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1. 发明授权

KR100989944B1 항산화 미백 활성을 갖는 생약 혼합 추출물 有权
标题翻译：具有抗氧化活性的混合草药提取物
公开(公告)号：KR100989944B1
公开(公告)日：2010-10-26
申请号：KR1020090086309
申请日：2009-09-14
申请人： 앨트웰코스메틱 주식회사 , 장문식 , 생물공학천연물연구소(주)
发明人： 배호정 , 김경동 , 고중균 , 장문식 , 김동원 , 전옥선
IPC分类号： A61K36/61 , A61P17/18 , A61K8/97 , A61Q19/02
摘要： PURPOSE: An extract with antioxidation and whitening using natural herb mixture is provided to ensure antoxidation activity by DPPH radical removal ability and skin whitening by tyrosinase suppression. CONSTITUTION: A natural herb mixture extract with antioxidation and skin whitening contains extract of 20-40 weight% of Witch Hazel(Hamamelis Virginiana), 20-40 weight% of Eucalyptus Globulus, 5-15 weight% of Melissa Officinalis, 15-20 weight% of rosehip(Rosa canina L.), 2-8 weight% of Mentha piperita L., and 2-8 weight% of Origanum vulgare. The extract is isolated by ultrasonic extraction. A pharmaceutical composition for oxidative whitening contains the natural herb mixture extract as an active ingredient. A cosmetic composition for oxidative whitening contains the natural herb mixture extract as an active ingredient.
摘要翻译：目的：提供使用天然草本混合物抗氧化和美白的提取物，以通过DPPH自由基去除能力和通过酪氨酸酶抑制的皮肤美白来确保毒素活性。构成：具有抗氧化和皮肤美白的天然草本混合物提取物含有20-40重量％的Witch Hazel（金缕梅），20-40重量％的桉树，5-15重量％的Melissa Officinalis，15-20重量％玫瑰果的百分比（Rosa canina L.），2-8重量％的薄荷胡椒，和2-8重量％的牛至属（Origanum vulgare）。通过超声提取分离提取物。用于氧化增白的药物组合物含有天然草本混合物提取物作为活性成分。用于氧化增白的化妆品组合物含有天然草本混合物提取物作为活性成分。

2. 发明授权

KR100960263B1 피부 미백 활성을 갖는 2,4-디하이드록시신남산 에스테르 有权
标题翻译：具有配制和分解活性的2,4-羟基磷酸酯
公开(公告)号：KR100960263B1
公开(公告)日：2010-06-07
申请号：KR1020090065030
申请日：2009-07-16
申请人： 장문식
发明人： 장문식 , 주영운 , 염을균 , 김경동 , 전옥선 , 문종국 , 김동원
IPC分类号： C07C69/732 , A61K31/216 , A61K8/365
摘要： PURPOSE: A 2,4-hydroxycinnamic ester compound is provided to reduce the cytotoxin, to prevent tyrosinase from being activated, and to reduce the generation of melanin. CONSTITUTION: A 2,4-hydroxycinnamic ester compound marked with chemical formula 1, or its pharmaceutically acceptable salt is selected from the group consisting of 4-methylbenzyl 3-(2,4-dihydroxy phenyl) acrylate or 4- fluorobenzyl 3-acrylate. The 2,4-hydroxycinnamic ester compound is obtained by performing the reaction of phenyl-substituted alkyl bromide and 2,4-dihydroxy cinnamic acid under the presence of KHCO_3. A skin cosmetic composition contains the 2,4-hydroxycinnamic ester compound as an active ingredient.
摘要翻译：目的：提供2,4-羟基肉桂酯化合物以减少细胞毒素，防止酪氨酸酶被活化，并减少黑色素的产生。构成：用化学式1表示的2,4-羟基肉桂酸酯化合物或其药学上可接受的盐选自3-（2,4-二羟基苯基）丙烯酸4-甲基苄酯或3-丙烯酸4-氟苄酯。通过在KHCO 3存在下进行苯基取代的烷基溴和2,4-二羟基肉桂酸的反应，得到2,4-羟基肉桂酸酯化合物。皮肤化妆品组合物含有2,4-羟基肉桂酸酯化合物作为活性成分。

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