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1. 发明授权

KR101299928B1 내파열성 서방형 투여 형태 有权
标题翻译：抗断裂延迟释放形式的给药
公开(公告)号：KR101299928B1
公开(公告)日：2013-08-27
申请号：KR1020077020241
申请日：2006-02-06
申请人： 그뤼넨탈 게엠베하
发明人： 애시워쓰주디 , 아르케나우-마릭엘리자베스 , 바르톨로마우스요하네스 , 쿠겔만하인리히
IPC分类号： A61K9/22 , A61K9/52 , A61K47/30
CPC分类号： A61K31/485 , A61J3/005 , A61J3/06 , A61J3/10 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2031 , A61K9/205 , A61K9/2054 , A61K9/2068 , A61K9/2072 , A61K9/2086 , A61K9/2095 , A61K9/2893 , A61K9/4808 , A61K31/135 , A61K31/277 , A61K31/4418 , A61K31/4422 , A61K31/55 , A61K31/554 , B29B7/002 , B29B9/02 , B29B9/12 , B29C35/0261 , B29C43/02 , B29C45/0001 , B29C47/0004 , B29C47/004 , B29C47/0066 , B29C47/0085 , B29C47/065 , B29C2793/009 , B29K2105/0035 , B29K2105/0044 , B29K2105/251 , B29K2995/0056 , B29L2031/753 , B29L2031/772
摘要： 본 발명은 생리학적 활성 물질(A), 임의의 하나 또는 몇몇 생리학적 혼화성 부형제(B), 합성 또는 천연 중합체(C) 및 임의의 천연, 반합성 또는 합성 왁스(D)를 포함하는 투여 형태에 관한 것이다. 당해 투여 형태는 생리학적 조건하에 적어도 부분적으로 지연된 방식으로 생리학적 유효량 물질(A)을 방출하면서 최소 400N의 내파열성을 갖도록 제공된다.
서방형 투여 형태, 내파열성, 생리학적 혼화성 부형제

2. 发明公开

KR1020080059212A 3-(2-디메틸아미노메틸 사이클로헥실) 페놀 지연 제형 无效
标题翻译： 3-（2-二甲基氨基甲酰基环己基）酚残基配方
公开(公告)号：KR1020080059212A
公开(公告)日：2008-06-26
申请号：KR1020087009033
申请日：2006-09-15
申请人： 그뤼넨탈 게엠베하
发明人： 융토비아스 , 바르톨로마우스요하네스
IPC分类号： A61K9/22 , A61K31/133
CPC分类号： A61K9/286 , A61K9/2018 , A61K9/2054 , A61K31/133 , A61K47/38 , A61K2300/00
摘要： The invention relates to a form of administration for the controlled releasing of the active substance 3-(2-dimethylaminomethyl cyclohexyl) phenol, preferably (1R,2R)-3-(2-dimethylaminomethyl cyclohexyl) phenol, or one of the pharmaceutically acceptable salts thereof. Said form of administration (i) in vivo reaches the peak plasma level of the active substance after 2 to 10 h, and/or (ii) in vitro releases 3.0 to 37 percent by weight of the active substance originally contained therein after 05 hours, 5.0 to 56 percent by weight after 1 hour, 10 to 77 percent by weight after 2 hours, 15 to 88 percent by weight after 3 hours, at least 30 percent by weight after 6 hours, at least 50 percent by weight after 12 hours, at least 70 percent by weight after 18 hours, and at least 80 percent by weight after 24 hours when measured according to the European pharmacopoeia by means of a blade mixer in buffer solution at a pH value of 6.9 (preferably 900 ml), a temperature of 37 °C, and 75 U/min.
摘要翻译：本发明涉及活性物质3-（2-二甲基氨基甲基环己基）苯酚，优选（1R，2R）-3-（2-二甲基氨基甲基环己基）苯酚或其药学上可接受的盐之一的受控释放的给药形式它们。所述给药形式（i）体内在2至10小时后达到活性物质的峰值血浆水平，和/或（ii）体外释放05至05之后最初含有的活性物质的3.0至37重量％ 1小时后为5.0〜56重量％，2小时后为10〜77重量％，3小时后为15〜88重量％，6小时后为至少30重量％，12小时后为至少50重量％ 18小时后至少70重量％，24小时后至少80重量％，根据欧洲药典，通过桨式混合器在pH值为6.9（优选900毫升）的缓冲溶液中测量，至少80重量％，温度 37°C和75 U / min。

3. 发明公开

KR1020070111510A 내파열성 서방형 투여 형태 有权
标题翻译：禁止延迟发布的管理形式
公开(公告)号：KR1020070111510A
公开(公告)日：2007-11-21
申请号：KR1020077020241
申请日：2006-02-06
申请人： 그뤼넨탈 게엠베하
发明人： 애시워쓰주디 , 아르케나우-마릭엘리자베스 , 바르톨로마우스요하네스 , 쿠겔만하인리히
IPC分类号： A61K9/22 , A61K9/52 , A61K47/30
CPC分类号： A61K31/485 , A61J3/005 , A61J3/06 , A61J3/10 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2031 , A61K9/205 , A61K9/2054 , A61K9/2068 , A61K9/2072 , A61K9/2086 , A61K9/2095 , A61K9/2893 , A61K9/4808 , A61K31/135 , A61K31/277 , A61K31/4418 , A61K31/4422 , A61K31/55 , A61K31/554 , B29B7/002 , B29B9/02 , B29B9/12 , B29C35/0261 , B29C43/02 , B29C45/0001 , B29C47/0004 , B29C47/004 , B29C47/0066 , B29C47/0085 , B29C47/065 , B29C2793/009 , B29K2105/0035 , B29K2105/0044 , B29K2105/251 , B29K2995/0056 , B29L2031/753 , B29L2031/772
摘要： The invention relates to a form of administration comprising a physiologically effective substance (A); one or several optional physiologically acceptable adjuvants (B); a synthetic or natural polymer (C); and an optional natural, semisynthetic, or synthetic wax (D). Said form of administration is provided with a minimum breaking strength of 400 N while releasing the physiologically effective substance (A) at least partly in a delayed manner in physiological conditions.
摘要翻译：本发明涉及包含生理有效物质（A）的给药形式; 一种或几种任选的生理上可接受的佐剂（B）; 合成或天然聚合物（C）; 和可选的天然，半合成或合成蜡（D）。所述给药形式具有400N的最小断裂强度，同时在生理条件下以延迟的方式至少部分释放生理有效物质（A）。

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