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    • 6. 发明公开
    • 항알러지성 유효성분에 대한 생체 외 스크리닝 시스템
    • 建立房屋尘埃诱发的人体细胞系疾病筛查系统,疟原虫PTERONISSINUS
    • KR1020100023360A
    • 2010-03-04
    • KR1020080082075
    • 2008-08-21
    • 대전대학교 산학협력단
    • 윤치영이지숙김인식
    • C12Q1/04C12N5/071
    • G01N33/5008G01N2500/10
    • PURPOSE: An in vitro screening system to anti-allergy active ingredient is provided to screen anti-allergic material and use screened material as a therapeutic agent for atopic dermatitis. CONSTITUTION: A method for screening anti-allergy material through in vitro screening system to anti-allergy active ingredient comprises: a step of inducing generation of inflammatory cytokine and chemokine using dust mites which is a main antigen of atopic dermatitis; a step of contacting various anti-allergy material to cell line of human; and a step of measuring the suppression by the dust mites. The inflammatory chemokine and cytokine is MCP-1(monocyte chemoattractent protein -1) and IL-6(interleukin-6) and IL-8.
    • 目的:提供抗过敏活性成分的体外筛选系统,筛选抗过敏材料,并使用筛选材料作为特应性皮炎的治疗剂。 构成:通过体外筛选系统对抗过敏活性成分筛选抗过敏材料的方法包括:使用作为特应性皮炎主要抗原的尘螨引起炎症细胞因子和趋化因子的产生的步骤; 将各种抗过敏材料接触人的细胞系的步骤; 以及测量尘螨抑制的步骤。 炎性趋化因子和细胞因子是MCP-1(单核细胞趋化蛋白-1)和IL-6(白细胞介素-6)和IL-8。