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    • 6. 发明公开
    • 유럽종 포도의 씨 추출물을 함유하는 비만의 예방 또는 치료용 약학 조성물
    • 用于预防或治疗包含VITIS VINIFERA PIP提取物的药物的药物组合物
    • KR1020110137588A
    • 2011-12-23
    • KR1020100057601
    • 2010-06-17
    • 에이치 엘 지노믹스(주)가톨릭대학교 산학협력단
    • 조미라민준기전주연오혜좌류종현이근혁최병선조경주박진하곽은영
    • A61K36/87A61P3/04A61P3/00
    • PURPOSE: A pharmaceutical composition containing Vitis vinifera seed extract and pharmaceutically acceptable carrier is provided to prevent and treat obesity. CONSTITUTION: A pharmaceutical composition for preventing or treating obesity contains Vitis vinifera seed extract and pharmaceutically acceptable carrier. The extract has 80-130 of procyanidolic value(PCV) and contains less than 30% of (+)catechin and (-) epicatechin and 95-105% of proanthocyanidin content. A method for preparing the extract comprises: a step of mixing pulverized Vitis vinifera seed and a mixture solvent of acetone and water and isolating at room temperature; a step of filtering the extract and distilling the filtered liquid to remove acetone; a step of saturating sodium chloride and filtering; a step of extracting the liquid with ethyl acetate and concentrating; and a step of adding chloroform and filtering.
    • 目的:提供含有葡萄籽提取物和药学上可接受的载体的药物组合物以预防和治疗肥胖症。 构成:用于预防或治疗肥胖症的药物组合物含有葡萄种子提取物和药学上可接受的载体。 提取物具有80-130原花青素值(PCV),并且含有少于30%的(+)儿茶素和( - )表儿茶素和95-105%的原花色素含量。 一种制备提取物的方法包括:将经粉碎的葡萄种子和丙酮和水的混合溶剂混合并在室温下分离的步骤; 过滤提取物并蒸馏过滤的液体以除去丙酮的步骤; 使氯化钠饱和并过滤的步骤; 用乙酸乙酯萃取液体并浓缩的步骤; 并加入氯仿和过滤步骤。