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    • 3. 发明公开
    • 리포칼린 2 수준을 측정하는 것을 포함하는 경도 인지 장애 진단용 조성물, 키트 및 경도인지 장애 진단을 위한 정보 제공방법.
    • MCI诊断组合物,测量药物LIPOCALIN 2和提供诊断信息MCI的方法
    • KR1020120119669A
    • 2012-10-31
    • KR1020110037775
    • 2011-04-22
    • 경북대학교 산학협력단
    • 석경호이호원최지혜
    • G01N33/68G01N33/53C12Q1/68
    • G01N33/6896C12Q1/6883C12Q2600/158G01N33/5302
    • PURPOSE: A composition for diagnosing disability of hardness recognition, a kit and an information providing method for diagnosing disabilities of hardness recognition are provided to distinguish patients having diagnosing disabilities of hardness recognition. CONSTITUTION: A composition for diagnosing disability of hardness recognition includes a formulation which measures mRNA or protein levels of a lipocalin 2 gene. The formulation measuring the protein level uses a specific antibody for the lipocalin 2. A formulation which measures the mRNA level is primer pair or probe which is specific for the lipocalin 2 gene. A kit for diagnosing disabilities of hardness recognition includes the composition for diagnosing the disabilities of hardness recognition. The diagnostic kit is for distinguishing the Alzheimer patient from the disability of hardness recognition. The information providing method for diagnosing disability of hardness recognition includes the following steps: measuring the level of the lipocalin 2 protein among humoral samples; and checking the increase of the lipocalin 2 proteins by comparing with a normal control group.
    • 目的:提供用于诊断硬度识别残疾的组合物,用于诊断硬度识别残疾的试剂盒和信息提供方法,以区分具有硬度识别诊断残疾的患者。 构成:用于诊断硬度识别残疾的组合物包括测量脂质运载蛋白2基因的mRNA或蛋白质水平的制剂。 测量蛋白质水平的制剂使用脂质运载蛋白2的特异性抗体。测量mRNA水平的制剂是对于脂质运载蛋白2基因特异的引物对或探针。 用于诊断硬度识别残疾的试剂盒包括用于诊断硬度识别残疾的组合物。 诊断试剂盒用于区分阿尔茨海默病患者与硬度识别的残疾。 用于诊断硬度识别残疾的信息提供方法包括以下步骤:测定体液样品中脂笼蛋白2蛋白的水平; 并通过与正常对照组比较检查脂笼蛋白2蛋白的增加。
    • 6. 发明公开
    • 행동측정판 및 이를 이용한 행동분석장치
    • 行为测量板和行为分析设备使用相同
    • KR1020120067583A
    • 2012-06-26
    • KR1020100129065
    • 2010-12-16
    • 경북대학교 산학협력단
    • 이만기장일성이호원최평정지영
    • A61B5/103A61B5/11
    • PURPOSE: A behavior measurement plate and a behavior analysis apparatus using same are provided to improve the performance of the behavioral analysis apparatus. CONSTITUTION: An action measurement board(10) is composed of a substrate(100), a fixed member(110), a vibration sensor(150), and an output unit(155). The fixed member is arranged in one side of the substrate. The fixed member is installed in the lower part of the cage accepting animals. The fixed member is made of a material having elastic force transferring the vibration due to the movement of the animals to the vibration sensor. The vibration sensor is arranged between a plurality of fixed members and substrate.
    • 目的:提供行为测量板和使用它的行为分析装置,以改善行为分析装置的性能。 构成:动作测量板(10)由基板(100),固定部件(110),振动传感器(150)和输出单元(155)构成。 固定部件设置在基板的一侧。 固定构件安装在笼子的下部接受动物。 固定构件由具有弹性力的材料制成,该材料由于动物向振动传感器的移动而传递振动。 振动传感器配置在多个固定部件和基板之间。
    • 7. 发明公开
    • 퇴행성신경질환 진단용 마커
    • 用于诊断神经源性疾病的生物标志物
    • KR1020100101465A
    • 2010-09-17
    • KR1020090019968
    • 2009-03-09
    • 경북대학교 산학협력단
    • 석경호조제열이호원
    • C12Q1/68G01N33/68G01N33/53
    • C12Q1/6804C12Q1/6876G01N33/53G01N33/6803G01N33/6896G01N2800/2814
    • PURPOSE: A biomarker for diagnosing neurodegenerative disease and a method for diagnosing neurodegenerative disease using the same are provided to measure mRNA or protein expression level. CONSTITUTION: A composition for diagnosing neurodegenerative disease contains an agent for measuring mRNA or protein level of NCAM-120(120kDa isoform precursor of neural cell adhesion molecule 1) alpha-dystroglycan or NPR(neuronal pentraxin receptor). The agent for measuring mRNA level is a primer pair or probe which is specific to NCAM-120, α-distroglycan or NPR gene. The diagnosis for neurodegenerative disease is performed by measuring mRNA level of gene in biological sample using the primer pair or probe.
    • 目的:提供用于诊断神经变性疾病的生物标志物和用于诊断神经变性疾病的方法,以测量mRNA或蛋白质表达水平。 构成:用于诊断神经变性疾病的组合物含有用于测量NCAM-120(神经细胞粘附分子1的120kDa同种型前体)α-肌浆蛋白聚糖或NPR(神经元五聚体受体)的mRNA或蛋白质水平的试剂。 用于测量mRNA水平的试剂是对NCAM-120,α-分歧聚糖或NPR基因特异性的引物对或探针。 通过使用引物对或探针测量生物样品中的基因的mRNA水平来进行神经变性疾病的诊断。
    • 8. 发明公开
    • 가용성 CD14의 파킨슨 병 진단 및 치료용 용도
    • 使用可溶性CD14进行诊断和治疗神经损伤性疾病
    • KR1020100101467A
    • 2010-09-17
    • KR1020090019971
    • 2009-03-09
    • 경북대학교 산학협력단
    • 석경호조제열이호원
    • C12Q1/68G01N33/53
    • C12Q1/6876G01N33/53G01N33/6896G01N2800/2835
    • PURPOSE: A soluble CD14 which is overexpressed in neurodegenerative diseases is provided to diagnose and treat neurodegenerative diseases. CONSTITUTION: A composition for diagnosing neurodegenerative diseases contains an agent for measuring soluble CD14 mRNA or protein. Neurodegenerative diseases are Alzheimer's disease, Parkinson's disease, Lou Gehrig's disease, Huntington's disease, or senile dementia. The agent for measuring mRNA level is a primer pair or probe which is specific to CD14 gene. The agent for measuring protein is an antibody which is specific to CD14 gene. The diagnosis for neurodegenerative diseases is performed by measuring protein level of a gene in a biological sample using the specific antibody. The biological sample is cerebrospinal fluid. A pharmaceutical composition for treating neurodegenerative diseases contains soluble CD14.
    • 目的:提供神经变性疾病中过表达的可溶性CD14来诊断和治疗神经变性疾病。 构成:用于诊断神经变性疾病的组合物含有用于测量可溶性CD14mRNA或蛋白质的试剂。 神经变性疾病是阿尔茨海默氏病,帕金森氏症,Lou Gehrig病,亨廷顿氏病或老年痴呆症。 用于测量mRNA水平的试剂是对CD14基因特异性的引物对或探针。 用于测定蛋白质的试剂是对CD14基因特异性的抗体。 通过使用特异性抗体测量生物样品中的基因的蛋白质水平来进行神经变性疾病的诊断。 生物样品是脑脊液。 用于治疗神经变性疾病的药物组合物含有可溶性CD14。