专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

KR1020080003388A 진단 및 치료 방법, 및 이에 유용한 제제 无效
标题翻译：一种诊断和治疗方法及其相关的试剂
公开(公告)号：KR1020080003388A
公开(公告)日：2008-01-07
申请号：KR1020077025263
申请日：2006-03-31
申请人： 메드벳 싸이언스 피티와이. 리미티드
发明人： 브라운마이클폴
IPC分类号： G01N33/574 , G01N33/53 , G01N33/577 , A61K51/10
CPC分类号： G01N33/573 , C07K16/40 , G01N33/5011 , G01N33/57488 , G01N2800/52
摘要： The present invention relates generally to a method of screening for the level of neoplastic cell death in a subject. More particularly, the present invention provides a method of screening for the level of neoplastic cell death by detecting the level of expression of telomerase protein and/or gene by dead cells in said subject or in a biological sample derived from said subject. The method of the present invention is useful in a range of applications including, but not limited to, assessing a neoplastic condition, monitoring the progression of such a condition, assessing the effectiveness of a therapeutic agent or therapeutic regime and predicting the likelihood of a subject either progressing to a more advanced disease state or entering a remissive state. The present invention also provides diagnostic agents useful for detecting telomerase protein and/or nucleic acid molecules.
摘要翻译：本发明一般涉及筛选受试者中肿瘤细胞死亡水平的方法。更具体地，本发明提供了一种通过检测所述受试者或衍生自所述受试者的生物样品中的死细胞的端粒酶蛋白和/或基因的表达水平来筛选肿瘤细胞死亡水平的方法。本发明的方法可用于一系列应用，包括但不限于评估肿瘤状况，监测这种病症的进展，评估治疗剂或治疗方案的有效性以及预测受试者的可能性要么进展到更为先进的疾病状态，要么进入缓和状态。本发明还提供了可用于检测端粒酶蛋白和/或核酸分子的诊断剂。

2. 发明公开

KR1020050114217A 진단 및 치료 방법 无效
标题翻译：诊断和治疗方法
公开(公告)号：KR1020050114217A
公开(公告)日：2005-12-05
申请号：KR1020057015494
申请日：2004-02-23
申请人： 메드벳 싸이언스 피티와이. 리미티드
发明人： 브라운마이클폴
IPC分类号： A61K39/385 , A61K39/44 , A61K49/00 , A61P35/00
CPC分类号： G01N33/57488 , A61K47/6843 , A61K51/1018 , C07K16/18 , G01N33/5017 , G01N33/6875 , G01N2510/00
摘要： The present invention relates generally to a method for detecting an aberrant cell, and more particularly an apoptotic cell, in a subject or in a biological sample from said subject, and agents useful for same. The presence of the aberrant cell or group of aberrant cells provides an indication of a particular disease or condition or a propensity for development of a disease or condition. More particularly, the present invention contemplates a method for detecting an apoptotic cell by detecting the presence of extranuclear nuclear molecules, in particular La, or a relative increase in extranuclear nuclear molecule levels. The present invention further provides a method for diagnosing or monitoring conditions characterised by aberrant, unwanted or otherwise inappropriate cellular apoptosis in a subject or in a biological sample from said subject by screening for up-regulation of extranuclear nuclear molecule levels in a cell or group of cells. The present invention provides diagnostic agents useful for detecting these molecules. Such diagnostic agents include immunointeractive molecules, such as antibodies.
摘要翻译：本发明一般涉及一种用于检测受试者或来自所述受试者的生物样品中的异常细胞，特别是凋亡细胞的方法和可用于其的试剂。异常细胞或异常细胞群的存在提供特定疾病或病症的指示或发展疾病或病症的倾向。更具体地，本发明考虑了通过检测核内核分子（特别是La）的存在或核内核分子水平的相对增加来检测凋亡细胞的方法。本发明进一步提供一种用于诊断或监测特征在于受试者或来自所述受试者的生物样品中异常，不需要的或其它不适当的细胞凋亡的病症的方法，其筛选细胞或组的核内核分子水平的上调细胞。本发明提供了可用于检测这些分子的诊断剂。这样的诊断剂包括免疫相互作用分子，如抗体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式