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1. 发明公开

KR1020030066136A 홍삼 또는 인삼정분을 함유하는 구형의 미세캡슐 제조방법 有权
标题翻译：制备含有红葡萄酒或金松提取物粉末的球形微球的方法
公开(公告)号：KR1020030066136A
公开(公告)日：2003-08-09
申请号：KR1020020006318
申请日：2002-02-04
申请人： (주)케비젠 , 주식회사 일화
发明人： 김동명 , 박세호 , 신홍식 , 박시호
IPC分类号： A61K9/58
CPC分类号： A23P10/30 , A23L19/00 , A23L33/10 , A23V2002/00 , A23V2250/2124
摘要： PURPOSE: Provided is a method for preparing the spherical microcapsule of the red ginseng or ginseng extract powders which is stable to the chemical reaction and non-irritative, and conceals the bitter taste of the red ginseng or ginseng by coating the red ginseng or ginseng extract powders with at least one of water soluble polymers. CONSTITUTION: The method for preparing the spherical microcapsule of the red ginseng or ginseng extract powders comprises a step for warming the solution obtained by adding sugar, water soluble starch or hydrophilic polymer to the purified water and then drying it to form the particulate solid state core seeds; a step for coating the core seeds with the red ginseng or ginseng extract powders to form the particulate of 500 to 800 micrometers, thereby preparing the rapid release type spherical microcapsule; a step for coating the rapid release type spherical microcapsule with the polymer coating solution in an amount of 20 to 40 % by total weight of coating film composition of a delayed release type spherical microcapsule to form the delayed release type spherical microcapsule of 1000 to 1200 micrometers; a step for hardening and drying the coating film of the delayed release type spherical microcapsule to a moisture content of 1 to 10 % by total weight of the coating film capsule composition; and a step for meshing the dried microcapsule to 1000 to 1200 micrometers.
摘要翻译：目的：提供红参人参或人参提取物粉末的球形微胶囊的制备方法，其对化学反应和非刺激性均稳定，并通过将红参或人参提取物包衣而掩盖红参或人参的苦味具有至少一种水溶性聚合物的粉末。构成：红参或人参提取物粉末的球形微胶囊的制备方法包括将通过将糖，水溶性淀粉或亲水性聚合物加入到纯化水中得到的溶液进行加温，然后干燥形成颗粒状固体核的步骤种子; 用红参人参或人参提取物粉末涂覆核心种子以形成500至800微米的颗粒的步骤，从而制备快速释放型球形微胶囊; 用快速释放型球形微胶囊涂覆快速释放型球形微胶囊的步骤，其中聚合物涂布溶液的用量为延迟释放型球形微胶囊的涂膜组合物总重量的20-40％，以形成1000至1200微米的延迟释放型球形微胶囊 ; 将延迟释放型球形微胶囊的涂膜硬化并干燥至涂膜胶囊组合物的总重量为1〜10％的水分的工序; 以及将干燥的微胶囊啮合到1000至1200微米的步骤。

