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    • 3. 发明公开
    • 세포에 부착하는 올리고펩타이드
    • 具有改善的细胞结合活性的寡肽
    • KR1020030088257A
    • 2003-11-19
    • KR1020020026334
    • 2002-05-14
    • 재단법인서울대학교산학협력재단
    • 구영장준혁정종평이승진
    • C07K7/06
    • C07K7/06A61K38/08
    • PURPOSE: An oligopeptide having improved binding activity to cells is provided. The oligopeptide can be useful for binding of artificial biomaterial such as artificial internal organs to cells. CONSTITUTION: An oligopeptide having improved binding activity to cells is provided, wherein the oligopeptide has a peptide linker between amino acids having the amino acid sequence of SEQ ID NO: 1 and SEQ ID NO: 2; the peptide linker comprises 20 amino acids; and the oligopeptide comprises the amino acid sequence of SEQ ID NO: 3. A method for binding a cell using the oligopeptide is provided, wherein the oligopeptide has a peptide linker between amino acids having the amino acid sequence of SEQ ID NO: 1 and SEQ ID NO: 2; the peptide linker comprises 20 amino acids; and the oligopeptide comprises the amino acid sequence of SEQ ID NO: 3.
    • 目的:提供具有改善的细胞结合活性的寡肽。 寡肽可用于人造生物材料如人造内脏与细胞的结合。 提供了具有改善的对细胞结合活性的寡肽,其中寡肽在具有SEQ ID NO:1和SEQ ID NO:2的氨基酸序列的氨基酸之间具有肽接头; 肽接头包含20个氨基酸; 寡肽包含SEQ ID NO:3的氨基酸序列。提供了使用寡肽结合细胞的方法,其中所述寡肽在具有SEQ ID NO:1的氨基酸序列的氨基酸和SEQ ID NO:1的氨基酸之间具有肽接头 编号:2; 肽接头包含20个氨基酸; 并且寡肽包含SEQ ID NO:3的氨基酸序列。
    • 4. 发明公开
    • 테나신 타입Ⅲ 3 절편을 이용한 신경세포 부착능 향상 방법
    • 使用细胞型III 3片段增加神经元粘连的方法
    • KR1020030086779A
    • 2003-11-12
    • KR1020020024944
    • 2002-05-07
    • 재단법인서울대학교산학협력재단
    • 정필훈장준혁서병무정종평
    • C07K14/475
    • C07K14/47A61K38/18C07K14/475
    • PURPOSE: A method for increasing the adhesion of neurons using a tenascin type III 3 fragment is provided, thereby increasing the adhesion of neurons to the artificial nervous conduit used in restoration of neurons. CONSTITUTION: A method for increasing the adhesion of neurons comprises using a polypeptide containing the tenascin type III 3 fragment, wherein the polypeptide has the amino acid sequence of SEQ ID NO: 4 or modification thereof. A method for restoration of neurons comprises using the polypeptide containing the tenascin type III 3 fragment, wherein the polypeptide has the amino acid sequence of SEQ ID NO: 4 or modification thereof. A nervous conduit coated with the polypeptide containing the tenascin type III 3 fragment is provided, wherein the polypeptide has the amino acid sequence of SEQ ID NO: 4 or modification thereof.
