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    • 3. 发明公开
    • 진세노사이드 Rg3(S)가 인리치먼트된 발효인삼 또는 발효홍삼 제조방법
    • 制备金刚石或红松石的方法RG3(S)
    • KR1020160029955A
    • 2016-03-16
    • KR1020140119054
    • 2014-09-05
    • 경희대학교 산학협력단
    • 최도영남동우유제혁이승훈최혁재유홍석
    • A61K36/258A61K31/704A61K35/74
    • A61K36/258A23L19/00A23L33/00A61K31/704A61K35/74
    • 본발명은 (a) 락토바실러스파라카제이 ATCC 25180 균주, 락토바실러스플란타럼 ATCC 39268 균주또는이의조합을인삼또는홍삼에접종하는단계; 및 (b) 단계 (a)의균주를배양하여인삼또는홍삼에함유된진세노사이드를진세노사이드 Rg3으로생물전환시키는단계를포함하는발효인삼또는발효홍삼의제조방법및 진세노사이드 Rg3의인리치먼트(enrichment) 방법을제공한다. 본발명에의하여특정균주를이용하여간단한공정으로인삼또는홍삼에포함된진세노사이드를전환하여, 인삼또는홍삼의진세노사이드 Rg3(특히, 진세노사이드 Rg3(S))를인리치먼트시킬수 있다. 또한, 본발명에따르면진세노사이드 Rg3(특히, 진세노사이드 Rg3(S))가인리치먼트되어있는우수한효능의인삼또는홍삼을제공할수 있다.
    • 提供发酵人参或发酵红参的制造方法以及人参皂甙Rg3的富集方法。 制造发酵人参或发酵红参的方法包括以下步骤:(a)用干酪乳酸杆菌ATCC 25180菌株,植物乳杆菌ATCC 39268菌株或其组合接种人参或红参; 和(b)培养步骤(a)的菌株以将人参或红参中包含的人参皂苷生物转化为人参皂甙Rg3。 根据本发明,通过使用特定菌株通过简单的方法转化人参或红参中包含的人参皂苷,可以富集人参或红参中人参皂甙Rg3(特别是人参皂苷Rg3(S))。 此外,根据本发明,可以提供含有浓缩人参皂甙Rg3(特别是人参皂苷Rg3(S))的具有优异功效的人参或红参。
    • 8. 发明公开
    • 독활 및 만형자의 혼합 생약 추출물을 유효성분으로함유하는 관절염의 예방 및 치료용 조성물
    • 包含ARALIA CORDATA THUNB和VITEX ROTUNDIFOLIA L.混合提取物的组合物用于预防和治疗ARTHRITIS
    • KR1020080055205A
    • 2008-06-19
    • KR1020060128211
    • 2006-12-14
    • 경희대학교 산학협력단
    • 박동석유명철최도영이재동백용현허정은조용백한창균이해인정기원
    • A61K36/25A61K36/85A61P19/02
    • A composition comprising the mixed extracts of Aralia cordata THUNB and Vitex rotundifolia L. fil is provided to suppress edema and pain, inhibit proteoglycan in articular cartilage cell and activity of MMP-1(matrix metalloproteinase-1) and MMP-3, and induce no cytotoxicity and morphological change, so that the composition is useful for preventing and treating arthritis. A pharmaceutical or health food composition for preventing and treating arthritis comprises 0.1-50 wt.% of the mixed extracts of Aralia cordata THUNB and Vitex rotundifolia L. fil which are prepared by extracting them with water, C1-C4 lower alcohol including methanol or ethanol, or a mixed solvent thereof, wherein the arthritis is degenerative arthritis, rheumatoid arthritis or Lupus arthritis; and the daily dosage of the mixed extracts is 0.01mg/kg-10g/kg, preferably 1 mg/kg-1g/kg.
    • 提供包含Aralia cordata THUNB和Vitex rotundifolia L. fil的混合提取物的组合物,以抑制水肿和疼痛,抑制关节软骨细胞中的蛋白聚糖和MMP-1(基质金属蛋白酶-1)和MMP-3的活性,并诱导无 细胞毒性和形态变化,使得该组合物可用于预防和治疗关节炎。 用于预防和治疗关节炎的药物或保健食品组合物包括通过用水,C1-C4低级醇(包括甲醇或乙醇)提取它们制备的Aralia cordata THUNB和Vitex rotundifolia L. fil的混合提取物的0.1-50重量% 或其混合溶剂,其中所述关节炎是退行性关节炎,类风湿性关节炎或狼疮性关节炎; 混合提取物的日剂量为0.01mg / kg-10g / kg,优选为1mg / kg-1g / kg。
    • 10. 发明公开
    • 희첨 추출물을 포함하는 관절염의 예방 및 치료용 조성물
    • 组合物包括提取和治疗ARTHRITIS
    • KR1020070076613A
    • 2007-07-25
    • KR1020060005684
    • 2006-01-19
    • 경희대학교 산학협력단
    • 박동석유명철최도영이재동조용백김남재조은미
    • A61K36/28A61P19/02
    • A61K36/28A23L33/105A23V2002/00A23V2250/21A23V2200/324
    • Provided is a composition comprising an extract of Siegesbeckiae Herba which is able to inhibit the decomposition of proteoglycan and collagen, has the cartilage protecting effect with the MMP-1, MMP-3 and MMP-13 activity inhibitory effects in chondrocyte and cartilaginous tissue, is able to inhibit edema significantly in an animal model induced by arachidonic acid and croton oil and has the pain inhibitory effect and inflammation inhibitory effect, so that it is usefully used for effectively treating and preventing arthritis. The pharmaceutical composition for preventing and treating arthritis comprises an extract of Siegesbeckiae Herba as an effective ingredient, wherein the arthritis is degenerative arthritis, rheumatoid arthritis or lupus arthritis and the extract is prepared from a solvent selected from the group consisting of water, C1-4 alcohol, and a mixture thereof. The health functional food comprises the extract of Siegesbeckiae Herba and is in the form of powder, granule, tablet, capsule or drink.
    • 本发明提供能够抑制蛋白聚糖和胶原分解的Siegesbeckiae Herba提取物的组合物,具有软骨细胞和软骨组织中MMP-1,MMP-3和MMP-13活性抑制作用的软骨保护作用, 能够在由花生四烯酸和巴豆油诱导的动物模型中显着抑制水肿,具有抑制抑制作用和炎症抑制作用,有效地用于有效治疗和预防关节炎。 用于预防和治疗关节炎的药物组合物包括Siegesbeckiae Herba的提取物作为有效成分,其中所述关节炎是退行性关节炎,类风湿性关节炎或狼疮关节炎,并且所述提取物由选自水,C1-4 醇及其混合物。 健康功能食品包括Siegesbeckiae Herba的提取物,呈粉末,颗粒,片剂,胶囊或饮料的形式。