2. 发明授权

KR100466719B1 홍삼 또는 인삼정분을 함유하는 구형의 미세캡슐 제조방법 有权
标题翻译： 홍삼또는인삼정분을함유하하는구형의미세캡슐제조방홍삼
公开(公告)号：KR100466719B1
公开(公告)日：2005-01-17
申请号：KR1020020006318
申请日：2002-02-04
申请人： (주)케비젠 , 주식회사 일화
发明人： 김동명 , 박세호 , 신홍식 , 박시호
IPC分类号： A61K9/58
摘要： PURPOSE: Provided is a method for preparing the spherical microcapsule of the red ginseng or ginseng extract powders which is stable to the chemical reaction and non-irritative, and conceals the bitter taste of the red ginseng or ginseng by coating the red ginseng or ginseng extract powders with at least one of water soluble polymers. CONSTITUTION: The method for preparing the spherical microcapsule of the red ginseng or ginseng extract powders comprises a step for warming the solution obtained by adding sugar, water soluble starch or hydrophilic polymer to the purified water and then drying it to form the particulate solid state core seeds; a step for coating the core seeds with the red ginseng or ginseng extract powders to form the particulate of 500 to 800 micrometers, thereby preparing the rapid release type spherical microcapsule; a step for coating the rapid release type spherical microcapsule with the polymer coating solution in an amount of 20 to 40 % by total weight of coating film composition of a delayed release type spherical microcapsule to form the delayed release type spherical microcapsule of 1000 to 1200 micrometers; a step for hardening and drying the coating film of the delayed release type spherical microcapsule to a moisture content of 1 to 10 % by total weight of the coating film capsule composition; and a step for meshing the dried microcapsule to 1000 to 1200 micrometers.
摘要翻译：目的：提供一种制备红参或人参提取物粉末的球形微胶囊的方法，该球形微胶囊对化学反应和非刺激性是稳定的，并通过涂覆红参或人参提取物来掩盖红参或人参的苦味粉末与至少一种水溶性聚合物。构成：制备红参或人参提取物粉末的球形微胶囊的方法包括将通过加入糖，水溶性淀粉或亲水性聚合物得到的溶液加热到纯化水中，然后干燥以形成颗粒状固体核的步骤种子; 用红参或人参提取物粉末包覆核心种子以形成500-800微米的颗粒，由此制备快速释放型球形微囊; 以延迟释放型球状微胶囊的涂膜组合物的总重量为20至40％的量涂覆快速释放型球状微胶囊以形成1000至1200微米的缓释型球状微胶囊的步骤 ; 将所述延迟释放型球形微胶囊的涂膜硬化并干燥至所述涂膜胶囊组合物的总重量的1至10％的水分含量的步骤; 以及将干燥的微胶囊啮合至1000至1200微米的步骤。

3. 发明授权

KR100508627B1 신규한 레티노이드 유도체 및 이의 제조방법 및 그화합물을 함유한 항암제 조성물 有权
标题翻译：新型类视黄醇衍生物和用于制备所述化合物的方法和包含所述化合物的抗癌药物组合物
公开(公告)号：KR100508627B1
公开(公告)日：2005-08-17
申请号：KR1020020015016
申请日：2002-03-20
申请人： (주)케비젠
发明人： 신홍식 , 엄수종 , 노영쇠 , 박시호 , 권윤자 , 박명순 , 한혜숙 , 김소미 , 김동명 , 오덕근 , 박종섭 , 배태성
IPC分类号： C07C235/78
摘要： 본 발명은 화학식1로 표시되는 신규한 레티노이드 유도체 화합물 또는 이의 약제학적으로 허용되는 염에 관한 것이다:
화학식 1

상기식에서, X, R
1 , R
2 및 R
3 은 본원에 정의한 바와 같다. 또한, 본 발명은 상기 레티노이드 유도체 화합물의 제조 방법 및 그러한 화합물을 함유하는 항암제 조성물에 관한 것이다. 본 발명에 따른 화학식1의 화합물은 고도의 항암 활성을 나타내면서 유해한 부작용을 유발하지 않는다.

4. 发明公开

KR1020030063019A 고도불포화지방산을 함유하는 유화조성물 및 그의미세액정캡슐 제조방법 无效
标题翻译：含有高度不饱和脂肪酸的乳液组合物及其液晶微生物的生产
公开(公告)号：KR1020030063019A
公开(公告)日：2003-07-28
申请号：KR1020020003552
申请日：2002-01-22
申请人： (주)케비젠 , 주식회사 일신웰스
发明人： 김동명 , 한기왕
IPC分类号： A61K9/10
CPC分类号： B01F17/0092 , A23L2/52 , A23P10/35 , A61K8/068 , A61K8/11 , A61K9/1075 , A61K2800/21 , A61K2800/412 , A61K2800/56 , A61Q19/00
摘要： PURPOSE: A method of preparing liquid-crystal microcapsules of 10 microns or less for improving the stabilization and functionality of an unstable functional material using an emulsion composition is provided. Therefore, the microcapsules can be effectively used for encapsulation of high concentration of physiologically active substances that are unstable and are useful for various formulations of foods, medicines, commodities or the like. CONSTITUTION: An oil phase containing 48 to 67% by weight of an oil base, 2 to 10% by weight of one or more liquid-crystal film forming agents and 10 to 15% by weight of a surfactant is agitated with a water phase containing 10 to 15% by weight of an aqueous polymer material and purified water at 55 to 60deg.C at a speed of 2,000 to 3,000rpm, cooled to 40 to 45 deg.C, agitated with 1 to 5% by weight of a thickener and 1 to 25% by weight of an additive at a speed of 20 to 30rpm and then cooled to 20 to 25deg.C. The oil phase is prepared by emulsion-coating the oil base containing highly unsaturated fatty acid with an emulsifier in the presence of N2 gas three times.
摘要翻译：目的：提供一种制备10微米或更小的液晶微胶囊以提高使用乳液组合物的不稳定功能材料的稳定性和官能度的方法。因此，微胶囊可以有效地用于高浓度的不稳定的生理活性物质的包封，并且可用于食品，药品，商品等的各种制剂。构成：将含有48〜67重量％油基，2〜10重量％的一种或多种液晶成膜剂和10〜15重量％表面活性剂的油相用含有 10至15重量％的聚合物水性材料和纯水在55至60℃下以2000至3,000rpm的速度冷却至40至45℃，用1至5重量％的增稠剂搅拌， 1至25重量％的添加剂，速度为20至30rpm，然后冷却至20至25℃。油相通过在N 2气存在下用乳化剂将含有高度不饱和脂肪酸的油基油乳液涂覆三次来制备。

