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1. 发明授权

KR100768685B1 단일염기다형을 포함하는 폴리뉴클레오티드, 그를 포함하는마이크로어레이 및 진단키트, 및 그를 이용한 조기폐경진단방법 失效
标题翻译：包含单核多核苷酸，微阵列和包含其的诊断试剂盒的多核苷酸以及使用该方法诊断原发性卵巢衰竭的方法
公开(公告)号：KR100768685B1
公开(公告)日：2007-10-19
申请号：KR1020060039381
申请日：2006-05-02
申请人： 의료법인 성광의료재단
发明人： 이숙환 , 이정노 , 차광렬 , 정형민 , 조성원 , 곽규범 , 차동현 , 정창조
IPC分类号： C12N15/11 , C12N15/10
摘要： A polynucleotide including single nucleotide polymorphism(SNP) derived from LAMC1 (Laminin, gamma 1) or a complementary polynucleotide thereof is provided to be used as a clinical diagnosis marker of premature ovarian failure(POF). A polynucleotide or a complementary nucleotide thereof is at least one selected from the group consisting of a polynucleotide(b) which consists of more than 10 consecutive DNA sequences, is derived from a DNA sequence described as SEQ ID : NO. 2 and has a 201st base(polymorphism) of C; a polynucleotide(d) which consists of more than 10 consecutive DNA sequences, is derived from a DNA sequence described as SEQ ID : NO. 4 and has a 201st base(polymorphism) of C; a polynucleotide(e) which consists of more than 10 consecutive DNA sequences, is derived from a DNA sequence described as SEQ ID : NO. 5 and has a 222nd base(polymorphism) of T; a polynucleotide(f) which consists of more than 10 consecutive DNA sequences, is derived from a DNA sequence described as SEQ ID : NO. 6 and has a 767th base(polymorphism) of G; a polynucleotide(g) which consists of more than 10 consecutive DNA sequences, is derived from a DNA sequence described as SEQ ID : NO. 7 and has a 767th base(polymorphism) of G; a polynucleotide(j) which consists of more than 10 consecutive DNA sequences, is derived from a DNA sequence described as SEQ ID : NO. 10 and has a 201st base(polymorphism) of A; a polynucleotide(k) which consists of more than 10 consecutive DNA sequences, is derived from a DNA sequence described as SEQ ID : NO. 11 and has a 501st base(polymorphism) of T; and a polynucleotide(l) which consists of more than 10 consecutive DNA sequences, is derived from a DNA sequence described as SEQ ID : NO. 12 and has a 201st base(polymorphism) of T.
摘要翻译：提供了包含衍生自LAMC1（层粘连蛋白，γ1）的单核苷酸多态性（SNP）或其互补多核苷酸的多核苷酸以用作早产儿卵巢功能衰竭（POF）的临床诊断标志物。多核苷酸或其互补核苷酸是选自由多于10个连续DNA序列组成的多核苷酸（b）中的至少一种，衍生自SEQ ID NO：1所示的DNA序列。 2，具有201的碱基（多态性）C; 由多于10个连续DNA序列组成的多核苷酸（d）衍生自SEQ ID NO： 4，具有201的碱基（多态性）C; 由多于10个连续DNA序列组成的多核苷酸（e）衍生自SEQ ID NO： 5，具有T的第222个碱基（多态性）由多于10个连续DNA序列组成的多核苷酸（f）衍生自SEQ ID NO： 6，具有G的第767位碱基（多态性）由多于10个连续DNA序列组成的多核苷酸（g）衍生自SEQ ID NO： 7，具有G的第767位碱基（多态性）由多于10个连续DNA序列组成的多核苷酸（j）衍生自SEQ ID NO：并具有A的201位碱基（多态性）; 由超过10个连续DNA序列组成的多核苷酸（k）衍生自SEQ ID NO： 11，具有501的碱基（多态性）; 和由多于10个连续的DNA序列组成的多核苷酸（1）衍生自SEQ ID NO： 12，并具有第201位（多态性）T.

2. 发明授权

KR101462004B1 탯줄 추출물의 제조방법 및 그의 용도 有权
标题翻译：制备脐带提取物的方法及其应用
公开(公告)号：KR101462004B1
公开(公告)日：2014-11-19
申请号：KR1020120075754
申请日：2012-07-11
申请人： (주)차바이오메드 , 의료법인 성광의료재단 , (주)차바이오텍
发明人： 최용수 , 김선미 , 김호진 , 이광형 , 정광회 , 윤태기 , 이영준 , 한규범 , 정형민
IPC分类号： C12N5/02 , C12N5/074 , A61K8/98 , C12Q1/00
CPC分类号： C12N5/0607 , A61K8/985 , A61K35/51 , A61K2800/10 , A61Q19/00 , C12N5/0018 , C12N5/0605 , C12N2502/025 , C12N2509/00
摘要： 본 발명은 탯줄로부터 유용성분을 효과적으로 추출하는 방법을 제공한다. 본 발명은 유용성분을 포함하는 탯줄 추출물을 제공한다. 본 발명의 탯줄 추출물은 동물 유래의 일반 세포 및 줄기세포 배양을 위한 혈청 대체물로 사용할 수 있다. 또한, 본 발명의 탯줄 추출물은 조직 수복용 필러, 드레싱 및 피부상태 개선용 화장료 조성물에 이용할 수 있다. 또한, 탯줄 추출물을 이용하여 탯줄, 지방 등의 조직 유래 줄기세포 분리 및 배양용 배지 조성물 그리고 이를 이용한 조직 유래 줄기세포 분리 및 배양 방법에 관한 것이다.

