 조성을 변화시킴으로써 항산화 특성을 증가시킨 것을 특징으로 하는 미세조류 발효물 및 그의 항산화 용도에 관한 것이다.

9. 发明公开

KR1020140088403A 해양 미세조류의 발효물로부터 분리된 펩티드를 유효성분으로 함유하는 골질환의 예방 또는 치료용 약학적 조성물 无效
标题翻译：用于预防或治疗包含从海洋微生物分离的肽的骨髓疾病的药物组合物
公开(公告)号：KR1020140088403A
公开(公告)日：2014-07-10
申请号：KR1020130000238
申请日：2013-01-02
申请人： 조선대학교산학협력단
发明人： 정원교 , 천충길 , 정상화
IPC分类号： A61K38/08 , A61K36/03 , A61P19/00
CPC分类号： A61K38/08 , A23L33/105 , A61K35/747 , A61K36/03 , A61K2236/19
摘要： The present invention relates to a pharmaceutical composition containing peptide separated from a fermented product of marine microalgae as an active ingredient for preventing or treating bone diseases and a health functional food including the active ingredient. The pharmaceutical composition and health functional food according to the present invention performs a function of promoting the differentiation of osteoblasts so that bone diseases such as osteoporosis are prevented or treated.
摘要翻译：本发明涉及含有作为预防或治疗骨病的活性成分的海洋微藻发酵物分离出的肽的药物组合物和包含活性成分的保健功能性食品。根据本发明的药物组合物和保健功能食品具有促进成骨细胞分化的功能，从而防止或治疗骨质疏松等骨疾病。

10. 发明公开

KR1020140088402A 해양 미세조류의 바이오디젤 부산물로부터 분리된 펩티드를 유효성분으로 함유하는 골질환의 예방 또는 치료용 약학적 조성물 无效
标题翻译：用于预防或治疗包含从生物体分离的肽的骨髓疾病的药物组合物海洋微藻的产品
公开(公告)号：KR1020140088402A
公开(公告)日：2014-07-10
申请号：KR1020130000236
申请日：2013-01-02
申请人： 조선대학교산학협력단
发明人： 정원교 , 천충길
IPC分类号： A61K38/17 , A61K38/16 , A61P19/00
CPC分类号： A61K38/1767 , A23L33/18 , A61K36/02 , C07K14/405
摘要： The present invention relates to a pharmaceutical composition containing peptide separated from a biodiesel byproduct of marine microalgae as an active ingredient for preventing or treating bone diseases and a health functional food including the active ingredient. The pharmaceutical composition and health functional food according to the present invention performs a function of promoting the differentiation of osteoblasts so that bone diseases such as osteoporosis are prevented or treated.
摘要翻译：本发明涉及从海洋微藻的生物柴油副产物分离出的肽作为预防或治疗骨病的活性成分的药物组合物和包含活性成分的保健功能性食品。根据本发明的药物组合物和保健功能食品具有促进成骨细胞分化的功能，从而防止或治疗骨质疏松等骨疾病。

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