5. 发明公开

KR1020030062126A 효소 활성이 증가된 인간 베타, 베타 - 카로틴 15, 15' -디옥시게나제의 유전자 변이체 无效
标题翻译：人类BETA，具有改善酶活性的十五碳十二烷酸的突变体基因
公开(公告)号：KR1020030062126A
公开(公告)日：2003-07-23
申请号：KR1020020002561
申请日：2002-01-16
申请人： (주)케비젠
发明人： 엄수종 , 장판식 , 김소미 , 박찬수 , 한혜숙 , 신원필 , 신홍식 , 박시호 , 김동명
IPC分类号： C12N15/53
CPC分类号： C12N9/0069 , C12P7/02 , C12Y113/11063
摘要： PURPOSE: Mutant genes of human beta, beta-carotene 15, 15'-dioxygenase having improved enzyme activity are provided, so that enzyme proteins expressed from the mutant genes can be used in various fields related to the vitamin A production. CONSTITUTION: Mutant genes of human beta, beta-carotene 15, 15'-dioxygenase are produced by error-prone PCR using a human beta, beta-carotene 15, 15'-dioxygenase gene as templates, and have the enzyme activity of the expressed protein of 1100 pmol/h. A method for producing vitamin A comprises digesting beta-carotene using the expressed human beta, beta-carotene 15, 15'-dioxygenase. A method for producing vitamin A comprises transforming a host cell using the mutant genes of human beta, beta-carotene 15, 15'-dioxygenase, and culturing the transformed host cell in a medium, wherein the host cell is a plant cell, a prokaryotic cell, a yeast cell, an insect cell, a mammal cell or a poultry cell.
摘要翻译：目的：提供具有改善的酶活性的人β，β-胡萝卜素15,15'-双加氧酶的突变基因，使得从突变基因表达的酶蛋白可用于与维生素A生产相关的各种领域。构成：使用人β，β-胡萝卜素15,15'-双加氧酶基因作为模板，通过易错PCR产生人β，β-胡萝卜素15,15'-双加氧酶的突变基因，并具有表达的酶活性蛋白质为1100 pmol / h。生产维生素A的方法包括使用表达的人β，β-胡萝卜素15,15'-双加氧酶消化β-胡萝卜素。生产维生素A的方法包括使用人β，β-胡萝卜素15,15'-双加氧酶的突变基因转化宿主细胞，并在培养基中培养转化的宿主细胞，其中宿主细胞是植物细胞，原核细胞，酵母细胞，昆虫细胞，哺乳动物细胞或家禽细胞。

