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    • 6. 发明公开
    • 나트륨 이온 구동형 클로라이드/비-카르보네이트 익스체인저
    • 四氯化碳/二氯乙烷交换器
    • KR1020020013454A
    • 2002-02-20
    • KR1020010048008
    • 2001-08-09
    • 니홍 케미칼 리써치 가부시키가이샤세이노 스스무
    • 세이노스스무야노히데끼왕창쳉
    • C07K14/62
    • C07K14/705
    • PURPOSE: Provided are human and mouse Na-driven Cl/HCO3 exchanger (sodium ion-driven chloride /bicarbonate exchanger) proteins, which are a class of proteins involved in intracellular pH regulation, and a method for selecting agonists/antagonists of the sodium ion-driven chloride/bicarbonate exchanger proteins. CONSTITUTION: DNAs comprise nucleotide sequences of SEQ ID NO:1 or NO:3 encoding Na(+)-driven Cl(-)/HCO3- exchanger. Proteins comprise amino acid sequences of SEQ ID NO:2 or NO:4, and their homologous proteins comprise an amino acid sequence having deletion, substitution, addition or insertion amino acids, which proteins, when expressed in a cell, function as Na(+)-driven Cl(-)/HCO3- exchanger, and cells in which the proteins exogenously expressed.
    • 目的:提供人和小鼠Na驱动的Cl / HCO3交换剂(钠离子驱动的氯化物/碳酸氢盐交换剂)蛋白,其是参与细胞内pH调节的一类蛋白质,以及选择钠离子的激动剂/拮抗剂的方法 氯仿/碳酸氢盐交换蛋白。 构成:DNA包含编码Na(+) - 驱动的Cl( - )/ HCO 3 - 交换剂的SEQ ID NO:1或NO:3的核苷酸序列。 蛋白质包含SEQ ID NO:2或NO:4的氨基酸序列,并且它们的同源蛋白质包含具有缺失,取代,添加或插入氨基酸的氨基酸序列,当在细胞中表达时,该蛋白质以Na(+ ) - Cl( - )/ HCO 3 - 交换剂,以及蛋白质外源表达的细胞。