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1. 发明公开

KR1020000029709A 3-하이드록시메틸세팔로스포린의용매추출법 无效
标题翻译：溶剂萃取3-羟基甲基吗啉
公开(公告)号：KR1020000029709A
公开(公告)日：2000-05-25
申请号：KR1019997000810
申请日：1997-07-18
申请人： 브리스톨-마이어즈 스퀴브 컴페니
发明人： 림게리엠.에프. , 루비존엠. , 오디아비키에이취.
IPC分类号： C07D501/12
CPC分类号： C07D501/00
摘要： PURPOSE: The cephalosporin intermediates, desacetyl 7-glutaryl ACA and desacetyl cephalosporin D, are obtained in the form of a concentrated aqueous solution from an aqueous solution containing said intermediates in less concentrated form by solvent extraction using cyclohexanone followed by back-extraction into water. The concentrated aqueous solution of intermediate is in a form which can be used for economical production of 7-ACA using known procedures. CONSTITUTION: Provided is a process for preparing concentrated ( > 10% weight/volume)aqueous solutions of desacetyl 7 glutaryl ACA or desacetyl cephalosporin D from an aqueous solution, preferably an aqueous fermentation broth and most preferably a processed fermentation broth, containing the desacetyl 7-glutaryl ACA or desacetyl cephalosporin D in lower concentration, which comprises the steps of: (a) providing an aqueous solution, preferably a fermentation broth and most preferably a processed fermentation broth, containing desacetyl 7-glutaryl ACA or desacetyl cephalosporin D; (b) contacting the solution with cyclohexanone at a pH of from about 1.5 to about 3 so as to extract the desacetyl 7-glutaryl ACA or desacetyl cephalosporin D into the cyclohexanone solvent phase; (c) separating the cyclohexanone solvent phase from the aqueous phase; (d) contacting the cyclohexanone phase with water at a pH of from about 5 to about 7.5; and (e) separating the aqueous phase containing the desired concentrated solution of desacetyl 7-glutaryl ACA or desacetyl cephalosporin D.
摘要翻译：目的：通过使用环己酮的溶剂萃取，然后通过反萃取到水中，以浓缩形式从含有所述中间体的水溶液的浓缩水溶液形式得到头孢菌素中间体脱乙酰基-7-戊二酰ACA和脱乙酰头孢菌素D。中间体的浓缩水溶液是可以用于使用已知方法经济地生产7-ACA的形式。构成：提供从水溶液，优选含水发酵液，最优选含有脱乙酰基7的加工发酵液制备浓缩（> 10％重量/体积）脱乙酰基7戊二酰基ACA或去乙酰基头孢菌素D的水溶液的方法（a）提供含有脱乙酰基7-戊二酰基ACA或脱乙酰头孢菌素D的发酵液，最优选加工的发酵肉汤的水溶液，（a）提供较低浓度的α-葡萄糖醛酸ACA或脱乙酰基头孢菌素D，（b）将溶液与环己酮在约1.5至约3的pH下接触，以将脱乙酰基7-戊二酰基ACA或脱乙酰基头孢菌素D提取到环己酮溶剂相中; （c）将环己酮溶剂相与水相分离; （d）将环己酮相与约5至约7.5的pH接触; 和（e）分离含有所需浓缩的去乙酰基7-戊二酰基ACA或脱乙酰头孢菌素D的浓缩溶液的水相。

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