    • 目的:提供使用腱生蛋白III型3片段增加神经元粘附的方法,从而增加神经元对用于神经元恢复的人造神经导管的粘附。 构成:增加神经元粘附的方法包括使用含有腱生蛋白III型III片段的多肽,其中多肽具有SEQ ID NO:4的氨基酸序列或其修饰。 恢复神经元的方法包括使用含有腱生蛋白III型III片段的多肽,其中多肽具有SEQ ID NO:4的氨基酸序列或其修饰。 提供了包含含有腱生蛋白III型III片段的多肽的神经导管,其中多肽具有SEQ ID NO:4的氨基酸序列或其修饰。
    • 5. 发明授权
    • 슈반세포에 특이적으로 부착하는 올리고 펩타이드
    • 슈반세포에특이적으로부착하는올리고펩타이드
    • KR100874184B1
    • 2008-12-15
    • KR1020020024943
    • 2002-05-07
    • 재단법인서울대학교산학협력재단
    • 정필훈장준혁서병무정종평
    • C07K7/08
    • PURPOSE: An oligopeptide specifically binding to Schwann cells is provided, which is useful for treatment of damage in nerve cells. CONSTITUTION: An oligopeptide specifically binding to Schwann cells is provided, wherein the oligopeptide has the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3. The oligopeptide specifically binding to Schwann cell is isolated by inserting random amino acid sequences into a vector pFLITRIX containing the active portion of thioredoxin; transforming Escherichia coli with the vector pFLITRIX; culturing the transformed E. coli in an ampicillin containing IMC selection medium; adding tryptophane into the medium and culturing it to induce FLITRIX peptide; binding the transformed E. coli to Schwann cells fixed on a dish; selecting peptides specifically binding to the Schwann cells; and sequencing the selected peptides.
    • 目的:提供与雪旺细胞特异性结合的寡肽,其可用于治疗神经细胞的损伤。 组成:提供了与雪旺细胞特异性结合的寡肽,其中所述寡肽具有SEQ ID NO:1,SEQ ID NO:2或SEQ ID NO:3的氨基酸序列。通过插入与雪旺细胞特异性结合的寡肽 随机氨基酸序列整合到含有硫氧还蛋白活性部分的载体pFLITRIX中; 用载体pFLITRIX转化大肠杆菌; 在含有氨苄青霉素的IMC选择培养基中培养转化的大肠杆菌; 向培养基中加入色氨酸并培养它以诱导FLITRIX肽; 将转化的大肠杆菌结合到固定在培养皿上的雪旺氏细胞; 选择特异性结合许旺细胞的肽; 并对选定的肽进行测序。
    • 7. 发明公开
    • 슈반세포에 특이적으로 부착하는 올리고 펩타이드
    • 寡糖特异性结合到SCHWANN细胞
    • KR1020030086778A
    • 2003-11-12
    • KR1020020024943
    • 2002-05-07
    • 재단법인서울대학교산학협력재단
    • 정필훈장준혁서병무정종평
    • C07K7/08
    • C07K7/08C07K7/06
    • PURPOSE: An oligopeptide specifically binding to Schwann cells is provided, which is useful for treatment of damage in nerve cells. CONSTITUTION: An oligopeptide specifically binding to Schwann cells is provided, wherein the oligopeptide has the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3. The oligopeptide specifically binding to Schwann cell is isolated by inserting random amino acid sequences into a vector pFLITRIX containing the active portion of thioredoxin; transforming Escherichia coli with the vector pFLITRIX; culturing the transformed E. coli in an ampicillin containing IMC selection medium; adding tryptophane into the medium and culturing it to induce FLITRIX peptide; binding the transformed E. coli to Schwann cells fixed on a dish; selecting peptides specifically binding to the Schwann cells; and sequencing the selected peptides.
    • 目的:提供特异性结合雪旺氏细胞的寡肽,可用于治疗神经细胞损伤。 构成:提供与雪旺氏细胞特异性结合的寡肽,其中寡肽具有SEQ ID NO:1,SEQ ID NO:2或SEQ ID NO:3的氨基酸序列。通过插入特异性结合雪旺氏细胞的寡肽来分离 将随机氨基酸序列转化成含有硫氧还蛋白活性部分的载体pFLITRIX; 用载体pFLITRIX转化大肠杆菌; 在含有氨苄青霉素的IMC选择培养基中培养转化的大肠杆菌; 将色氨酸加入到培养基中并培养以诱导FLITRIX肽; 将转化的大肠杆菌与固定在盘上的施万细胞结合; 选择与雪旺氏细胞特异性结合的肽; 并对所选择的肽进行测序。