专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

KR1020040008458A 항암제 내성을 갖는 뉴클레오포스민 유전자, 및 이의이용방법 无效
标题翻译：具有抗癌药物耐受性的核苷酸基因及其用途
公开(公告)号：KR1020040008458A
公开(公告)日：2004-01-31
申请号：KR1020020042096
申请日：2002-07-18
申请人： 에스케이 주식회사
发明人： 조재훈 , 조수진 , 주홍신 , 유영도
IPC分类号： C12N15/12
CPC分类号： C07K14/47 , G01N33/502 , G01N33/5044 , G01N2800/44
摘要： PURPOSE: A nucleophosmin gene having anticancer agent tolerance and the use thereof are provided. The nucleophosmin gene is used for the diagnosis of anticancer agent tolerance and for the prescription of an anticancer agent optimized for a patient. CONSTITUTION: A nucleophosmin gene having anticancer agent tolerance has the nucleotide sequence of SEQ ID NO: 1. A method for screening a drug for overcoming the anticancer agent tolerance comprises the steps of: inserting the nucleophosmin gene of SEQ ID NO: 1 into a cancer cell and expressing it within the cancer cell; administrating an anticancer agent or an anticancer agent tolerance overcoming drug to the cancer cell; and analyzing proliferation of the cancer cell, wherein the cancer cell is a lung cancer cell or a stomach cancer cell; and the anticancer agent is selected from cisplatin, carboplatin, taxol, adriamycin, fluorouracil(5-FU), and etoposide(VP-16). A method for diagnosis of anticancer agent tolerance comprises analysis of expression of the nucleophosmin gene within the cancer cell.
摘要翻译：目的：提供具有抗癌剂耐受性的核磷酸基因及其用途。核磷酸基因用于诊断抗癌药物耐受性和用于为患者优化的抗癌剂的处方。构成：具有抗癌剂耐受性的核磷酸基因具有SEQ ID NO：1的核苷酸序列。用于筛选药物以克服抗癌剂耐受性的方法包括以下步骤：将SEQ ID NO：1的核磷酸基因插入癌症并在癌细胞内表达; 向癌细胞施用克服药物的抗癌剂或抗癌剂耐受性; 并分析癌细胞的增殖，其中所述癌细胞是肺癌细胞或胃癌细胞; 抗癌剂选自顺铂，卡铂，紫杉醇，阿霉素，氟尿嘧啶（5-FU）和依托泊苷（VP-16）。用于诊断抗癌药物耐受性的方法包括分析癌细胞内核磷酸基因的表达。

IPRDB

热门服务

关于我们

友情链接

联系方式