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1. 发明授权

KR101141243B1 고리형 펩티드를 포함하는 올리고(에틸렌 글리콜) 계열 젤화제 및 이의 제조방법 有权
标题翻译：包含环肽的聚乙二醇基胶凝剂及其制备方法
公开(公告)号：KR101141243B1
公开(公告)日：2012-05-04
申请号：KR1020100005731
申请日：2010-01-21
申请人： 연세대학교 산학협력단
发明人： 장우동 , 김정아
IPC分类号： C07K17/04 , C07K17/00 , A61K9/06
摘要： PURPOSE: A method for preparing oligo(ethylene glycol) gelling agent containing cylic peptides is provided to ensure remarkable effect in gelation uniformity and time. CONSTITUTION: A gelling agent conjugated with cyclic peptides has a structure of chemical formula 1 or 2. A bio material contains the gelling agent. The bio material is a drug delivery system, bio sensor, cosmetic filling agent, cell culture medium, tissue engineering support, and chemical valve. A method for manufacturing the gelling agent of chemical formula 1 comprises: a step of coupling a compound of chemical formula 3 with a compound of chemical formula 4 to prepare a compound of chemical formula 5; a step of reacting the compound of chemical formula 5 with a compound of chemical formula 6 to prepare a compound of chemical formula 7; a step of deprotecting Boc protection group from the compound of chemical formula 7 to prepare a compound of chemical formula 8; and a step of cyclizing both end groups of the compound of chemical formula 8.

2. 发明公开

KR1020110085769A 고리형 펩티드를 포함하는 올리고(에틸렌 글리콜) 계열 젤화제 및 이의 제조방법 有权
标题翻译：包含环糊精的OLIGO（乙基甘油）基凝胶及其制备方法
公开(公告)号：KR1020110085769A
公开(公告)日：2011-07-27
申请号：KR1020100005731
申请日：2010-01-21
申请人： 연세대학교 산학협력단
发明人： 장우동 , 김정아
IPC分类号： C07K17/04 , C07K17/00 , A61K9/06
摘要： PURPOSE: A method for preparing oligo(ethylene glycol) gelling agent containing cylic peptides is provided to ensure remarkable effect in gelation uniformity and time. CONSTITUTION: A gelling agent conjugated with cyclic peptides has a structure of chemical formula 1 or 2. A bio material contains the gelling agent. The bio material is a drug delivery system, bio sensor, cosmetic filling agent, cell culture medium, tissue engineering support, and chemical valve. A method for manufacturing the gelling agent of chemical formula 1 comprises: a step of coupling a compound of chemical formula 3 with a compound of chemical formula 4 to prepare a compound of chemical formula 5; a step of reacting the compound of chemical formula 5 with a compound of chemical formula 6 to prepare a compound of chemical formula 7; a step of deprotecting Boc protection group from the compound of chemical formula 7 to prepare a compound of chemical formula 8; and a step of cyclizing both end groups of the compound of chemical formula 8.
摘要翻译：目的：提供含有环状肽的寡聚（乙二醇）胶凝剂的制备方法，以确保凝胶化均匀性和时间的显着效果。构成：与环肽结合的胶凝剂具有化学式1或2的结构。生物材料含有胶凝剂。生物材料是药物输送系统，生物传感器，化妆品填充剂，细胞培养基，组织工程支持和化学阀。制备化学式1的胶凝剂的方法包括：将化学式3的化合物与化学式4的化合物偶联以制备化学式5的化合物的步骤; 使化学式5的化合物与化学式6的化合物反应以制备化学式7的化合物的步骤; 将化学式7化合物中的Boc保护基脱保护以制备化学式8的化合物的步骤; 以及使化学式8化合物的两个端基环化的步骤。

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