3. 发明公开

KR1020140008749A 탯줄 추출물의 제조방법 및 그의 용도 有权
标题翻译：用于制备脐带的提取方法及其用途
公开(公告)号：KR1020140008749A
公开(公告)日：2014-01-22
申请号：KR1020120075754
申请日：2012-07-11
申请人： (주)차바이오메드 , 의료법인 성광의료재단 , (주)차바이오텍
发明人： 최용수 , 김선미 , 김호진 , 이광형 , 정광회 , 윤태기 , 이영준 , 한규범 , 정형민
IPC分类号： C12N5/02 , C12N5/074 , A61K8/98 , C12Q1/00
CPC分类号： C12N5/0607 , A61K8/985 , A61K35/51 , A61K2800/10 , A61Q19/00 , C12N5/0018 , C12N5/0605 , C12N2502/025 , C12N2509/00
摘要： The present invention provides a method for effectively extracting useful components from an umbilical cord. The present invention provides an umbilical cord extract including the useful components. The umbilical cord extract according to the present invention can be used as a serum substitute for cultivating ordinary cells and stem cells derived from an animal. Also, the umbilical cord extract according to the present invention, can be used for a filler for tissue repair, dressing, and improving skin condition. In addition, the present invention relates to a medium composition for isolating and culturing stem cells derived from a tissue, such as an umbilical cord, fatty tissues and the like, and a method for isolating and culturing stem cells derived from the tissue using the same.
摘要翻译：本发明提供了一种从脐带有效提取有用成分的方法。本发明提供了包含有用成分的脐带提取物。根据本发明的脐带提取物可用作培养来自动物的普通细胞和干细胞的血清替代物。此外，根据本发明的脐带提取物可用于组织修复，敷料和改善皮肤状况的填料。此外，本发明涉及用于分离和培养源自组织如脐带，脂肪组织等的干细胞的培养基组合物，以及使用该组合物分离和培养源于组织的干细胞的方法。

4. 发明公开

KR1020130008178A 포유류의 탯줄유래 줄기세포 분리 또는 배양용 배지 조성물, 그리고 이를 이용한 포유류의 탯줄유래 줄기세포 분리 또는 배양 방법 无效
标题翻译：用于分离或培养MAMMALIAN脐带血干细胞的介质，以及分离或培养MAMMALIAN脐带干细胞的方法
公开(公告)号：KR1020130008178A
公开(公告)日：2013-01-22
申请号：KR1020110068761
申请日：2011-07-12
申请人： (주)차바이오텍 , (주)차바이오메드 , 의료법인 성광의료재단
发明人： 최용수 , 김선미 , 김호진 , 이영준 , 한규범 , 정형민
IPC分类号： C12N5/074 , C12Q1/02 , C12Q1/25
摘要： PURPOSE: A medium composition for isolating and culturing mammalian umbilical cord-derived stem cells is provided to quickly obtain a large amount of stem cells with excellent proliferation and differentiation abilities. CONSTITUTION: A medium composition for isolating or culturing mammalian umbilical cord-derived stem cells contains an umbilical cord extract without serum. Mammal includes human, pig, horse, cow, mouse, rat, hamster, rabbit, goat, or sheep. A method for preparing the umbilical cord extract comprises: a step of adding cut umbilical cord to a buffer solution and stirring; and a step of collecting supernatant from the mixed solution. A method for preparing the stem cells from the mammalian umbilical cord comprises: a step of culturing a blood-removed umbilical cord tissue in a container which is coated with a cell adhesion protein and contains the medium composition; and a step of treating the tissue with a medium containing stem cell lysis enzyme and isolating the stem cells. The cell adhesion protein includes mammalian umbilical cord-derived collagen, gelatin, fibronectin, laminin, or poly-D-lysine.
摘要翻译：目的：提供用于分离和培养哺乳动物脐带血干细胞的培养基组合物，以快速获得大量具有优异增殖和分化能力的干细胞。构成：用于分离或培养哺乳动物脐带源干细胞的培养基组合物含有不含血清的脐带提取物。哺乳动物包括人，猪，马，牛，老鼠，大鼠，仓鼠，兔，山羊或绵羊。制备脐带提取物的方法包括：将切割的脐带加入缓冲溶液并搅拌的步骤; 以及从混合溶液中收集上清液的步骤。用于从哺乳动物脐带制备干细胞的方法包括：在包被细胞粘附蛋白并容纳培养基组合物的容器中培养除血的脐带组织的步骤; 以及用含有干细胞裂解酶的培养基处理组织并分离干细胞的步骤。细胞粘附蛋白包括哺乳动物脐带胶原，明胶，纤连蛋白，层粘连蛋白或聚-D-赖氨酸。

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