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1. 发明公开

KR1020090088496A 6-(3,6-디데옥시-α-Ｌ-아라비노-헥소피라노실옥시)헵타노익산 유도체 및 그 제조 방법 无效
标题翻译： 6-（3,6-二氧杂-α--L-阿拉伯 - 十二烷氧基硅氧烷）丙二酸衍生物及其制备方法
公开(公告)号：KR1020090088496A
公开(公告)日：2009-08-20
申请号：KR1020080013796
申请日：2008-02-15
申请人： 연세대학교 산학협력단 , (주)케이디알
发明人： 정만길 , 백융기
IPC分类号： C07D309/10 , C07D407/12
摘要： A pheromone compound, 6-(3,6-dideoxy-alpha-L-arabino-hexopyranosyloxy)heptanoic acid derivative which is isolated from C. elegans is provided to massively produce pheromone and use metabolic pathway and signal transduction system development. A 6-(3,6-dideoxy-alpha-L-arabino-hexopyranosyloxy)heptanoic acid derivative is denoted by the chemical formula (I), (II) or (III). A method for producing the 6-(3,6-dideoxy-alpha-L-arabino-hexopyranosyloxy)heptanoic acid derivative comprises: a step of reacting the chemical formula (IV) and (V) to produce the chemical formula (I); a step of performing oxidation/reduction of the compound of the chemical formula (I); and a step of removing a protection residue of the compound of the chemical formula (I).
摘要翻译：提供信号素化合物，从秀丽隐杆线虫中分离得到的6-（3,6-二脱氧-α-L-阿拉伯 - 六吡喃糖基氧基）庚酸衍生物，以大量产生信息素，并使用代谢途径和信号转导系统发育。 6-（3,6-二脱氧-α-L-阿拉伯 - 六吡喃糖基氧基）庚酸衍生物由化学式（I），（II）或（III）表示。制备6-（3,6-二脱氧-α-L-阿拉伯 - 六吡喃糖基氧基）庚酸衍生物的方法包括：使化学式（IV）和（V）反应以产生化学式（I）的步骤; 进行化学式（I）的化合物的氧化/还原的步骤; 以及除去化学式（I）的化合物的保护残基的步骤。

2. 发明授权

KR100820557B1 아니소마이신을 함유하는 살선충 조성물 失效
标题翻译：包含抗生素的NEMATICIDE组合物
公开(公告)号：KR100820557B1
公开(公告)日：2008-04-08
申请号：KR1020070060486
申请日：2007-06-20
申请人： 연세대학교 산학협력단 , (주)케이디알 , 주식회사 크레아플래닛
发明人： 백융기 , 정판영 , 주효진 , 이정의 , 오완석
IPC分类号： A01N43/06 , A01N61/00 , A01P5/00
CPC分类号： A01N43/36
摘要： Anisomycin is provided to show strong nematicidal effect on Diploscapter sp. strain LKC25 and Bursaphelenchus. xylophilus, thereby being widely utilized as a prophylactic and therapeutic agent of the Diploscapter sp. strain LKC25 and Bursaphelenchus. xylophilus. A nematicidal composition comprises anisomycin represented by the formula(1). The composition has the nematicidal effect on Diploscapter sp. strain LKC25 or Bursaphelenchus. xylophilus. In the composition, 0.0001-2mM of the anisomycin is contained.
摘要翻译：提供异青霉素以显示对Diploscapter sp的强烈的杀线虫作用。菌株LKC25和Bursaphelenchus。木薯，因此被广泛用作Diploscapter sp。的预防和治疗剂。菌株LKC25和Bursaphelenchus。松材线虫。杀线虫剂组合物包含由式（1）表示的茴香霉素。该组合物对Diploscapter sp具有杀线虫效应。菌株LKC25或Bursaphelenchus。松材线虫。在组合物中，含有茴香霉素0.0001-2mM。

