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1. 发明公开

KR1020080036580A 부분 탈아세틸화 키틴 유도체의 조성물 有权
标题翻译：部分脱乙酰氨基衍生物的组合物
公开(公告)号：KR1020080036580A
公开(公告)日：2008-04-28
申请号：KR1020087001087
申请日：2006-06-14
申请人： 제니스 에이치에프
发明人： 기슬라손요한네스 , 에이나르손욘엠 , 추엔하우엔지 , 바르케스펜
IPC分类号： C08B37/08 , C03B37/08
CPC分类号： C08B37/003 , A61K31/7008 , A61K31/722 , A61L24/08 , A61L26/0023 , A61L26/0028 , A61L26/0066 , A61L26/009 , A61L27/20 , A61L27/54 , A61L27/58 , C12P19/26 , C08L5/08
摘要： The present invention relates to compositions comprising biologically active chitinous oligomers and their endotoxin purified and partially deacetylated chitin polymer precursors, and their use in pharmaceutical compositions, biomaterial compositions, medical devices, and processes to produce the said oligomers. More specifically the present invention relates to novel compositions and processes to produce such compositions. The compositions include therapeutic hetero polymer and hetero oligomer compositions compricing specific sequences of N-acetyl glucosamine and glucosamine, developed to optimize chemical and structural features which are important for the therapeutic activity of these compositions. In addition, the present invention provides methods to use degree of deacetylation of a partially deacetylated chitin polymer in order to modulate physical and biological parameters in a calcium phosphate composite for bone implant applications.
摘要翻译：本发明涉及包含生物活性的几丁质寡聚物及其内毒素纯化和部分脱乙酰化的几丁质聚合物前体的组合物，以及它们在药物组合物，生物材料组合物，医疗装置和产生所述低聚物的方法中的用途。更具体地说，本发明涉及生产这种组合物的新型组合物和方法。组合物包括治疗性杂聚合物和杂低聚物组合物，其组合物对N-乙酰氨基葡萄糖和葡糖胺的特征性序列进行了定量，以优化对这些组合物的治疗活性重要的化学和结构特征。此外，本发明提供了使用部分脱乙酰化几丁质聚合物脱乙酰度以便调节用于骨植入物应用的磷酸钙复合材料中的物理和生物学参数的方法。

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