6. 发明公开

KR1020020090850A 신규한 레티노이드 유도체 및 이의 제조방법 및 그화합물을 함유한 항암제 조성물 有权
标题翻译：含有衍生物的新型复方衍生物，制剂方法和抗癌药物组合物
公开(公告)号：KR1020020090850A
公开(公告)日：2002-12-05
申请号：KR1020020015016
申请日：2002-03-20
申请人： (주)케비젠
发明人： 신홍식 , 엄수종 , 노영쇠 , 박시호 , 권윤자 , 박명순 , 한혜숙 , 김소미 , 김동명 , 오덕근 , 박종섭 , 배태성
IPC分类号： C07C235/78
摘要： PURPOSE: A novel retinoid derivative, its preparation method, a compound used for preparing the derivative, and an anticancer medicine composition containing the derivative are provided, which retinoid derivative shows the excellent anticancer activity and no toxic side effect. CONSTITUTION: The retinoid derivative is represented by the formula I, wherein R¬1 and R¬2 are independent each other and are OH, SH, NH2, COOH, -R(CH2)mCH3, -RCOCO(CH2)mCH3, -RCO(CH2)mCHCH3CH3, or -RCOCH(NCOCH3)CH2CH2CONH2, and R¬3 is H; R¬1 and R¬3 are independent each other and are OH, SH, NH2, COOH, -R(CH2)mCH3, -RCOCO(CH2)mCH3, or -RCOCH(NCOCH3)CH2CH2CONH2, and R¬2 is H; R¬1 is OH, SH, NH2, COOH, -R(CH2)mCH3, R¬2 is H, and R¬3 is H, OH or Cl; R¬3 is OH, SH, NH2, COOH, -R(CH2)mCH3, or -RCOCH(NCOCH3)CH2CH2CONH2, R¬2 is H, and R¬1 is H, OH or Cl; or R¬1, R¬2 and R¬3 are independent each another and are OH, SH, NH2, COOH, -R(CH2)mCH3, or -RCOCH(NCOCH3)CH2CH2CONH2; and R is CH2, O, NH or S, R¬4 is H or an alkyl group of C1-C6, and m is an integer of 0-5.
摘要翻译：目的：提供一种新型类视黄醇衍生物及其制备方法，用于制备衍生物的化合物和含有该衍生物的抗癌药物组合物，其视黄酸衍生物显示出优异的抗癌活性，无毒副作用。构型：类视黄醇衍生物由式I表示，其中R 1和R 2彼此独立，为OH，SH，NH 2，COOH，-R（CH 2）m CH 3，-RCOCO（CH 2）m CH 3，-RCO （CH 2）m CHCH 3 CH 3或-RCOCH（NCOCH 3）CH 2 CH 2 CONH 2，R 3 3是H; R 1和R 3彼此独立地是OH，SH，NH 2，COOH，-R（CH 2）mCH 3，-OCOO（CH 2）mCH 3或-RCOCH（NCOCH 3）CH 2 CH 2 CONH 2，R 12是H; R 1是OH，SH，NH 2，COOH，-R（CH 2）mCH 3，R 2是H，R 3是H，OH或Cl; R 3是OH，SH，NH 2，COOH，-R（CH 2）m CH 3或-RCOCH（NCOCH 3）CH 2 CH 2 CONH 2，R 2是H，R 1是H，OH或Cl; 或R 1，R 2和R 3彼此独立，并且是OH，SH，NH 2，COOH，-R（CH 2）mCH 3或-RCOCH（NCOCH 3）CH 2 CH 2 CONH 2; 且R为CH 2，O，NH或S，R 4为H或C 1 -C 6烷基，m为0-5的整数。

7. 发明授权

KR100464061B1 아라비노스 이성화효소의 고정화에 의한 타가토스의 생산방법 有权
标题翻译： 아라비노스이성화효소의고정화에의한타가토스의생산방
公开(公告)号：KR100464061B1
公开(公告)日：2004-12-30
申请号：KR1020020026615
申请日：2002-05-15
申请人： (주)케비젠
发明人： 오덕근 , 김소미 , 신홍식 , 엄수종 , 노영쇠 , 박종섭 , 김동명 , 박시호
IPC分类号： C12P19/02
摘要： PURPOSE: A method for producing tagatose by immobilization of arabinose isomerase is provided. Tagatose is cheaply and effectively mass-produced by maintaining the enzyme activity for a long time. CONSTITUTION: A method for producing tagatose by immobilization of arabinose isomerase comprises binding arabinose isomerase to resin, bridging arabinose isomerase with glutaraldehyde to immobilize the arabinose isomerase, and reacting the immobilized arabinose isomerase with substrate, wherein the concentration of arabinose isomerase is 10 mg/ml; the resin is sodium alginate, alumina or silica; the sodium alginate is used by dissolving 1.5 to 4.0% of sodium alginate in water; the alumina is used by dissolving 60 to 70% of alumina in 50 mM tris buffer solution; the silica is used by dissolving 60 to 70% of silica in 50 mM tris buffer solution; substrate is galactose; the galactose is used by dissolving 45 to 55% of galactose in pH 7 to 8 tris buffer solution; and the reaction temperature is 55 to 65 deg. C.
摘要翻译：目的：提供一种通过固定阿拉伯糖异构酶来生产塔格糖的方法。塔格糖通过长期维持酶活性而廉价且有效地大量生产。构成：通过固定阿拉伯糖异构酶生产塔格糖的方法包括将阿拉伯糖异构酶与树脂结合，将阿拉伯糖异构酶与戊二醛桥接以固定阿拉伯糖异构酶，并使固定的阿拉伯糖异构酶与底物反应，其中阿拉伯糖异构酶的浓度为10mg / ml ; 该树脂是海藻酸钠，氧化铝或二氧化硅; 海藻酸钠通过在水中溶解1.5至4.0％的海藻酸钠来使用; 通过在50mM tris缓冲溶液中溶解60-70％的氧化铝来使用氧化铝; 二氧化硅是通过将60-70％的二氧化硅溶解在50mM tris缓冲溶液中而使用的; 底物是半乳糖; 半乳糖通过在pH 7至8 Tris缓冲溶液中溶解45-55％半乳糖来使用; 反应温度为55〜65℃。 C。