3. 发明公开

KR1020030000001A 콜레스테롤을 체내 합성하는 형질전환된 꼬마선충 失效
标题翻译：在体内组合的变应性婴儿胆固醇
公开(公告)号：KR1020030000001A
公开(公告)日：2003-01-03
申请号：KR1020010035622
申请日：2001-06-22
申请人： 학교법인연세대학교 , (주)케이디알
发明人： 백융기 , 이은영
IPC分类号： A01K67/033
CPC分类号： A01K67/0336 , A01K2227/703 , A01K2267/0362 , C12N15/8509
摘要： PURPOSE: Provided is transformed baby nematode wherein cholesterol is composed in vivo which imports 7-dihydrocholesterol reductase gene into baby nematode so that it is widely useful in studying the effect of cholesterol in vivo. CONSTITUTION: The transformed baby nematode wherein cholesterol is composed in vivo as Caenorhabditis elegans(KCTC 0996BP) is characterized by importing a transformed vector, in which 7-dihydrocholesterol reductase gene is imported into a vector with a promoter of heat shocking protein and cloned, and a manifestation vector(pRF4) which induces a spinning roll of the baby nematode, into normal baby nematode.
摘要翻译：目的：提供转化的婴儿线虫，其中胆固醇在体内组成，其将7-二氢胆固醇还原酶基因导入婴儿线虫中，使得其可广泛用于研究胆固醇在体内的作用。构成：其中胆固醇在体内由秀丽隐杆线虫（KCTC 0996BP）组成的转化的婴儿线虫的特征在于导入转化的载体，其中7-二氢胆固醇还原酶基因导入具有热休克蛋白启动子的载体中，并克隆，诱导婴儿线虫纺纱的表现载体（pRF4）成为正常的婴儿线虫。

4. 发明授权

KR100418187B1 콜레스테롤을 체내 합성하는 형질전환된 꼬마선충 失效
标题翻译： 콜레스테롤을체체내합성하는형질전환된꼬마선충
公开(公告)号：KR100418187B1
公开(公告)日：2004-02-11
申请号：KR1020010035622
申请日：2001-06-22
申请人： 학교법인연세대학교 , (주)케이디알
发明人： 백융기 , 이은영
IPC分类号： A01K67/033
摘要： PURPOSE: Provided is transformed baby nematode wherein cholesterol is composed in vivo which imports 7-dihydrocholesterol reductase gene into baby nematode so that it is widely useful in studying the effect of cholesterol in vivo. CONSTITUTION: The transformed baby nematode wherein cholesterol is composed in vivo as Caenorhabditis elegans(KCTC 0996BP) is characterized by importing a transformed vector, in which 7-dihydrocholesterol reductase gene is imported into a vector with a promoter of heat shocking protein and cloned, and a manifestation vector(pRF4) which induces a spinning roll of the baby nematode, into normal baby nematode.
摘要翻译：目的：提供一种转化的婴儿线虫，其中体内组成胆固醇，将7-二氢胆固醇还原酶基因导入婴儿线虫体内，因此它在体内研究胆固醇的作用方面有广泛用途。构成：转化的婴儿线虫，其中胆固醇在体内以秀丽隐杆线虫（KCTC 0996BP）构成，其特征在于进口转化的载体，其中将7-二氢胆固醇还原酶基因导入具有热休克蛋白启动子并被克隆的载体中，以及一种诱导婴儿线虫旋转滚动的表现载体（pRF4）导入正常的婴儿线虫。

5. 发明授权

KR100400877B1 항진균제의 검색방법 失效
标题翻译： 항진균제의검색방법
公开(公告)号：KR100400877B1
公开(公告)日：2003-10-08
申请号：KR1020000058565
申请日：2000-10-05
申请人： 백융기 , (주)케이디알
发明人： 백융기 , 김중호 , 김기영 , 신유경
IPC分类号： C12Q1/48
摘要： PURPOSE: A method for screening of fungicide is provided, which method can be effectively used in developing new medicines having fungicidal effects. CONSTITUTION: The method for measuring activity of fungal acyl CoA:sterol acyl transferase comprises the steps of: reacting fungal acyl CoA:sterol acyl transferase(ASAT) with sterol and acyl group as substrates; and determining the amount of sterol ester as a product of the reaction. The method for screening fungal acyl CoA:sterol acyl transferase comprises the steps of: cultivating fungal cell; treating the cultivated fungal cell with a substance assumed as an acyl CoA:sterol acyl transferase(ASAT) inhibitor; and determining the amount of oleic acid in the substance treated medium, in which the amount of oleic acid can be analyzed by using a liquid scintillation counter.
摘要翻译：目的：提供一种筛选杀真菌剂的方法，该方法可有效用于开发具有杀真菌作用的新药。构成：测量真菌酰基CoA：甾醇酰基转移酶活性的方法包括以下步骤：使真菌酰基CoA：甾醇酰基转移酶（ASAT）与甾醇和酰基作为底物; 并确定作为反应产物的甾醇酯的量。筛选真菌酰基CoA：甾醇酰基转移酶的方法包括以下步骤：培养真菌细胞; 用假定为酰基CoA：甾醇酰基转移酶（ASAT）抑制剂的物质处理栽培的真菌细胞; 并测定物质处理过的介质中油酸的量，其中可以用液体闪烁计数器分析油酸的量。

