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    • 4. 发明授权
    • 한국산겨우살이로부터분리된LECTIN성분을함유하는면역증강용의약조성물
    • 药用制剂,包括从韩国MISTLETOE分离的活性成分LECTIN
    • KR100259231B1
    • 2000-07-01
    • KR1019970055486
    • 1997-10-28
    • 김종배
    • 김종배송성규곽진환윤택준강태봉박춘호서병선이관희도명술유영춘
    • A61K36/185A61P37/00
    • PURPOSE: An immunopotentiating pharmaceutical composition containing lectin ingredient such as KML-IIU and KML-IIL separated from Viscum album, Coloratum is provided, which enhances cyto-reactivity for immunopotentiating, and amplifying number of cells for antigen-specific immune reaction. CONSTITUTION: A process for the preparation of immunopotentiating pharmaceutical composition containing lectin ingredient separated from Viscum album, Coloratum comprises the steps of: preparing Viscum album, Coloratum during December and February, washing for 3times, chopping, extracting with 0.15MNaCl solution for 8-12hrs at 4deg.C, and centrifuging to get upper layer; precipitating protein with ammonium sulfate powder, and centrifuging again, resuspending in PBS, dialyzing, filtering, washing with PBS to get KML-C; dialyzing KML-C with PBS to remove galactose, and passing through immuno affinity column to separate into PBS-dissolved out part(KML-IIL) and glycine-HCL buffer-dissolved out part(KML-IIU).
    • 目的:提供含有凝血素成分如KML-IIU和KML-IIL的免疫增强药物组合物,其从Viscum相册Coloratum分离,其增强免疫增强的细胞反应性,并扩增抗原特异性免疫反应的细胞数。 构成:制备含有从Viscum专辑Coloratum分离的凝集素成分的免疫增强药物组合物的方法包括以下步骤:在12月和2月制备Viscum专辑,Coloratum洗涤3次,切碎,用0.15MNaCl溶液萃取8-12小时 在4℃下离心分离得到上层; 用硫酸铵粉末沉淀蛋白,再次离心,重悬于PBS中,透析,过滤,用PBS洗涤得到KML-C; 用PBS透析KML-C以除去半乳糖,并通过免疫亲和柱分离成PBS溶解的部分(KML-IIL)和甘氨酸-HCl缓冲溶解部分(KML-IIU)。
    • 7. 发明公开
    • 항종양활성 증진용 조성물
    • 用于促进抗癌活性的组合物
    • KR1020030091386A
    • 2003-12-03
    • KR1020020029326
    • 2002-05-27
    • 김종배
    • 김종배유영춘윤택준강태봉이관희송성규
    • A61K36/8968A61P35/00
    • PURPOSE: Provided is a composition for promoting anti-cancer activity by using a Viscum album Coloratum. extract or its lectin components which inhibits the proliferation and metastasis of cancer. CONSTITUTION: A composition for promoting anti-cancer activity is characterized by containing, as an active ingredient, 1ng/mL of an arsenic compound or 5-10ng/mL of an alkylating anticancer agent obtained by detoxifying 5-10 microgram/mL of a hot water extract of Viscum album Coloratum. It is also characterized by containing, as an active ingredient, 1ng/mL of an arsenic compound or 5-10ng/mL of an alkylating anticancer agent obtained by detoxifying 10-20 ng/mL of a lectin containing component from the extract of Viscum album Coloratum.
    • 目的:提供使用Viscum专辑Coloratum来促进抗癌活性的组合物。 提取物或其凝集素组分,其抑制癌症的增殖和转移。 构成:用于促进抗癌活性的组合物的特征在于,含有1ng / mL的砷化合物或5-10ng / mL的通过使5-10微克/ mL的热消毒而得到的烷基化抗癌剂 Viscum专辑Coloratum的水提取物。 其特征在于,含有1ng / mL砷化合物或5-10ng / mL通过从Viscum专利提取物中除去10-20ng / mL含凝集素的组分得到的烷基化抗癌剂 Coloratum。