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    • 2. 发明公开
    • 영지추출물을 함유하는 치매의 예방 및 개선용 식품 조성물
    • 含有甘露糖提取物,奥美他啶及其结构类似物的组合物的预防和治疗组合物作为有效成分,作为阿尔茨海默氏病的血液透析和治疗效果对血管性DEMENTIA的影响
    • KR1020040111240A
    • 2004-12-31
    • KR1020040095239
    • 2004-11-19
    • 전길자김화정한소엽
    • 전길자김화정한소엽박호실조현진이지선김진형이정영이명희
    • A23L1/30
    • A23L33/10A23V2200/322A23V2250/21
    • PURPOSE: A composition for prevention and treatment of dementia containing an extract of Ganoderma lucidum(Fr.) Karst., oleamide and its structural analogue is provided. It exhibits prophylactic and therapeutic effect on vascular dementia as well as Alzheimer's disease. CONSTITUTION: The food composition for prevention and treatment of dementia contains a Ganoderma lucidum extract containing one or more effective fractions selected from GL-M, GL-M-8, GL-M-8-F-b, GL-M-8-F-b-III, GL-M-8-F-III-1. The food composition contains a compound represented by the formulae(1, 2 and 3) as an effective ingredient, wherein R1 is 9-octadecenoyl(oleyl), 9-hexadecenoly(palmitoleyl) or tetradecanoyl(myristyl). The composition inhibits the activity of acetylcholinesterase of the animal brain tissue and protecting effect on the brain tissue damaged by brain ischemia while preventing the reduction acetylcholine amount in the brain.
    • 目的:提供一种用于预防和治疗含有灵芝(Fr。)Karst。,油酰胺及其结构类似物的痴呆症的组合物。 它对血管性痴呆和阿尔茨海默病具有预防和治疗作用。 构成:用于预防和治疗痴呆的食物组合物含有灵芝提取物,其含有一种或多种选自GL-M,GL-M-8,GL-M-8-Fb,GL-M-8-Fb- III,GL-M-8-F-III-1。 食品组合物含有作为有效成分的由式(1,2和3)表示的化合物,其中R 1是9-十八烯酰基(油基),9-十六碳烯基(棕榈油基)或十四烷酰基(肉豆蔻基)。 该组合物抑制动物脑组织的乙酰胆碱酯酶的活性,并且对脑缺血损伤脑组织的保护作用,同时防止脑中的乙酰胆碱量减少。
    • 4. 发明公开
    • 영지추출물, 올레아미드 및 그의 구조적 유사체를유효성분으로 함유하는 치매의 예방 및 치료용 조성물
    • 含有GANODERMA LUCIDUM萃取物,OLEAMIDE及其结构模拟物的组合物作为有效成分,用于预防或治疗DEMENTIA
    • KR1020020090140A
    • 2002-11-30
    • KR1020020028173
    • 2002-05-21
    • 전길자김화정한소엽
    • 전길자김화정한소엽조현진박호실이지선김진형이정영이명희
    • A61K36/074A61P25/28
    • PURPOSE: A composition containing a Ganoderma lucidum extract, oleamide and a structural analogue thereof as an effective ingredient is provided. Because the composition exhibits a protecting effect on brain tissue injured by brain ischemia while preventing the reduction in an amount of acetylcholine by inhibition of AChE activity of animal brain tissue, it exhibits an effect on prevention and treatment of vascular dementia as well as Alzheimer's Disease. CONSTITUTION: The preventing and therapeutic composition for dementia contains a Ganoderma lucidum (Leyss. exFr.) Karst. extract containing GL-M, GL-M-8, GL-M-8-F, GL-M-8-F-b, GL-M-8-F-b-III, GL-M-8-F-b-III-1. The composition also contains a compound of formula 1, formula 2 and formula 3 in which R1 is 9-octadecenoyl, 9-hexadecenoyl or tetradecanoyl, R2 is 9-octadecenoyl, 9,12-octadecadienoyl or tetradecanoyl.