6. 发明授权

KR100556335B1 6알-(3,6-디데옥시-엘-아라비노-헥소피라노실옥시)헵타노익산, 그 제조방법 및 그를 포함하는 장기휴면 유발효과 有权
标题翻译： 6R-3,6-二羟基-L-阿拉伯 - 十二烷基硫酸，其制备方法及其对其的影响
公开(公告)号：KR100556335B1
公开(公告)日：2006-03-03
申请号：KR1020040007539
申请日：2004-02-05
申请人： 정만길 , 백융기 , (주)케이디알
发明人： 정만길 , 백융기
IPC分类号： C07H15/04 , A61K31/70
CPC分类号： C07H15/04
摘要： 본 발명은 꼬마 선충에서 발견된 노화와 스트레스억제에 관련된 페로몬인 6R-(3,6-디데옥시-L-아라비노-헥소피라노실옥시)헵타노익산의 입체화학구조 결정과 이의 전합성 그리고 장기 휴면효과에 관한 것이다. 상기 페로몬 화합물의 합성에 의하여 생체내 노화, 스트레스, 대사경로와 신호전달 체계 및 항암제 개발, 비만, 신경기관의 반응 그리고 이와 관련된 노화, 스트레스 억제 약물 개발연구에 많은 효과를 얻을 수 있게 되었다.
6R-(3,6-디데옥시-L-아라비노-헥소피라노실옥시)헵타노익산, L-람노즈, 꼬마선충(C. elegance), 페로몬, 노화, 스트레스, 장기휴면

7. 发明公开

KR1020050079353A 6알-(3,6-디데옥시-엘-아라비노-헥소피라노실옥시)헵타노익산, 그 제조방법 및 그를 포함하는 장기휴면 유발효과 有权
标题翻译： 6R-（3,6-二羟基-L-阿拉伯 - 十六烷基）硫酸，其制备方法及其效果
公开(公告)号：KR1020050079353A
公开(公告)日：2005-08-10
申请号：KR1020040007539
申请日：2004-02-05
申请人： 정만길 , 백융기 , (주)케이디알
发明人： 정만길 , 백융기
IPC分类号： C07H15/04 , A61K31/70
CPC分类号： C07H15/04 , C07H1/00
摘要： The present invention relates to a determination of a stereochemistry, a synthesis and dauer effect of 6R-(3,6-dideoxy-L-arabino-hexopyranosyloxy) heptanoic acid as a pheromone isolated from the Caenorhabditis elegance related to suppress of aging and stress. It becomes possible to develop medical substances using the pheromone relating to aging, stress, metabolism, signal transfer system in vivo, and anti-cancer, obesity and a suppressing agent for aging and stress.

8. 发明公开

KR1020020027849A 항진균제의 검색방법 失效
标题翻译：筛选杀真菌剂的方法
公开(公告)号：KR1020020027849A
公开(公告)日：2002-04-15
申请号：KR1020000058565
申请日：2000-10-05
申请人： 백융기 , (주)케이디알
发明人： 백융기 , 김중호 , 김기영 , 신유경
IPC分类号： C12Q1/48
摘要： PURPOSE: A method for screening of fungicide is provided, which method can be effectively used in developing new medicines having fungicidal effects. CONSTITUTION: The method for measuring activity of fungal acyl CoA:sterol acyl transferase comprises the steps of: reacting fungal acyl CoA:sterol acyl transferase(ASAT) with sterol and acyl group as substrates; and determining the amount of sterol ester as a product of the reaction. The method for screening fungal acyl CoA:sterol acyl transferase comprises the steps of: cultivating fungal cell; treating the cultivated fungal cell with a substance assumed as an acyl CoA:sterol acyl transferase(ASAT) inhibitor; and determining the amount of oleic acid in the substance treated medium, in which the amount of oleic acid can be analyzed by using a liquid scintillation counter.
摘要翻译：目的：提供一种筛选杀菌剂的方法，该方法可有效用于开发具有杀真菌作用的新药。构成：用于测定真菌酰基辅酶A：固醇酰基转移酶活性的方法包括以下步骤：使真菌酰基辅酶A：固醇酰基转移酶（ASAT）与固醇和酰基作为底物反应; 并测定作为反应产物的甾醇酯的量。筛选真菌酰基辅酶A：固醇酰基转移酶的方法包括以下步骤：培养真菌细胞; 用假定为酰基CoA：甾醇酰基转移酶（ASAT）抑制剂的物质处理培养的真菌细胞; 并测定物质处理过的介质中油酸的量，其中油酸的量可以通过使用液体闪烁计数器进行分析。

