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    • 7. 发明公开
    • 암의 치료 또는 예방을 위한 약제학적 조성물
    • 用于治疗或预防癌症的药物组合物
    • KR1020110135018A
    • 2011-12-16
    • KR1020100054716
    • 2010-06-10
    • 연세대학교 산학협력단
    • 최강열문병산차부현
    • A61K31/37A61K31/35A61P35/00
    • PURPOSE: A pharmaceutical composition containing a compound and pharmaceutically acceptable carrier is provided to suppres Wnt/beta-catenin signal transduction system and to control Ras protein stability. CONSTITUTION: A pharmaceutical composition for preventing or treating cancer contains pharmaceutically acceptable carrier and compound of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. The cancer is caused by Ras mutation or Wnt signal transduction system disorder. The pharmaceutical composition is manufactured in a form of a tablet, capsule, pill, granule, powder, or liquid. The pharmaceutical composition is used for combination with an anticancer drug. A complex formulation contains the compound of chemical formula 1 or pharmaceutically acceptable salt thereof and the anticancer drug.
    • 目的:提供含有化合物和药学上可接受的载体的药物组合物,用于抑制Wnt /β-连环蛋白信号转导系统并控制Ras蛋白稳定性。 构成:用于预防或治疗癌症的药物组合物含有药学上可接受的载体和化学式1的化合物或其药学上可接受的盐作为活性成分。 癌症是由Ras突变或Wnt信号转导系统紊乱引起的。 药物组合物以片剂,胶囊,丸剂,颗粒剂,粉剂或液体的形式制备。 药物组合物与抗癌药物组合使用。 复合制剂含有化学式1的化合物或其药学上可接受的盐和抗癌药物。