8. 发明授权

KR100437102B1 신규한 레티놀 유도체, 그 제조방법 및 그 용도 有权
标题翻译： 신규한레티놀유도체，그제조방법및그용도
公开(公告)号：KR100437102B1
公开(公告)日：2004-06-23
申请号：KR1020020001178
申请日：2002-01-09
申请人： (주)케비젠
发明人： 신홍식 , 박시호 , 노영쇠 , 엄수종 , 권윤자 , 박명순 , 한혜숙 , 정민숙 , 김소미 , 김동명 , 오덕근 , 박종섭
IPC分类号： C07K5/00
摘要： PURPOSE: Provided are a novel retinol derivative, its preparation method in higher yield, and its use. The novel retinol has excellent light-stability, and shows high reactivity to retinoic acid receptor α, while showing low reactivity to retinoic receptor β and γ. It can applied to medical products, cosmetics, soap, shampoo, functional foods, etc., for the prevention and improvement of skin aging. CONSTITUTION: The novel retinol derivative is characterized by carboester bond of a peptide material having COOH group, wherein the peptide material having COOH group is selected from -di, -tri, -poly peptide including N-L- α-aspartyl-L-phenylalanine 1-methylester(AMP;aspartame), N-protection group-aspartame, neotame and the like. Its manufacturing method comprises the steps of: reacting retinylacetate with methanolic solvent and inorganic slat at 25-40 deg.C in a dark room then extracting the reaction product with ether solvent; removing the solvent then followed by mixing a compound having OH group, natural or separated and purified retinol, diethylazodicarboxylate and triphenylphosphate with methylenechloride solvent, and reacting them at room temperature to obtain the ester derivative of retinol; and performing chromatography with reverse-phase, Merck Silicagel 60 RP 18(40-63) micro meter to separate pure ester derivative of retinol.
摘要翻译：目的：提供一种新颖的视黄醇衍生物及其制备方法，其收率较高，并且其用途。该新型视黄醇具有优异的光稳定性，并且对视黄酸受体α具有高反应性，而对视黄酸受体β具有低反应性; 和＆amp; gamma ;. 它可以应用于医疗产品，化妆品，肥皂，洗发水，功能性食品等，以预防和改善皮肤老化。构成：新颖的视黄醇衍生物的特征在于具有COOH基团的肽材料的羧基酯键，其中具有COOH基团的肽材料选自包括NL-和α-天冬氨酰-L- 苯丙氨酸1-甲酯（AMP;天冬甜素），N-保护基 - 阿斯巴甜，纽甜等。其制造方法包括以下步骤：在25-40℃，在黑暗的房间内将乙酸视黄醇酯与甲醇溶剂和无机薄片反应，然后用乙醚溶剂萃取反应产物; 然后除去溶剂，然后将具有OH基团的化合物，天然或分离纯化的视黄醇，偶氮二羧酸二乙酯和磷酸三苯酯与二氯甲烷溶剂混合，并在室温下反应，得到视黄醇的酯衍生物; 并用反相色谱（Merck Silicagel 60 RP 18（40-63）微米）进行色谱分离以分离视黄醇的纯酯衍生物。

