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    • 2. 发明公开
    • 도파민 D3 수용체 조절에 반응하는 질환 치료용으로 적합한 6-아미노(아자)인단 화합물
    • 适用于治疗多巴胺D3受体调节障碍的6-AMINO(AZA)INDANE化合物
    • KR1020070069203A
    • 2007-07-02
    • KR1020077010956
    • 2005-10-14
    • 애보트 게엠베하 운트 콤파니 카게
    • 드레셔칼라하우프트안드레아스운거릴리아네터너신씨브라제빌프라이트그란델롤란
    • C07D221/04C07D239/38C07D333/34C07D409/12
    • C07D239/38C07C311/21C07C2601/02C07C2601/04C07C2602/08C07D221/06C07D333/34C07D401/12C07D409/12
    • The present invention relates to 6-amino(aza)indane compound of the formula (I) Wherein Ar is phenyl or an aromatic 5-or 6-membered C-bound heteroaromatic radical, wherein Ar may carry 1 radical Ra and wherein Ar may also carry I or 2 radicals Rb; X is N or CH; E is CR6R7 or NR 3; R1 is C 1-C4-alkyl, C3-C4-cycloalkyl, C3-C4-cycloalkylmethyl, C3-C4-alkenyl, fluorinated C1-C4-alkyl, fluorinated C3-C4-cycloalkyl, fluorinated C3-C4-cycloalkylmethyl, fluorinated C3-C4-alkenyl, formyl or C1-C3-alkylcarbonyl; R1a is H or R1a and R2 or R1a and R2a together are (CH2)n with n being 1, 2, 3 or 4; R2 and R2a each independently are H, CH3, CH2F, CHF2 or CF3; R3 is H or C,-C4-alkyl; and the physiologically tolerated acid addition salts of these compounds. The invention also relates to pharmaceutical compositions comprising at least one compound of the formula (I) or a pharmaceutically acceptable salt thereof and to a method for treating a medical disorder susceptible to treatment with a dopamine D3 receptor ligand, said method comprising administering an effective amount of at least one compound of the formula (I) or a pharmaceutically acceptable salt thereof.
    • 本发明涉及式(I)的6-氨基(氮杂)二氢化茚化合物,其中Ar是苯基或芳族5-或6-元C-结合的杂芳族基团,其中Ar可以携带1个基团Ra,其中Ar也可以 携带I或2个基团Rb; X为N或CH; E为CR6R7或NR3; R 1是C 1 -C 4烷基,C 3 -C 4环烷基,C 3 -C 4环烷基甲基,C 3 -C 4链烯基,氟化C 1 -C 4烷基,氟化C 3 -C 4环烷基,氟化C 3 -C 4环烷基甲基,氟化C 3 -C4-烯基,甲酰基或C1-C3-烷基羰基; R1a是H或R1a,R2或R1a和R2a同时为(CH2)n,n为1,2,3或4; R2和R2a各自独立地为H,CH3,CH2F,CHF2或CF3; R3是H或C,-C4-烷基; 和这些化合物的生理上耐受的酸加成盐。 本发明还涉及包含至少一种式(I)化合物或其药学上可接受的盐的药物组合物和治疗易受多巴胺D3受体配体治疗的医学病症的方法,所述方法包括给予有效量 的至少一种式(I)化合物或其药学上可接受的盐。