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    • 4. 发明公开
    • 치료제로서의 프리-비-링 플라보노이드 및 플라반 혼합물의제형
    • 作为治疗药物的免费B环黄酮和FLAVANS的混合物的配制
    • KR1020070112247A
    • 2007-11-22
    • KR1020077023128
    • 2006-03-10
    • 유니젠, 인크.
    • 지아,퀴자오,유안
    • A61K31/353A61K31/70
    • A61K36/60A61K31/192A61K31/353A61K31/365A61K31/366A61K31/405A61K31/415A61K31/727A61K36/15A61K36/185A61K36/28A61K36/47A61K36/48A61K36/53A61K36/54A61K36/906A61K45/06A61K2300/00
    • The present invention provides a composition of matter comprised of a mixture of two specific classes of compounds --Free-B-Ring flavonoids and flavans- referred to herein as UP736 for use in the prevention and treatment of diseases and conditions related to platelet aggregation and platelet-induced thrombosis. The invention further provides a novel composition of matter comprised of UP736 in combination with injectable or oral anticoagulants, antiplatelet agents, non-steroidal anti-inflammatory drugs (NSAIDs) and COX-2 selective inhibitors and a method for using said composition in the prevention and treatment of diseases and conditions related to platelet aggregation and platelet-induced thrombosis. Finally, this invention provides a method for using UP736 in combination with anti-platelet, anti-coagulant, prophylaxis agents and NSAIDs as a means for reducing the dosage of these agents, decreasing the side effects associated with acute or chronic administration of these agents; counteracting or antagonizing the risks of acute or chronic administration of these agents and for achieving additional and/or multiple clinical benefits.
    • 本发明提供了由两种特定类别的化合物的混合物组成的物质组合物 - 用于预防和治疗与血小板聚集有关的疾病和病症的免费B环类黄酮和本文称为UP736的黄烷, 血小板诱导血栓形成。 本发明还提供了一种由UP736与可注射或口服抗凝剂,抗血小板剂,非甾体抗炎药(NSAID)和COX-2选择性抑制剂组合的新物质组合物,以及使用所述组合物在预防和/ 治疗与血小板聚集和血小板引起的血栓形成相关的疾病和病症。 最后,本发明提供了一种使用UP736与抗血小板,抗凝血剂,预防剂和NSAID组合的方法,作为减少这些药物剂量的方法,减少与这些药物的急性或慢性给药有关的副作用; 抵制或拮抗这些药物的急性或慢性给药的风险以及获得额外和/或多种临床益处。