9. 发明公开

KR1020030088749A 아라비노스 이성화효소의 고정화에 의한 타가토스의 생산방법 有权
标题翻译：通过阿拉伯糖异构酶的固定生产标签的方法
公开(公告)号：KR1020030088749A
公开(公告)日：2003-11-20
申请号：KR1020020026615
申请日：2002-05-15
申请人： (주)케비젠
发明人： 오덕근 , 김소미 , 신홍식 , 엄수종 , 노영쇠 , 박종섭 , 김동명 , 박시호
IPC分类号： C12P19/02
摘要： PURPOSE: A method for producing tagatose by immobilization of arabinose isomerase is provided. Tagatose is cheaply and effectively mass-produced by maintaining the enzyme activity for a long time. CONSTITUTION: A method for producing tagatose by immobilization of arabinose isomerase comprises binding arabinose isomerase to resin, bridging arabinose isomerase with glutaraldehyde to immobilize the arabinose isomerase, and reacting the immobilized arabinose isomerase with substrate, wherein the concentration of arabinose isomerase is 10 mg/ml; the resin is sodium alginate, alumina or silica; the sodium alginate is used by dissolving 1.5 to 4.0% of sodium alginate in water; the alumina is used by dissolving 60 to 70% of alumina in 50 mM tris buffer solution; the silica is used by dissolving 60 to 70% of silica in 50 mM tris buffer solution; substrate is galactose; the galactose is used by dissolving 45 to 55% of galactose in pH 7 to 8 tris buffer solution; and the reaction temperature is 55 to 65 deg. C.
摘要翻译：目的：提供通过阿拉伯糖异构酶固定生产塔格糖的方法。通过长时间维持酶活性，塔提糖便宜而有效地批量生产。构成：通过阿拉伯糖异构酶的固定制备塔格糖的方法包括将阿拉伯糖异构酶与树脂结合，用戊二醛桥接阿拉伯糖异构酶以固定阿拉伯糖异构酶，并使固定的阿拉伯糖异构酶与底物反应，其中阿拉伯糖异构酶的浓度为10mg / ml ; 树脂是藻酸钠，氧化铝或二氧化硅; 通过将1.5〜4.0％的藻酸钠溶于水中使用藻酸钠; 通过将60〜70％的氧化铝溶解在50mM tris缓冲溶液中来使用氧化铝; 通过将60〜70％的二氧化硅溶解在50mM tris缓冲溶液中来使用二氧化硅; 底物是半乳糖; 通过将45至55％的半乳糖溶解在pH7至8 tris缓冲溶液中来使用半乳糖; 反应温度为55〜65℃。 C。

10. 发明公开

KR1020030075213A 항암물질을 함유하는 수용성 필름제 및 이의 제조방법 无效
标题翻译：含有防腐剂物质的水溶性膜及其生产
公开(公告)号：KR1020030075213A
公开(公告)日：2003-09-26
申请号：KR1020020014263
申请日：2002-03-16
申请人： (주)케비젠
发明人： 김동명 , 박종섭 , 김소미 , 노영쇠 , 박시호 , 신홍식 , 엄수종 , 오덕근
IPC分类号： A61K9/50
CPC分类号： A61K9/7007 , A61K9/5021
摘要： PURPOSE: A process of preparing a water-soluble film having a high solid content, a low viscosity at wide pH range and excellent dispersion stability without causing solidification is provided. Therefore, the film has excellent dispersion stability and prevents the anticancer substances from being released fast after the destruction of the resin film and is thus effectively used in controlled released drug delivery systems, skin absorbing agents, patch agents or the like. CONSTITUTION: A water-soluble film(1) is prepared by: forming a microcapsule by coating anticancer substances(3) with aminoaldehyde polycondensated resin; and then coating the microcapsule with a water-soluble polymer.
摘要翻译：目的：提供固体成分高，在宽pH范围内的低粘度，优异的分散稳定性而不引起凝固的水溶性薄膜的制造方法。因此，该膜具有优异的分散稳定性，并且防止了抗癌物质在树脂膜破坏之后快速释放，因此有效地用于受控释放的药物递送系统，皮肤吸收剂，贴剂等中。构成：通过以下方法制备水溶性薄膜（1）：通过用氨基醛缩聚树脂涂覆抗癌物质（3）形成微胶囊; 然后用水溶性聚合物涂布微胶囊。

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