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    • 2. 发明公开
    • 평활근 이완활성을 지닌 신경성 펩타이드
    • 具有平滑肌肉松弛活性的神经细胞
    • KR1020060115052A
    • 2006-11-08
    • KR1020050037342
    • 2005-05-04
    • 부경대학교 산학협력단
    • 박남규김은정김찬희고혜진김인혜홍용기윤호동박희연장영채
    • C07K7/08C07K7/06
    • C07K7/06A61K38/08C12N15/81C12N2510/02
    • A neuropeptide having relaxing activity of smooth muscle is provided to improve smooth muscle-relaxing activity, and reduce the number of amino acids, so that the neuropeptide is mass produced. The neuropeptide having relaxing activity of smooth muscle has the amino acid sequence of SEQ ID NO:2, wherein the C-terminal is carboxylated or amidated and the amine group of N-terminal is substituted by alkyl or acetyl group; the amino acid sequence is L-type and/or D-type. A nucleic acid containing DNA or RNA encodes the neuropeptide of SEQ ID NO:2. A recombinant vector contains the nucleic acid. The neuropeptide having relaxing activity of smooth muscle is produced by transforming bacterium, yeast or fungus with the recombinant vector, and culturing the transformed microorganism. A composition is used for improving at least one symptom selected from bronchial asthma, hypertension, diuresis and impotence.
    • 提供具有平滑肌松弛活性的神经肽,以提高平滑肌松弛活性,减少氨基酸数量,从而大量生产神经肽。 具有平滑肌松弛活性的神经肽具有SEQ ID NO:2的氨基酸序列,其中C末端被羧基化或酰胺化,并且N-末端的胺基被烷基或乙酰基取代; 氨基酸序列是L型和/或D型。 含有DNA或RNA的核酸编码SEQ ID NO:2的神经肽。 重组载体含有核酸。 具有平滑肌松弛活性的神经肽通过用重组载体转化细菌,酵母或真菌产生,并培养转化的微生物。 一种组合物用于改善选自支气管哮喘,高血压,利尿和阳at的至少一种症状。
    • 4. 发明公开
    • 실라카 비드를 포함하는 생물 촉매 고정화용 담체, 및 이의용도
    • 用于固定包含二氧化硅珠的生物质的支持及其用途
    • KR1020080073188A
    • 2008-08-08
    • KR1020070061110
    • 2007-06-21
    • 부경대학교 산학협력단
    • 이재화김인혜김인관김영수박창수
    • C12N11/06C01B33/00B01J32/00
    • A support for immobilizing a biocatalyst and an enzyme immobilized thereon are provided to be harmless to human body and possible to be reused, show increased stability, and be easy to control reactivity, pH and temperature, thereby being widely used in a food or a medicine related industry. A support for immobilizing a biocatalyst comprises silica bead of which an outer layer is crosslinked with chitosan and casein, wherein the silica bead has a pore size of 50-1,000 angstrom. An immobilized enzyme is characterized in that the support for immobilizing the biocatalyst and an enzyme such as alpha-amylase of Bacillus licheniformis are bonded by an amide bond. To degrade starch, the immobilized alpha-amylase is used.
    • 提供固定化生物催化剂和固定在其上的酶的载体,对人体无害,可重复使用,显示出增加的稳定性,并且易于控制反应性,pH和温度,从而广泛用于食品或药物 相关行业。 用于固定生物催化剂的载体包括其外层与壳聚糖和酪蛋白交联的二氧化硅珠粒,其中二氧化硅珠粒的孔径为50-1,000埃。 固定化酶的特征在于用于固定生物催化剂的载体和酶例如地衣芽孢杆菌的α-淀粉酶通过酰胺键键合。 为了降解淀粉,使用固定的α-淀粉酶。