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    • 5. 发明公开
    • 주름 개선 효과가 우수한 생약 추출물 및 이의 제조방법
    • 具有抗皱效果的草本提取物及其制备方法
    • KR1020050029556A
    • 2005-03-28
    • KR1020030065882
    • 2003-09-23
    • 에스케이케미칼주식회사
    • 이순근한창균김주현정칠만윤세준
    • A61K8/97A61Q19/08
    • A61K8/97A61K8/63A61K2800/72A61Q19/08
    • Herbal extracts having anti-wrinkle effect and a preparation method thereof are provided, which herbal extracts have fibroblast growth effect, collagen biosynthesis stimulating effect, elastin synthesis stimulating effect, skin immunity increasing effect, free radical removing effect, antioxidative effect, photoaging inhibiting effect, skin wound treating effect and skin moisturing effect. The method for preparing the herbal extracts having anti-wrinkle effect comprises the steps of: (1) extracting leaf of Panax ginseng C.A. Meyer, young root of Panax ginseng C.A or a mixture thereof with methanol at 60 to 80 deg. C, filtering the extract of Panax ginseng C.A, and concentrating it under reduced pressure; (2) treating the concentrate with hexane to remove a fat layer fraction, adding butanol into the hexane treated concentrate to isolate a butanol layer, and concentrating the butanol layer under reduced pressure; (3) dissolving the butanol layer concentrate in water, adsorbing the dissolved solution to the reverse phase column, and washing the column with 30% methanol solution to obtain a crude saponin fraction; (4) dissolving the crude saponin fraction in a mixed solution of ethylacetate and propanol to obtain Panaxadiol-type Ginsenosides, and concentrating the Panaxadiol-type Ginsenosides under reduced pressure; (5) dissolving the Ginsenoside powder in hydrochloric acid solution, heating the solution at 60 to 80 deg. C, and cooling the solution to obtain micro-crystal precipitate; and (6) filtering the precipitate and drying the filtered precipitate under reduced pressure to obtain Ginsenoside Rg3 containing powder.
    • 提供具有抗皱作用的草药提取物及其制备方法,其中草药提取物具有成纤维细胞生长作用,胶原合成刺激作用,弹性蛋白合成刺激作用,皮肤免疫增加作用,自由基去除效果,抗氧化作用,光老化抑制作用, 皮肤伤口治疗效果和皮肤保湿效果。 制备具有抗皱效果的草药提取物的方法包括以下步骤:(1)提取人参C.A.的叶子。 迈耶,人参C.A的青根或其与甲醇的混合物在60至80度。 C,过滤人参C.A的提取物,减压浓缩; (2)用己烷处理浓缩物以除去脂肪层部分,向己烷处理的浓缩物中加入丁醇以分离丁醇层,并在减压下浓缩丁醇层; (3)将丁醇层浓缩物溶解在水中,将溶解溶液吸附到反相柱中,用30%甲醇溶液洗涤柱,得到粗皂苷级分; (4)将粗皂苷馏分溶解在乙酸乙酯和丙醇的混合溶液中,得到三七二醇型人参皂甙,减压浓缩三七二醇型人参皂甙; (5)将人参皂甙粉末溶解在盐酸溶液中,在60〜80℃加热溶液。 并冷却溶液,得到微晶沉淀物; 和(6)过滤沉淀物并在减压下干燥过滤的沉淀物,得到含有人参皂苷Rg3的粉末。
    • 10. 发明公开
    • 치매치료 효과를 갖는 백두옹 추출물
    • 具有通过β-淀粉样蛋白抑制神经元细胞毒性并增强记忆和包含其的组合的DEMENTIA治疗效果的PULSATILLA KOREANA NAKAI的提取物
    • KR1020050023711A
    • 2005-03-10
    • KR1020030061095
    • 2003-09-02
    • 에스케이케미칼주식회사
    • 최원락한창균서정우임광진정칠만윤세준곽의종김태곤
    • A61K36/23A61P25/28
    • A61K36/71A23L33/105A23V2002/00A23V2200/322
    • PURPOSE: An extract of Pulsatilla koreana Nakai having dementia treating effect and a composition comprising the same extract are provided, which Pulsatilla koreana Nakai extract or fraction thereof inhibits neuronal cell toxicity by beta-amyloid, and enhances memory, so that it can be useful in medicines or health foods for dementia treatment and brain function enhancement. CONSTITUTION: The composition for dementia treatment and brain function enhancement comprises the extract of Pulsatilla koreana Nakai, wherein the Pulsatilla koreana Nakai extract is prepared by (1) extracting Pulsatilla koreana Nakai with lower alcohol, (2) concentrating the lower alcohol extract of Pulsatilla koreana Nakai under reduced pressure to remove remained alcohol and obtain lower alcohol fraction, and (3) purifying the lower alcohol fraction with the column using eluting solvent of methanol.
    • 目的:提供具有痴呆症治疗效果的白头翁白菜提取物和包含相同提取物的组合物,其中白头翁白喉提取物或其部分通过β-淀粉样蛋白抑制神经元细胞毒性并增强记忆,从而可用于 用于痴呆症治疗和脑功能增强的药物或保健食品。 构成:痴呆症治疗和脑功能改善的组合物包括白头翁白菜提取物,其中白头翁白菜提取物是通过以下方法制备的:(1)用低级醇提取白头翁白菜,(2)浓缩白头翁的低级酒精提取物 Nakai在减压下除去残留的醇并获得较低的醇馏分,和(3)用柱子使用甲醇洗脱溶剂纯化低级醇馏分。