9. 发明授权

KR100700884B1 약학적으로 유용한 노화 및 스트레스 조절용 신규 페로몬 화합물 및 그 분리정제방법 失效
标题翻译：用于控制老化和应激的药物活性新型药物化合物及其分离和表征的方法
公开(公告)号：KR100700884B1
公开(公告)日：2007-03-29
申请号：KR1020020070591
申请日：2002-11-14
申请人： 백융기 , (주)케이디알
发明人： 정판영 , 백융기
IPC分类号： C07D309/12
CPC分类号： C07D309/10 , C07H15/04
摘要： 본 발명은 꼬마선충의 노화와 스트레스에 관련된 구조식 I을 가지는 생리학적 활성 다우어 페로몬 화합물의 효과적인 분리 및 정제방법 및 그 구조 규명을 개시한다. 우선, 꼬마선충을 에스 베이살 액체 배지 상에서 배양한 후, 액체배지를 에탄올로 완전히 농축하여서 에탄을 추출물을 얻고, 그리고 상기 에탄올 추출물을 에틸아세테이트로 다시 추출한다. 다음 실리카-겔 흡착 크로마토그래피를 이용하여 에틸아세테이트 추출물로부터 불순물을 제거하고, 다양한 용매를 용출액으로 사용하는 아민 컬럼 크로마토그래피 공정에 의하여 페로몬 추출물을 분리 및 정제한다. 마지막으로 분자량 크기를 이용한 고성능 액체 크로마토그래피 단계를 거처 구조식 I을 가지는 페로몬 화합물을 완전히 분리 및 정제한다.
꼬마선충(C. elegans), 페로몬, 노화, 스트레스, 장기휴면유충(dauer larva)

10. 发明公开

KR1020040042338A 약학적으로 유용한 노화 및 스트레스 조절용 신규 페로몬 화합물 및 그 분리정제방법 失效
标题翻译：具有老化和应力控制活性的PHEROMONE化合物及其分离方法
公开(公告)号：KR1020040042338A
公开(公告)日：2004-05-20
申请号：KR1020020070591
申请日：2002-11-14
申请人： 백융기 , (주)케이디알
发明人： 정판영 , 백융기
IPC分类号： C07D309/12
CPC分类号： C07D309/10 , C07H15/04
摘要： PURPOSE: Pheromone compound having aging and stress controlling activities, and a process for isolating the same are provided, which compound is useful for studies on aging and stress, metabolism pathway and signal transfer system, and disease development mechanism. CONSTITUTION: A pheromone compound, 6-(3,5-dihydroxy-6 -methyl-tetrahydro -pyran-2-yloxy) -heptanoic acid, having aging and stress controlling activities is represented by the formula(1). A process for isolating the pheromone compound of the formula(1) comprises the steps of: growing C. elegans in S basal broth medium, concentrating the medium and extracting the concentrated medium with ethanol; dissolving the extract in water and extracting the solution with ethylacetate; removing impurities using silica-gel adsorption chromatography; subjecting the active fraction to HPLC(High performance liquid chromatography) coupled with amine residue; and subjecting the active fraction to HPLC using the molecular weight size.
摘要翻译：目的：提供具有老化和应激控制活性的信息素化合物及其分离方法，该化合物可用于老化和应激，代谢途径和信号转导系统的研究以及疾病发展机制。构成：具有老化和应力控制活性的信息素化合物6-（3,5-二羟基-6-甲基 - 四氢 - 吡喃-2-基氧基） - 庚酸由式（1）表示。分离式（1）的信息素化合物的方法包括以下步骤：在S基础培养基培养基中生长秀丽隐杆线虫，浓缩培养基并用乙醇萃取浓缩培养基; 将提取物溶解在水中并用乙酸乙酯萃取溶液; 使用硅胶吸附色谱去除杂质; 使活性级分与胺残留物进行HPLC（高效液相色谱）反应; 并使用分子量大小使活性部分进行HPLC。

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