    • 目的:提供含有灵芝提取物,油酰胺及其结构类似物作为有效成分的组合物。 由于该组合物对由脑缺血损伤的脑组织表现出保护作用,同时通过抑制动物脑组织的AChE活性来防止乙酰胆碱的量的减少,其对预防和治疗血管性痴呆以及阿尔茨海默氏病具有影响。 构成:痴呆症的预防和治疗组合含有灵芝(Leyss.Exfr。)Karst。 含有GL-M,GL-M-8,GL-M-8-F,GL-M-8-F-b,GL-M-8-F-b-III,GL-M-8-F-b-III-1的提取物。 该组合物还含有式1,式2和式3的化合物,其中R 1为9-十八碳烯酰基,9-十六烯酰基或十四烷酰基,R 2为9-十八碳烯酰基,9,12-十八碳二烯酰基或十四烷酰基。
    • 10. 发明公开
    • 녹용으로부터 추출된 항진균제
    • 从CERVI PARVUM CORNU分离的反真菌
    • KR1020000059468A
    • 2000-10-05
    • KR1019990007089
    • 1999-03-04
    • 전길자한소엽최원자
    • 전길자최원자한소엽이윤진박현숙김영아
    • C07F9/02A61K35/32
    • C07F9/02A61K35/32
    • PURPOSE: Provided is an antifungal composition containing the extract of cervi parvum cornu as an effective ingredient. The extract shows inhibiting activity of formation of pathogenic mycelium. CONSTITUTION: The extract of cervi parvum cornu having an antifungal effect is represented by the formula (1) and is obtained by the following steps of: extracting cervi parvum cornu with hexane; extracting the extract residues with chloroform; extracting the extract residues with ethanol; obtaining CN-E by distillation under reduced pressure, in which CN-E is further purified by solubilizing in chloroform/methanol/2.5M ammonia water(20:10:2, v/v/v) solution and isolated to obtain CN-Es, or CN-Es is further purified by solubilizing in chloroform/methanol/2.5M ammonia water(20:10:2, v/v/v) solution and isolated to obtain CN-Es and then passing through the silica gel column chromatography to obtain CN-Es-6, or CN-Es-6 is further purified by solubilizing in chloroform/methanol(2:1, v/v) solution and isolated to obtain CN-Es-6s, or CN-Es-6s is further purified by solubilizing in chloroform/methanol(2:1, 1:1, 1:1.5, v/v) solution, and chloroform/methanol/2.5M ammonia water(20:10:2, v/v/v) solution and passing through the silica gel column chromatography to obtain CN-Es-6s-F, and CN-Es-6s-F is further purified by solubilizing in chloroform/methanol(50:1, 2:1, 1:1, v/v) solution, and chloroform/methanol/2.5M ammonia water(20:10:2, v/v/v) solution and passing through the silica gel column chromatography to obtain CN-Es-6s-F-d.
    • 目的:本发明提供一种抗菌组合物,其含有小檗提取物作为有效成分。 提取物显示抑制致病菌丝体形成的活性。 构成:具有抗真菌作用的小檗提取物由式(1)表示,通过以下步骤获得:用己烷萃取小檗碱; 用氯仿萃取残留物; 用乙醇提取残留物; 通过减压蒸馏获得CN-E,其中CN-E通过在氯仿/甲醇/2.5M氨水(20:10:2,v / v / v)溶液中溶解进一步纯化,分离得到CN-E 或CN-Es通过在氯仿/甲醇/2.5M氨水(20:10:2,v / v / v)溶液中溶解进一步纯化,分离,得到CN-Es,然后通过硅胶柱色谱法 通过溶解在氯仿/甲醇(2:1,v / v)溶液中进一步纯化CN-Es-6或CN-Es-6,分离得到CN-Es-6,或CN-Es-6进一步纯化 通过溶解在氯仿/甲醇(2:1,1:1,1.5,v / v)溶液和氯仿/甲醇/2.5M氨水(20:10:2,v / v / v)溶液中的溶液和 通过硅胶柱色谱法获得CN-Es-6s-F,CN-Es-6s-F通过溶解在氯仿/甲醇(50:1,2:1,1:1,v / v)中进一步纯化 )溶液和氯仿/甲醇/2.5M氨水(20:10:2,v / v / v)溶液并通过二氧化硅 凝胶柱层析,得到CN-Es-6s-F-d。