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2. 发明公开

KR1020040069957A 메실산 나파모스타트의 결정 다형 및 그 제조방법 失效
标题翻译： NAFAMOSTAT MESILATE作为药物及其生产方法的晶体多态性
公开(公告)号：KR1020040069957A
公开(公告)日：2004-08-06
申请号：KR1020030092850
申请日：2003-12-18
申请人： 가부시키가이샤 시즈오까 카페인 고교쇼
发明人： 나까또가와기요시 , 야기히로시 , 이도다까히로
IPC分类号： C07C279/18
摘要： PURPOSE: Provided are a crystal polymorphism of nafamostat mesilate useful as drugs and a method for producing the same. CONSTITUTION: The crystal polymorphism of nafamostat mesilate is characterized in that it shows strong diffraction peaks at 17.0, 18.4, 19.3, 19.9, 20.9, 24.3, and 26.3 degrees at a diffraction angle (2θ±0.1 degree) in the powder X-ray diffraction pattern. The method for producing crystal polymorphism of nafamostat mesilate comprises the process of performing phase inversion of nafamostat mesilate showing strong diffraction peaks or specific peaks at 9.0, 13.0, 17.1, 18.1, 19.3, 19.8, 20.2, 21.4, 22.4, 23.4 and 23.7 degrees at a diffraction angle (2θ±0.1 degree) in the powder X-ray diffraction pattern in the state that the nafamostat mesilate is suspended in alcohol.
摘要翻译：目的：提供可用作药物的甲磺酸奈马莫司他晶体多晶型及其制备方法。构成：甲磺酸奈马莫司托的晶体多晶型物的特征在于，在粉末X射线衍射角度（2θ±0.1度）处，其在17.0,18.4,19.3,19.9,20.9,24.3和26.3度处显示出强衍射峰衍射图案。奈非莫斯特甲磺酸盐的晶体多晶型的制备方法包括在9.0,13.0,17.1,18.1,19.3,19.8,20.2,21.4,22.4,23.4和23.7度处显示出强衍射峰或特定峰的奈非莫斯特甲磺酸盐的相转化过程粉末X射线衍射图中的衍生角（2＆thgr;±0.1度），其在甲胺盐酸盐中的悬浮状态。

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