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    • 2. 发明公开
    • 실험동물의 치료용 항체의 검출
    • 在实验动物中检测治疗性抗体
    • KR1020070086642A
    • 2007-08-27
    • KR1020077014471
    • 2005-12-22
    • 에프. 호프만-라 로슈 아게
    • 렌쯔헬무트스투벤라우크카이-군나르
    • G01N33/68G01N33/53G01N33/48
    • G01N33/6854C07K16/4283
    • The present invention relates to the field of therapeutic antibodies. It especially relates to the study of therapeutic antibodies in an experimental animal. The present invention discloses a method of detecting a therapeutic antibody in a sample obtained from an experimental animal comprising the steps of a) providing the sample to be analyzed, b) incubating said sample with an antibody binding to a therapeutic antibody and not binding to the immunoglobulin of said experimental animal, c) optionally incubating said sample with a reagent appropriate for the selective detection of total, active or antigen-bound therapeutic antibody, and d) correlating the complex formed in (b) or (c) to the concentration of said therapeutic antibody.
    • 本发明涉及治疗性抗体领域。 它特别涉及实验动物中治疗性抗体的研究。 本发明公开了一种检测从实验动物获得的样品中的治疗性抗体的方法,包括以下步骤:a)提供待分析的样品,b)将所述样品与结合治疗性抗体的抗体孵育, 所述实验动物的免疫球蛋白,c)任选地使用适于选择性检测总体,活性或抗原结合的治疗性抗体的试剂培养所述样品,以及d)使(b)或(c)中形成的复合物与 所述治疗性抗体。